1-BOC-3-PIPERIDINECARBOXALDEHYDE
- Product Name
- 1-BOC-3-PIPERIDINECARBOXALDEHYDE
- CAS No.
- 118156-93-7
- Chemical Name
- 1-BOC-3-PIPERIDINECARBOXALDEHYDE
- Synonyms
- tert-butyl 3-formylpiperidine-1-carboxylate;CAS:118156-93-7;BUTTPARK 147\06-01;1-BOC-3-PIPERIDINECA;1-BOC-3-PIPERIDINECAR;1-Boc-3-formylpiperidine;N-BOC-3-FORMYLPIPERIDINE;3-ForMyl-N-BOCpiperidine;1-N-BOC-3-FORMYLPIPERIDINE;1-Boc-3-ForMyl-piperidine 97%
- CBNumber
- CB1362192
- Molecular Formula
- C11H19NO3
- Formula Weight
- 213.27
- MOL File
- 118156-93-7.mol
1-BOC-3-PIPERIDINECARBOXALDEHYDE Property
- Boiling point:
- 295.4±33.0 °C(Predicted)
- Density
- 1.114±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- liquid
- pka
- -2.29±0.40(Predicted)
- color
- Clear, light yellow
- Sensitive
- Air Sensitive
- InChI
- InChI=1S/C11H19NO3/c1-11(2,3)15-10(14)12-6-4-5-9(7-12)8-13/h8-9H,4-7H2,1-3H3
- InChIKey
- CTVHINDANRPFIL-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCCC(C=O)C1
- CAS DataBase Reference
- 118156-93-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,N,Xn
- Risk Statements
- 36/37/38-50-36-22
- Safety Statements
- 26-36/37/39-61-37
- RIDADR
- UN3077
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B695105
- Product name
- tert-Butyl3-Formylpiperidine-1-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 069307
- Product name
- 3-Formyl-N-(tert-butoxycarbonyl)piperidine
- Purity
- >95%
- Packaging
- 5g
- Price
- $68
- Updated
- 2021/12/16
- Product number
- FB139948
- Product name
- tert-Butyl 3-formylpiperidine-1-carboxylate
- Packaging
- 2g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- JK441378
- Product name
- 1-Boc-3-piperidinecarboxaldehyde
- Purity
- 97%
- Packaging
- 250mg
- Price
- $43
- Updated
- 2021/12/16
- Product number
- FB139948
- Product name
- tert-Butyl 3-formylpiperidine-1-carboxylate
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
1-BOC-3-PIPERIDINECARBOXALDEHYDE Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid
Uses
1-Boc-piperidine-3-carboxaldehyde is used as an organic chemical synthesis intermediate.
Synthesis
116574-71-1
118156-93-7
General procedure for the synthesis of 1-Boc-3-piperidinecarboxaldehyde from tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate: a solution of dimethylsulfoxide (DMSO, 0.18 mL, 2.6 mmol) in dichloromethane (CH2Cl2, 5 mL) was slowly added dropwise at -78 °C to a solution of oxalyl chloride (2 M in CH2Cl2, 0.65 mL, 1.3 mmol ) in a solution of methylene chloride (4 mL). The reaction mixture was stirred at -68 °C for 15 min. Subsequently, tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate (0.22 g, 1.0 mmol) was added dropwise to a dichloromethane (4 mL) solution. After continued stirring at -78 °C for 15 min, triethylamine (Et3N, 6 mL) was added. The reaction mixture was warmed to room temperature and stirred for 16 hours. Upon completion of the reaction, water was added to quench the reaction and the mixture was extracted with ether. The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give the yellow oily product 1-Boc-3-piperidinecarboxaldehyde (0.20 g, 92% yield). The crude product could be directly used in the subsequent reaction without further purification. Mass spectrum (ESI) m/z 214 (M + 1).
References
[1] Patent: WO2006/62465, 2006, A1. Location in patent: Page/Page column 40
[2] Patent: US2004/229864, 2004, A1. Location in patent: Page/Page column 11
[3] Patent: US2017/313683, 2017, A1. Location in patent: Paragraph 0560-0561
[4] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 4, p. 1368 - 1373
[5] Patent: US2014/31354, 2014, A1. Location in patent: Paragraph 0421; 0422
1-BOC-3-PIPERIDINECARBOXALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
1-BOC-3-PIPERIDINECARBOXALDEHYDE Suppliers
- Tel
- --
- Fax
- --
- interchim@interchim.com
- Country
- France
- ProdList
- 6302
- Advantage
- 76
View Lastest Price from 1-BOC-3-PIPERIDINECARBOXALDEHYDE manufacturers
- Product
- N-BOC-3-piperidine carboxyaldehyde 118156-93-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- 1-BOC-3-PIPERIDINECARBOXALDEHYDE 118156-93-7
- Price
- US $10.00-100.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000 Metric Ton/Month
- Release date
- 2024-03-19
- Product
- 1-Boc-3-Formylpiperidine 118156-93-7
- Price
- US $200.00/KG
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 500kg/month
- Release date
- 2021-12-17