TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE

Uses

Product Name: TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE
CAS No.: 91419-48-6
Chemical Name: TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE
Synonyms: 4-carbamoyL;BUTTPARK 95\06-10;N-BOC isonipecotamide;1-N-BOC-ISONIPECOTAMIDE;Revefenacin Impurity 43;1-Boc-4-carbamoylpiperidine;N-BOC-4-PieridinecarboxaMide;Boc-piperidine-4-carboxylate;1-Boc-4-Piperidinecarboxamide;N-BOC-4-PiperidineCarboxamide
CBNumber: CB8139012
Molecular Formula: C11H20N2O3
Formula Weight: 228.29
MOL File: 91419-48-6.mol

More

Less

TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE Property

Melting point:: 158-160
Boiling point:: 384.4±31.0 °C(Predicted)
Density: 1.123±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: 16.40±0.20(Predicted)
color: White to Almost white
InChI: InChI=1S/C11H20N2O3/c1-11(2,3)16-10(15)13-6-4-8(5-7-13)9(12)14/h8H,4-7H2,1-3H3,(H2,12,14)
InChIKey: YHFUWPUJUMZXBD-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(C(N)=O)CC1

More

Less

Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 29333990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: B3892
Product name: 1-(tert-Butoxycarbonyl)-4-piperidinecarboxamide
Purity: >97.0%(GC)(N)
Packaging: 1g
Price: $24
Updated: 2025/07/31

TCI Chemical

Product number: B3892
Product name: 1-(tert-Butoxycarbonyl)-4-piperidinecarboxamide
Purity: >97.0%(GC)(N)
Packaging: 5g
Price: $96
Updated: 2025/07/31

TRC

Product number: B809648
Product name: tert-Butyl4-carbamoylpiperidine-1-carboxylate
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB39710
Product name: 1-N-Boc-4-piperidinecarboxamide
Packaging: 1g
Price: $79
Updated: 2021/12/16

Chem-Impex

Product number: 43433
Product name: 1-(tert-Butoxycarbonyl)-4-piperidinecarboxamide,≥97%(GC)
Purity: ≥97%(GC)
Packaging: 1G
Price: $20.8
Updated: 2021/12/16

More

Less

TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE Chemical Properties,Usage,Production

Uses

1-BOC-piperidine-4-carboxamide is a common organic synthon in which the Boc group can be removed under acidic conditions, releasing the cyclohexylamine structure. Furthermore, the formamide structure on the ring can be converted to a cyano group under certain reaction conditions; and the oxygen atom on the formamide can be converted to a sulfur atom by the action of Lawesson reagent.

Chemical Properties

White powder

Synthesis

84358-13-4

91419-48-6

General procedure for the synthesis of tert-butyl 4-carbamoylpiperidine-1-carboxylate from 1-Boc-4-piperidinecarboxylic acid: a mixture of 1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid (220 mg, 2.88 mmol), ammonium chloride (154 mg, 2.88 mmol), EDCI (367 mg, 1.92 mmol) and HOAT (195 mg. 1.44 mmol) were dissolved in dichloromethane (10 mL) at 0 °C, followed by dropwise addition of DIPEA (1.0 mL, 5.77 mmol). After dropwise addition, the reaction mixture was stirred at room temperature for 10 hours. After completion of the reaction, the reaction mixture was washed with distilled water (10 mL x 3). The organic layer was separated and dried with anhydrous Na2SO4 and subsequently concentrated under reduced pressure. The residue was purified by silica gel column chromatography using ethyl acetate as eluent to afford tert-butyl 4-carbamoylpiperidine-1-carboxylate as a white solid (160 mg, 73% yield).1H NMR (400 MHz, CD3OD): δ 4.11 (d, J = 13.4 Hz, 2H), 2.76-2.86 (m, 2H), 2.38-2.45 ( m, 1H), 1.79 (d, J = 11.2 Hz, 2H), 1.52-1.62 (m, 2H), 1.47 (s, 9H).MS-ESI: m/z 173.20 [M-55]+.

References

[1] Patent: WO2016/34134, 2016, A1. Location in patent: Paragraph 00539
[2] Patent: CN105399698, 2016, A. Location in patent: Paragraph 1621-1623
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 23, p. 9196 - 9213
[4] Patent: WO2015/48662, 2015, A2. Location in patent: Page/Page column 114
[5] European Journal of Medicinal Chemistry, 1984, vol. 19, # 2, p. 181 - 186

TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE Suppliers

Americas 1 Belgium 2 Canada 1 China 195 Europe 1 France 1 Germany 5 India 5 Japan 1 Switzerland 2 The Netherlands 1 United Kingdom 6 United States 36 Global 257

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Ark Pharm, Inc.

Tel: 847-367-3680
Fax: 847-367-3681
Email: sales@arkpharminc.com
Country: United States
ProdList: 1670
Advantage: 56

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd.

Tel: 21-54820552 18964669552
Fax: 086-21-64964478
Email: 188738128@qq.com
Country: China
ProdList: 310
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

More

Less

View Lastest Price from TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE manufacturers

Anhui Yiao New Material Technology Co., Ltd

Product: 1-N-BOC-ISONIPECOTAMIDE 91419-48-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1 ton
Release date: 2023-11-02

Anhui Yiao New Material Technology Co., Ltd

Product: 1-N-BOC-ISONIPECOTAMIDE 91419-48-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1 ton
Release date: 2023-11-02

Anhui Yiao New Material Technology Co., Ltd

Product: 1-N-BOC-ISONIPECOTAMIDE 91419-48-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1 ton
Release date: 2023-11-02

91419-48-6, TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATERelated Search:

1-N-BOC-PIPERIDINE-3-CARBOXAMIDE 1-Boc-4-cyanopiperidine (+/-)-1-N-BOC-PIPERIDINE-2-CARBOXAMIDE 1-TERT-BUTYL 2-METHYL PIPERIDINE-1,2-DICARBOXYLATE N-BOC-3-Aminopiperidine 1-BOC-3-PIPERIDINECARBOXALDEHYDE N-Boc-4-piperidinemethanol 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde N-BOC-piperidine-4-carboxylic acid N-Boc-2-piperidinecarboxylic acid Ethyl N-Boc-piperidine-4-carboxylate Ethyl 1-Boc-piperidine-2-carboxylate 1-Boc-3-hydroxypiperidine N-Boc-Piperidine-4-carboxylic acid methyl ester N-Boc-piperidine-3-methanol N-Boc-piperidine-2-methanol 1-Boc-4-Methylaminopiperidine 1-Boc-3-piperidone

1-Piperidinecarboxylic acid, 4-(aminocarbonyl)-, 1,1-dimethylethyl ester

1-N-BOC-ISONIPECOTAMIDE

1-Boc-4-Piperidinecarboxamide

tert-Butyl 4-(aminocarbonyl)tetrahydropyridine-1-carboxylate

N-BOC-piperidine-4-carboxamide

tert-butyl 4-carbaMoylpiperidine-1-carboxylate

4-Carbamoylpiperidine, N1-BOC protected

tert-Butyl 4-carbamoylpiperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-carbamoylpiperidine, 1-(tert-Butoxycarbonyl)piperidine-4-carboxamide

Tert-butyl 4-(aMinocarbony)tetrahydropyridine-1 (2H)-carboxylate

N-BOC-4-PieridinecarboxaMide

1-Boc-4-(aMinocarbonyl)-piperidine

1-(tert-Butoxycarbonyl)-4-piperidinecarboxaMide

4-CarbaMoyl-piperidine-1-carboxylicacidtert-butylester

tert-Butyl 4-carbaMoylpiperidine-1-carboxylate,97+%

Boc-piperidine-4-carboxylate

1-Boc-4-carbamoylpiperidine

1-(TERT-BUTOXYCARBONYL)PIPERIDINE-4-CARBOXAMIDE

tert-butyl N-[(piperidin-4-yl)carbonyl]carbaMate

tert-Butyl 4-(aminocarbonyl)-piperidine-1-carboxylate

1-N-BOC-PIPERIDINE-4-CARBOXAMIDE

BUTTPARK 95\06-10

TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE

1-N-Boc-4-piperidinecarboxamide

1-BOC-piperidine-4-carboxamide

N-BOC-4-PiperidineCarboxamide

1-(tert-Butoxycarbonyl)-4-piperidinecarboxamide &gt

4-carbamoyL

N-BOC isonipecotamide

N-boc - piperidine -4- carboxylamide

4-Carbamoyl-1-piperidinecarboxylic Acid tert-Butyl Ester

tert-Butyl 4-Carbamoyl-1-piperidinecarboxylate

1-TERT-BUTYLOXYCARBONYL PIPERIDINE-4-CARBOXYLIC ACIDAMIDE

tert-butyl 4-(aminocarbonyl)tetrahydropyridine-1(2H)-carboxy...

1,1-Dimethylethyl 4-(aminocarbonyl)-1-piperidinecarboxylate

Raffenacin impurity 37 (1-boc-piperidine-4-carboxamide)

Revefenacin Impurity 43

tert-Butyl 4-(aminocarbonyl)-1-piperidinecarboxylate

91419-48-6

91419-49-8

91419-48-6