1-Boc-3-hydroxypiperidine
- Product Name
- 1-Boc-3-hydroxypiperidine
- CAS No.
- 85275-45-2
- Chemical Name
- 1-Boc-3-hydroxypiperidine
- Synonyms
- TERT-BUTYL 3-HYDROXYPIPERIDINE-1-CARBOXYLATE;1-boc-3-piperidinol;RARECHEM EM WB 0260;N-BOC-3-PIPERIDINOL;Ibrutinib Impurity 57;Ibrutinib Impurity 126;BOC-3-HYDROXYPIPERIDINE;N-BOC-3-HYDOXYPIPERIDINE;N-Boc-3-hydroxypiperidin;1-BOC-3- hydroxypethidine
- CBNumber
- CB6125017
- Molecular Formula
- C10H19NO3
- Formula Weight
- 201.26
- MOL File
- 85275-45-2.mol
1-Boc-3-hydroxypiperidine Property
- Melting point:
- 65-67°C
- Boiling point:
- 292.3±33.0 °C(Predicted)
- Density
- 1.107±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 14.74±0.20(Predicted)
- color
- White to Almost white
- BRN
- 4180859
- InChI
- InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3
- InChIKey
- UIJXHKXIOCDSEB-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCCC(O)C1
- CAS DataBase Reference
- 85275-45-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B3278
- Product name
- 1-(tert-Butoxycarbonyl)-3-hydroxypiperidine
- Purity
- >98.0%(N)
- Packaging
- 1g
- Price
- $73
- Updated
- 2025/07/31
- Product number
- B656645
- Product name
- 1-Boc-3-Hydroxypiperidine
- Packaging
- 50g
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 07365
- Product name
- Boc-(,)-3-hydroxypiperidine
- Packaging
- 100G
- Price
- $125
- Updated
- 2021/12/16
- Product number
- FB49173
- Product name
- Boc-(R,S)-3-hydroxypiperidine
- Packaging
- 25g
- Price
- $126
- Updated
- 2021/12/16
- Product number
- K523
- Product name
- 1-Boc-3-Hydroxypiperidine
- Packaging
- 100g
- Price
- $74
- Updated
- 2021/12/16
1-Boc-3-hydroxypiperidine Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
It is a pharmaceutical intermediate.
Synthesis
6859-99-0
24424-99-5
85275-45-2
1) At room temperature, 3-hydroxypiperidine (5.00 g) was dissolved in methanol (50 mL), to which a methanol (50 mL) solution of triethylamine (15.2 mL) and di-tert-butyl dicarbonate (11.9 g) were sequentially added. The reaction mixture was stirred for 15 hours. After completion of the reaction, the solvent was removed by evaporation under reduced pressure and the resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate-chloroform) to afford tert-butyl 3-hydroxypiperidine-1-carboxylate as a white solid (9.86 g, 99% yield). The product was characterized by 1H-NMR (400 MHz, CDCl3) and EI-MS: 1H-NMR δ: 1.36-1.55 (2H, m), 1.45 (9H, s), 1.71-1.78 (1H, m), 1.88 (1H, m), 3.02-3.13 (2H, m), 3.52 (1H, m), 3.72-3.76 (2H, m); EI-MS m/z: 201 (M+).
References
[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 11, p. 3159 - 3171
[2] Patent: EP1762568, 2007, A1. Location in patent: Page/Page column 49-50
[3] Patent: EP1785418, 2007, A1. Location in patent: Page/Page column 47
[4] Patent: EP1107965, 2004, B1. Location in patent: Page 13
[5] Tetrahedron, 2011, vol. 67, # 7, p. 1485 - 1500
1-Boc-3-hydroxypiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Boc-3-hydroxypiperidine manufacturers
- Product
- 1-Boc-3-hydroxypiperidine 85275-45-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17
- Product
- N-BOC-3-hydroxypiperidine 85275-45-2
- Price
- US $100.00-2000.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 5MT per month
- Release date
- 2020-03-25
- Product
- 1-Boc-3-hydroxypiperidine 85275-45-2
- Price
- US $5.00-0.50/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-13