1-Boc-4-Methylaminopiperidine

Product Name: 1-Boc-4-Methylaminopiperidine
CAS No.: 147539-41-1
Chemical Name: 1-Boc-4-Methylaminopiperidine
Synonyms: tert-butyl 4-(methylamino)piperidine-1-carboxylate;CAS:147539-41-1;BUTTPARK 90\06-11;N-BOC-4-METHYLAMINOPIERIDINE;1-Boc-4-methylaminopieridine;1-BOC-4-METHYLAMINOPIPERIDINE;N-BOC-4-METHYLAMINOPIPERIDINE;4-N-METHYLAMINO-1-BOC-PIPERIDINE;N-BOC-4-N-METHYLAMINO PIPERIDINE;1-N-BOC-4-(METHYLAMINO)PIPERIDINE
CBNumber: CB8302214
Molecular Formula: C11H22N2O2
Formula Weight: 214.3
MOL File: 147539-41-1.mol

More

Less

1-Boc-4-Methylaminopiperidine Property

Boiling point:: 289.0±33.0 °C(Predicted)
Density: 1.005 g/mL at 25 °C
refractive index: n20/D1.468
Flash point:: >110℃
storage temp.: 2-8°C
pka: 10.19±0.20(Predicted)
form: clear liquid
color: Colorless to Almost colorless
InChI: InChI=1S/C11H22N2O2/c1-11(2,3)15-10(14)13-7-5-9(12-4)6-8-13/h9,12H,5-8H2,1-4H3
InChIKey: CZYUGTLMFHDODF-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(NC)CC1
CAS DataBase Reference: 147539-41-1(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi,N,T
Risk Statements: 36/37/38-50-25
Safety Statements: 26-61-45-36/37/39
RIDADR: 2810
WGK Germany: 3
F: 10-34
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 29339900

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H400Very toxic to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 735671
Product name: 1-Boc-4-(methylamino)piperidine
Purity: 96%
Packaging: 500mg
Price: $84.2
Updated: 2023/01/07

TCI Chemical

Product number: B4015
Product name: 1-tert-Butoxycarbonyl-4-(methylamino)piperidine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $30
Updated: 2025/07/31

TCI Chemical

Product number: B4015
Product name: 1-tert-Butoxycarbonyl-4-(methylamino)piperidine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $81
Updated: 2025/07/31

TRC

Product number: B662050
Product name: 1-Boc-4-methylaminopiperidine
Packaging: 1g
Price: $55
Updated: 2021/12/16

Usbiological

Product number: 228705
Product name: 1-Boc-4-methylaminopiperidine
Packaging: 1g
Price: $186
Updated: 2021/12/16

More

Less

1-Boc-4-Methylaminopiperidine Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Uses

1-Boc-4-(methylamino)piperidine is used as an organic chemical synthesis intermediate.

Uses

1-Boc-4-methylaminopiperidine is a derivatieve of 3-Methylaminopiperidine Dihydrochloride, which is a a key intermediate for the antibacterial agent balofloxacin.

Synthesis

79099-07-3

74-89-5

147539-41-1

GENERAL STEPS: To a suspension of N-Boc-4-piperidone (10.00 g, 50.19 mmol) in ethanol (75 mL) was added 10% Pd/C catalyst (1.00 g, 10 wt%), methylamine (33% ethanol solution, 27 mL, 0.20 mol) and formic acid (46 mg, 1.00 mmol). The reaction mixture was placed in an autoclave, sealed under a hydrogen atmosphere at 4 MPa and stirred at 50°C overnight. After completion of the reaction, it was cooled to room temperature and filtered to remove the catalyst. The filtrate was concentrated in vacuum to afford 1-Boc-4-(methylamino)piperidine as a pale yellow liquid (10.70 g, 99% yield). Mass spectrum (ESI, cation mode) m/z: 215.3 [M + H]+; 1H NMR (400 MHz, CDCl3): δ (ppm) 4.01 (m, 2H), 2.79 (m, 2H), 2.48 (m, 1H), 2.42 (s, 3H), 1.83 (m, 2H), 1.44 (s, 9H), 1.28-1.15 (m, 2H).

References

[1] Patent: WO2015/73267, 2015, A1. Location in patent: Paragraph 332
[2] Patent: CN104650092, 2017, B. Location in patent: Paragraph 0533-0536
[3] Patent: US2006/160786, 2006, A1. Location in patent: Page/Page column 32
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 17, p. 4281 - 4285
[5] Patent: WO2005/7645, 2005, A1. Location in patent: Page 77

1-Boc-4-Methylaminopiperidine Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide Di-tert-butyl dicarbonate Methylamine Triethylamine Palladium 1,4-Dioxane Methylamine hydrochloride 1,2-Dichloroethane Methanol Sodium cyanoborohydride 4,4-Piperidinediol hydrochloride

Preparation Products

More

Less

1-Boc-4-Methylaminopiperidine Suppliers

Americas 1 China 176 Europe 2 Germany 3 India 5 Japan 2 United Kingdom 9 United States 41 Global 239

Shanghai Hobor Chemical Co., Ltd

Tel: 021-57790084; 13918007836
Fax: 021-51685238
Email: sales@hoborchem.com
Country: China
ProdList: 392
Advantage: 60

BTC Pharmaceutical CO. Ltd

Tel: 15716293042 18862996710
Fax: 0513-68015394
Email: 15050603958@163.com
Country: China
ProdList: 694
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

More

Less

View Lastest Price from 1-Boc-4-Methylaminopiperidine manufacturers

Honest Joy Holdings Limited

Product: 1-Boc-4-(Methylamino)piperidine 147539-41-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.7%
Supply Ability: 100 tons
Release date: 2022-02-08

Career Henan Chemical Co

Product: 1-Boc-4-Methylaminopiperidine 147539-41-1
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200kg
Release date: 2018-12-17

147539-41-1, 1-Boc-4-MethylaminopiperidineRelated Search:

tert-butyl 4-(difluoroMethyl)piperidine-1-carboxylate 1-Boc-4-(aminomethyl)piperidine 1-TERT-BUTYL 2-METHYL PIPERIDINE-1,2-DICARBOXYLATE N-BOC-3-Aminopiperidine 1-BOC-3-PIPERIDINECARBOXALDEHYDE N-Boc-4-piperidinemethanol (+/-)-1-N-BOC-PIPERIDINE-2-CARBOXAMIDE 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde N-BOC-piperidine-4-carboxylic acid N-Boc-2-piperidinecarboxylic acid Ethyl N-Boc-piperidine-4-carboxylate Ethyl 1-Boc-piperidine-2-carboxylate 1-Boc-3-hydroxypiperidine N-Boc-Piperidine-4-carboxylic acid methyl ester N-Boc-piperidine-3-methanol N-Boc-piperidine-2-methanol TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE 1-N-BOC-PIPERIDINE-3-CARBOXAMIDE

N-BOC-4-METHYLAMINOPIERIDINE

N-BOC-4-METHYLAMINOPIPERIDINE

N-BOC-4-N-METHYLAMINO PIPERIDINE

tert-butyl 4-(methylamino)piperidine-1-carboxylate

4-N-METHYLAMINO-1-BOC-PIPERIDINE

4-METHYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

BUTTPARK 90\06-11

1-N-BOC-4-(METHYLAMINO)PIPERIDINE

1-BOC-4-METHYLAMINOPIPERIDINE

1-TERT-BUTYLOXYCARBONYL-4-AMINOMETHYL-PIPERIDINE

1-Piperidinecarboxylic acid, 4-(methylamino)-, 1,1-dimethylethyl ester

1-Boc-4-methyl-aminopiperidine tert-butyl 4-(methylamino)piperidine-1-carboxylate

1-BOC-4-METHYLAMINOPIPERIDINE, 98+%

1-t-Butyloxycarbonyl-4-(aminomethyl)-piperidine hydrochloride

4-(Methylamino)piperidine, N1-BOC protected

tert-butyl 4-(methylamino)piperidine-1-carboxylate hydrochloride

tert-Butyl 4-(methylamino)piperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-(methylamino)piperidine

1-Boc-4-methylaminopieridine

1-tert-Butoxycarbonyl-4-(MethylaMino)piperidine

1-Boc-4-(methylamino)piperidine,97%

1-tert-Butoxycarbonyl-4-(methylamino)piperidine &gt

4-Methylamino-1-piperidinecarboxylic Acid tert-Butyl Ester

tert-Butyl 4-Methylamino-1-piperidinecarboxylate

CAS:147539-41-1

1-Boc-4-Methylaminopiperidine, CAS 147539-41-1

147539-41-1

pharmacetical

Piperidine