2-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Product Name: 2-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.: 157634-02-1
Chemical Name: 2-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms: tert-Butyl 2-formylpiperidine-1-carboxylate;N-BOC-2-CARBOXYALDEHYDE;1-Boc-2-formylpiperidine;N-BOC-2-FORMYLPIPERIDINE;1-N-Boc-2-Formylpiperidine;N-BOC-2-CARBOXYALDEHYDE 1G;N-BOC-PIPERIDINE-2-ALDEHYDE;1-BOC-2-PIPERIDINECARBALDEHYDE;1-Boc-piperidine-2-carbaldehyde;1-N-BOC-2-PIPERIDINECARBALDEHYDE
CBNumber: CB9172441
Molecular Formula: C11H19NO3
Formula Weight: 213.27
MOL File: 157634-02-1.mol

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2-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property

Boiling point:: 85-86°/0.06mm
Density: 1.114±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
form: solid
pka: -2.97±0.40(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C11H19NO3/c1-11(2,3)15-10(14)12-7-5-4-6-9(12)8-13/h8-9H,4-7H2,1-3H3
InChIKey: KZNDGAGWQPGYTB-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCCCC1C=O

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: B663868
Product name: N-Boc-2-piperidineCarboxyaldehyde
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 047977
Product name: tert-Butyl 2-formyltetrahydro-1(2H)-pyridinecarboxylate
Purity: 95%
Packaging: 1g
Price: $29
Updated: 2021/12/16

AK Scientific

Product number: J98880
Product name: N-Boc-2-piperidinecarboxyaldehyde
Packaging: 5g
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 047977
Product name: tert-Butyl 2-formyltetrahydro-1(2H)-pyridinecarboxylate
Purity: 95%
Packaging: 5g
Price: $99
Updated: 2021/12/16

Apolloscientific

Product number: OR300652
Product name: 1-tert-Butoxycarbonylpiperidine-2-carboxaldehyde
Purity: 97%
Packaging: 5g
Price: $135
Updated: 2021/12/16

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2-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

157634-00-9

157634-02-1

GENERAL STEPS: Synthesis Example 19; Synthesis of N-Substituted Aniline Intermediate XII; Purchased 1-Boc-2-piperidine methanol (1.4 g, 1 eq.) was dissolved in ethyl acetate (50 mL) and 2-iodobenzoic acid (3.4 g, 1.1 eq.) was added. The resulting slurry was stirred under inert atmosphere and DMSO (781 μL, 2.2 eq.) was added via syringe followed by stirring the reaction mixture overnight. After completion of the reaction, the solid impurities were removed by filtration and the filtrate was washed sequentially with a mixed solution of 10% Na2S2O3 and saturated NaHCO3 (1:1, 3 × 20 mL), water (1 × 20 mL) and brine (1 × 20 mL). The organic layer was concentrated under reduced pressure to give 1.3 g of 1-Boc-2-piperidine carboxaldehyde (94% yield). Subsequently, the resulting aldehyde (1.1 g, 1 eq.) was coupled with 4-fluoroaniline (481 μL, 1 eq.) dissolved in dichloroethane (20 mL). NaBH(OAc)3 (1.5 g, 1.4 eq.) and concentrated acetic acid (294 μL, 1 eq.) were added to the reaction mixture under an inert atmosphere, and the reaction process was monitored by TLC and LC-MS. After completion of the reaction, the reaction mixture was diluted with ethyl acetate, washed sequentially with 10% citric acid solution (3 × 20 mL), brine (1 × 20 mL), and the organic layer was dried with anhydrous magnesium sulfate. After filtration, the solvent was removed by rotary evaporation and the product was dried under vacuum to give 1.4 g of intermediate XII (90% yield).ESI-MS m/z = 309.1 [M + H]+.

References

[1] Tetrahedron, 2005, vol. 61, # 10, p. 2631 - 2643
[2] Organic Letters, 1999, vol. 1, # 4, p. 667 - 670
[3] Patent: US2010/210593, 2010, A1. Location in patent: Page/Page column 48
[4] Patent: EP2942346, 2015, A1. Location in patent: Paragraph 0173
[5] Tetrahedron Letters, 1996, vol. 37, # 13, p. 2165 - 2168

2-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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2-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

China 145 Germany 1 India 1 United Kingdom 4 United States 21 Global 172

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View Lastest Price from 2-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Wuhan Xinhao Biotechnology Co., Ltd

Product: 1-N-Boc-2-piperidinecarbaldehyde 157634-02-1
Price: US $10.00-100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 tons
Release date: 2024-03-11

Hebei Mingeng Biotechnology Co., Ltd

Product: 1-Boc-2-piperidinecarbaldehyde 157634-02-1
Price: US $150.00/kg
Min. Order: 10kg
Purity: 99%
Supply Ability: 500kg/month
Release date: 2022-05-06

Shanghai CRM New Material Technology Co., LTD

Product: 1-Boc-2-piperidinecarbaldehyde 157634-02-1
Price: US $10.00-15.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 2546245
Release date: 2022-09-16

157634-02-1, 2-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

Ethyl 1-Boc-piperidine-2-carboxylate (+/-)-1-N-BOC-PIPERIDINE-2-CARBOXAMIDE 4-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-BOC-3-PIPERIDINECARBOXALDEHYDE TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE Tert-butyl 2-cyanopiperazine-1-carboxylate 1-TERT-BUTYL 2-METHYL PIPERIDINE-1,2-DICARBOXYLATE N-BOC-3-Aminopiperidine N-Boc-4-piperidinemethanol N-BOC-piperidine-4-carboxylic acid N-Boc-2-piperidinecarboxylic acid Ethyl N-Boc-piperidine-4-carboxylate 1-Boc-3-hydroxypiperidine N-Boc-Piperidine-4-carboxylic acid methyl ester N-Boc-piperidine-3-methanol N-Boc-piperidine-2-methanol TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE 1-Boc-4-Methylaminopiperidine

N-BOC-2-FORMYLPIPERIDINE

2-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

1-BOC-2-PIPERIDINECARBALDEHYDE

1-N-Boc-2-piperidinecarboxaldehyde

N-BOC-PIPERIDINE-2-ALDEHYDE

1-Piperidinecarboxylic acid, 2-formyl-, 1,1-dimethylethyl ester

1-N-BOC-2-PIPERIDINECARBALDEHYDE

tert-butyl 2-formyltetrahydro-1(2H)-pyridinecarboxylate

N-Boc-2-piperidinecarboxaldehyde

tert-Butyl 2-formylpiperidine-1-carboxylate

1-Boc-2-formylpiperidine

N-tert-Butoxycarbonyl-2-piperidinecarboxaldehyde

N-BOC-2-piperidine carboxyaldehyde

1-Boc-2-Piperidinecarboxaldehyde

1-N-Boc-2-Formylpiperidine

tert-Butyl 2-forMylpiperidine-2-carboxylate

tert-Butyl 2-forMylpiperidine-3-carboxylate

tert-Butyl 2-forMylpiperidine-4-carboxylate

tert-Butyl 2-forMylpiperidine-5-carboxylate

tert-Butyl 2-forMylpiperidine-6-carboxylate

N-BOC-2-CARBOXYALDEHYDE

1-tert-Butoxycarbonylpiperidine-2-carbaldehyde

1-tert-Butoxycarbonylpiperidine-2-carboxaldehyde

1-Boc-piperidine-2-carbaldehyde

N-BOC-2-CARBOXYALDEHYDE 1G

1-tert-Butoxycarbonylpiperidine-2-carboxaldehyde 97%

2-Formyl-Piperidine-1-Carboxylic Acid Tert-Butyl Ester,>95%

N-Boc-2-piperidine carboxylaldehyde

1,1-Dimethylethyl 2-formyl-1-piperidinecarboxylate

<i>tert</i>-Butyl 2-formyltetrahydro-1(2<i>H</i>)-pyridinecarboxylate

tert-Butyl 2-formyl-1-piperidinecarboxylate

157634-02-1

157634-02-6

157634-02-5

157634-02-4

15763-02-1

157634-02-3

157634-02-2

Piperidine

pharmacetical