N-Boc-Piperidine-4-carboxylic acid methyl ester

Product Name: N-Boc-Piperidine-4-carboxylic acid methyl ester
CAS No.: 124443-68-1
Chemical Name: N-Boc-Piperidine-4-carboxylic acid methyl ester
Synonyms: 1-TERT-BUTYL 4-METHYL PIPERIDINE-1,4-DICARBOXYLATE;tert-Butyl methyl piperidine-1,4-dicarboxylate;ic acid methyL;N-Boc-4-Methylpiperidine;N-boc-4-methylpiperidinate;N-Boc-Piperidine-4-carboxyL;N-Boc- Piperidine-4-carboxylate;Methyl-boc-piperidine-4-carboxylate;N-Boc-Isonipecotic acid methyl ester;N-BOC-4-METHYL PIPERIDINECARBOXYLATE
CBNumber: CB7146350
Molecular Formula: C12H21NO4
Formula Weight: 243.3
MOL File: 124443-68-1.mol

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N-Boc-Piperidine-4-carboxylic acid methyl ester Property

Melting point:: 33.0 to 37.0 °C
Boiling point:: 307.4±35.0 °C(Predicted)
Density: 1.094±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Methanol
form: powder to lump
pka: -2.29±0.40(Predicted)
color: White to Light yellow
InChI: InChI=1S/C12H21NO4/c1-12(2,3)17-11(15)13-7-5-9(6-8-13)10(14)16-4/h9H,5-8H2,1-4H3
InChIKey: PTZNCCIULVXFIJ-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(C(OC)=O)CC1
CAS DataBase Reference: 124443-68-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2227
Product name: Methyl 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylate
Purity: >98.0%(GC)
Packaging: 1g
Price: $19
Updated: 2025/07/31

TCI Chemical

Product number: M2227
Product name: Methyl 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylate
Purity: >98.0%(GC)
Packaging: 5g
Price: $44
Updated: 2025/07/31

TRC

Product number: M330038
Product name: Methyl(1-BOC-piperidin-4-yl)carboxylate
Packaging: 2.5g
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 037710
Product name: 1-(tert-Butyl) 4-methyl tetrahydro-1,4(2H)-pyridinedicarboxylate
Purity: 95+%
Packaging: 25g
Price: $79
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB117301
Product name: 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate
Packaging: 100g
Price: $80
Updated: 2021/12/16

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N-Boc-Piperidine-4-carboxylic acid methyl ester Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

Methyl (1-BOC-piperidin-4-yl)carboxylate can be used as orexin type-2 receptor agonist.

Synthesis

67-56-1

84358-13-4

124443-68-1

General procedure for the synthesis of methyl 1-tert-butoxycarbonyl-4-piperidinecarboxylate from methanol and 1-Boc-4-piperidinecarboxylic acid: a hexane solution of trimethylmethylsilyl diazomethane (2.00 M, 52.9 mL, 106 mmol) was added slowly and dropwise at 0 °C to a 1-tert-butoxycarbonyl-piperidine-4-carboxylic acid (12.14 g, 52.95 mmol) acetonitrile ( 100 mL) suspension. Methanol (10 mL) was then added. The reaction mixture was allowed to stand at 0 °C for 30 min and then stirred at room temperature for 3 h. The reaction was carried out under reduced pressure. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was purified by column chromatography [hexane/ethyl acetate (4.5:1, v/v)] to afford 1-tert-butyl 4-methylpiperidine-1,4-dicarboxylate as a colorless oil (11.5 g, 90% yield). The structure of the product was confirmed by 1H NMR (400 MHz, d6-DMSO): δ 4.02 (dt, 2H, J = 3.5, 13.7 Hz), 3.69 (s, 3H), 2.82 (ddd, 2H, J = 3, 11.5, 14.5 Hz), 2.45 (tt, 1H, J = 3.9, 11.5 Hz), 1.90-1.84 ( m, 2H), 1.67-1.57 (m, 2H), 1.45 (s, 9H). Mass spectral analysis (ES) showed m/z 265.8 (MNa+); calculated value: 243.1 (M).

References

[1] Patent: WO2006/86609, 2006, A2. Location in patent: Page/Page column 160
[2] Tetrahedron Letters, 2004, vol. 45, # 12, p. 2663 - 2665
[3] Tetrahedron Letters, 2011, vol. 52, # 8, p. 849 - 852

N-Boc-Piperidine-4-carboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Boc-Piperidine-4-carboxylic acid methyl ester Suppliers

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View Lastest Price from N-Boc-Piperidine-4-carboxylic acid methyl ester manufacturers

Wuhan Xinhao Biotechnology Co., Ltd

Product: N-Boc-Piperidine-4-carboxylic acid methyl ester 124443-68-1
Price: US $10.00-100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 Metric Ton/Month
Release date: 2024-03-12

Anhui Zhongda Biotechnology Co., Ltd

Product: N-Boc-Piperidine-4-carboxylic acid methyl ester 124443-68-1
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100tons
Release date: 2023-10-26

Hebei Mingeng Biotechnology Co., Ltd

Product: N-Boc-Piperidine-4-carboxylic acid methyl ester 124443-68-1
Price: US $200.00/KG
Min. Order: 10g
Purity: 99%
Supply Ability: 500kg/month
Release date: 2021-12-16

124443-68-1, N-Boc-Piperidine-4-carboxylic acid methyl esterRelated Search:

Ethyl N-Boc-piperidine-4-carboxylate tert-Butyl acetate Tribenuron methyl Isonipecotic acid Methyl salicylate Methyl benzoate Methyl anthranilate Kresoxim-methyl tert-Butyl peroxyacetate Methyl carbamate Methyl acrylate tert-Butanol Methyl isonipecotate Methyl formate Methylparaben N-BOC-piperidine-4-carboxylic acid Thiophanate-methyl 1-TERT-BUTYL 2-METHYL PIPERIDINE-1,2-DICARBOXYLATE

tert-Butyl methyl piperidine-1,4-dicarboxylate

N-Boc-Isonipecotic acid methyl ester

1-(tert-butyl) 4-methyl tetrahydro-1,4(2H)-pyridinedicarboxylate

N-Boc- Piperidine-4-carboxylate

1-Boc-Piperidine-4-carboxylic acid methyl ester

1,4-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) 4-methyl ester

Methyl-boc-piperidine-4-carboxylate

Methyl 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylate

1-[(tert-butoxy)carbonyl]-4-Methylpiperidine-2-carboxylate

tert-Butyl Methyl piperidine-1,5-dicarboxylate

tert-Butyl Methyl piperidine-1,6-dicarboxylate

tert-Butyl Methyl piperidine-1,7-dicarboxylate

tert-Butyl Methyl piperidine-1,8-dicarboxylate

1-Boc-4-piperidinecarboxylic Acid Methyl Ester 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic Acid Methyl Ester 1-tert-Butyl 4-Methyl Piperidine-1,4-dicarboxylate Methyl 1-Boc-4-piperidinecarboxylate

tert-Butyl Methyl piperidine-1,9-dicarboxylate

N-Boc-Piperidine-4-carboxylate or 1-N-BOC-4-piperidinecarboxylic acid Methyl ester

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate, 1-(tert-Butoxycarbonyl)-4-(methoxycarbonyl)piperidine

N-BOC-PIPERIDINE-4-CARBOXYLIC ACID METHYL ESTER

N-BOC-4-METHYL PIPERIDINECARBOXYLATE

PIPERIDINE-1,4-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 4-METHYL ESTER

1-TERT-BUTYL 4-METHYL PIPERIDINE-1,4-DICARBOXYLATE

1-N-BOC-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER

Methyl 1-N-Boc-4-piperidinecarboxylate

Methyl1-tert-butoxycarbonylpiperidine-4-carboxyla

MethylN-Boc-4-piperidinecarboxylateG

Methyl N-Boc-piperidine-4-carboxylate

N-BOC-Piperidine-4-carboxylicacidmethyl

Methyl piperidine-4-carboxylate, N-BOC protected

N-BOC-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER

METHYL N-BOC-4-PIPERIDINECARBOXYLATE

METHYL N-BOC-PIPERIDIN-4-CARBOXYLATE

1-(tert-Butyl) 4-Methyl tetrahydro-1,4(2H)-pyridinedicarboxylate, 95+%

Methyl 1-(<i>tert</i>-butoxycarbonyl)-4-piperidinecarboxylate

1-tert-Butyl 4-methyl 1,4-piperidinedicarboxylate

O1-tert-butyl O4-methyl piperidine-1,4-dicarboxylate

piperidine-1,4-dicarboxylic acid O1-tert-butyl O4-methyl ester

1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic Acid Methyl Ester

Methyl1-(tert-Butoxycarbonyl)-4-piperidinecarboxylate&gt

ic acid methyL

N-Boc-Piperidine-4-carboxyL

N-Boc-piperidine-4-carboxylate, methyl ester

1-Boc-4-piperidinecarboxylic Acid Methyl Ester

Methyl 1-Boc-4-piperidinecarboxylate

Piperidine-1,4-dicarboxylic Acid 1-tert-Butyl 4-Methyl

1-O-tert-butyl 4-O-methyl piperidine-1,4-dicarboxylate

1-(1,1-Dimethylethyl) 4-methyl 1,4-piperidinedicarboxylate

N-boc-4-methylpiperidinate

N-Boc-Piperidine-4-Carboxylic Aacid Methyl Ester

Methyl N-Boc-4-piperidinecarboxylate, 95%

N-Boc-4-Methylpiperidine

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