ChemicalBook > CAS DataBase List > TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE

TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE

Uses

Product Name: TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE
CAS No.: 91419-48-6
Chemical Name: TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE
Synonyms: 4-carbamoyL;BUTTPARK 95\06-10;N-BOC isonipecotamide;1-N-BOC-ISONIPECOTAMIDE;Revefenacin Impurity 43;1-Boc-4-carbamoylpiperidine;N-BOC-4-PieridinecarboxaMide;Boc-piperidine-4-carboxylate;1-Boc-4-Piperidinecarboxamide;N-BOC-4-PiperidineCarboxamide
CBNumber: CB8139012
Molecular Formula: C11H20N2O3
Formula Weight: 228.29
MOL File: 91419-48-6.mol

Less

TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE Property

Melting point:: 158-160
Boiling point:: 384.4±31.0 °C(Predicted)
Density: 1.123±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: 16.40±0.20(Predicted)
color: White to Almost white
InChI: InChI=1S/C11H20N2O3/c1-11(2,3)16-10(15)13-6-4-8(5-7-13)9(12)14/h8H,4-7H2,1-3H3,(H2,12,14)
InChIKey: YHFUWPUJUMZXBD-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(C(N)=O)CC1

Less

Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 29333990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: B3892
Product name: 1-(tert-Butoxycarbonyl)-4-piperidinecarboxamide
Purity: >97.0%(GC)(N)
Packaging: 1g
Price: $24
Updated: 2025/07/31

TCI Chemical

Product number: B3892
Product name: 1-(tert-Butoxycarbonyl)-4-piperidinecarboxamide
Purity: >97.0%(GC)(N)
Packaging: 5g
Price: $96
Updated: 2025/07/31

TRC

Product number: B809648
Product name: tert-Butyl4-carbamoylpiperidine-1-carboxylate
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB39710
Product name: 1-N-Boc-4-piperidinecarboxamide
Packaging: 1g
Price: $79
Updated: 2021/12/16

Chem-Impex

Product number: 43433
Product name: 1-(tert-Butoxycarbonyl)-4-piperidinecarboxamide,≥97%(GC)
Purity: ≥97%(GC)
Packaging: 1G
Price: $20.8
Updated: 2021/12/16

Less

TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE Chemical Properties,Usage,Production

Uses

1-BOC-piperidine-4-carboxamide is a common organic synthon in which the Boc group can be removed under acidic conditions, releasing the cyclohexylamine structure. Furthermore, the formamide structure on the ring can be converted to a cyano group under certain reaction conditions; and the oxygen atom on the formamide can be converted to a sulfur atom by the action of Lawesson reagent.

Chemical Properties

White powder

Synthesis

84358-13-4

91419-48-6

General procedure for the synthesis of tert-butyl 4-carbamoylpiperidine-1-carboxylate from 1-Boc-4-piperidinecarboxylic acid: a mixture of 1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid (220 mg, 2.88 mmol), ammonium chloride (154 mg, 2.88 mmol), EDCI (367 mg, 1.92 mmol) and HOAT (195 mg. 1.44 mmol) were dissolved in dichloromethane (10 mL) at 0 °C, followed by dropwise addition of DIPEA (1.0 mL, 5.77 mmol). After dropwise addition, the reaction mixture was stirred at room temperature for 10 hours. After completion of the reaction, the reaction mixture was washed with distilled water (10 mL x 3). The organic layer was separated and dried with anhydrous Na2SO4 and subsequently concentrated under reduced pressure. The residue was purified by silica gel column chromatography using ethyl acetate as eluent to afford tert-butyl 4-carbamoylpiperidine-1-carboxylate as a white solid (160 mg, 73% yield).1H NMR (400 MHz, CD3OD): δ 4.11 (d, J = 13.4 Hz, 2H), 2.76-2.86 (m, 2H), 2.38-2.45 ( m, 1H), 1.79 (d, J = 11.2 Hz, 2H), 1.52-1.62 (m, 2H), 1.47 (s, 9H).MS-ESI: m/z 173.20 [M-55]+.

References

[1] Patent: WO2016/34134, 2016, A1. Location in patent: Paragraph 00539
[2] Patent: CN105399698, 2016, A. Location in patent: Paragraph 1621-1623
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 23, p. 9196 - 9213
[4] Patent: WO2015/48662, 2015, A2. Location in patent: Page/Page column 114
[5] European Journal of Medicinal Chemistry, 1984, vol. 19, # 2, p. 181 - 186

TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE Suppliers

Americas 1 Belgium 2 Canada 1 China 194 Europe 1 France 1 Germany 5 India 5 Japan 1 Switzerland 2 The Netherlands 1 United Kingdom 6 United States 36 Global 256

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd.

Tel: 21-54820552 18964669552
Fax: 086-21-64964478
Email: 188738128@qq.com
Country: China
ProdList: 310
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9309
Advantage: 66

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Shanghai Harvest Chemical Industrial Co., Ltd.

Tel: 021-31038972,31038973 17321035817
Fax: +86-21-51385350
Email: sales@harvest-chem.com
Country: China
ProdList: 2816
Advantage: 64

Shanghai Chiral Chemicals Inc.

Tel: 021-37285021 13472570865
Fax: 86-021-51714507
Email: tym7xi@aliyun.com
Country: China
ProdList: 308
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16077
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 7247
Advantage: 62

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.

Tel: 022-60116533 13207668525
Fax: 022-60979672
Email: saleskc@scipharmacn.com
Country: China
ProdList: 603
Advantage: 58

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Nanjing JinruiJiuAn Biotechnology Co., Ltd.

Tel: 025-58196018 800028039
Fax: 025-83453306
Email: sales@fartop.net
Country: China
ProdList: 2229
Advantage: 55

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.

Tel: 21-33585366 13311639313
Fax: +86-21-34979012
Email: sales@shyrchem.com
Country: China
ProdList: 806
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Nanjing Junnahe Biopharmaceutical Co., Ltd

Tel: 025-58367986 17351780683
Fax: QQ3209878052
Email: amy.xiang@ally-chem.com
Country: China
ProdList: 354
Advantage: 60

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: 15928766785 15928766785
Fax: QQ961458712
Email: wupengcheng@astatech.cn
Country: China
ProdList: 1987
Advantage: 55

Anhui Dexinjia Biopharm Co., Ltd

Tel: 0531-82375892 15553111391
Email: 3276840968@qq.com
Country: China
ProdList: 301
Advantage: 58

Shanghai XIYU Chemical Technology Co.,Ltd.

Tel: 021-15000143735 15221126179
Fax: 021-38473230
Email: sala@xiyuchem.com
Country: China
ProdList: 375
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828 4008675858
Fax: +86-512-56316826
Email: sales@amateksci.com
Country: China
ProdList: 9874
Advantage: 55

Shanghai Meishui Chemical Technology Co., Ltd

Tel: 021-60549325 18616193163
Fax: 021-33250306
Country: China
ProdList: 4526
Advantage: 56

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai Hobor Chemical Co., Ltd

Tel: 021-57790084; 13918007836
Fax: 021-51685238
Email: sales@hoborchem.com
Country: China
ProdList: 392
Advantage: 60

Chengdu Firster Pharmaceutical Co., Ltd.

Tel: 028-87078428 028-87074958
Fax: 8772-8116
Email: chengzhenyong@cdfirster.com
Country: China
ProdList: 2598
Advantage: 60

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Beijing FYF Chemicals Co., Ltd

Tel: 010-57903446 15869909019
Fax: 010-57903446
Email: 168931144@qq.com
Country: China
ProdList: 2875
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

Shanghai Song Yuan Chemical Technology Co., Ltd.

Tel: 010-1234567 18521000990
Fax: 86-021-33275113
Email: sonyuanchemical@163.com
Country: China
ProdList: 6479
Advantage: 50

Nanjing Chalf-Pharm Technology Co., Ltd.

Tel: 025-57018978 18251899859
Fax: 025-57018008
Email: sales@chalf-pharm.com
Country: China
ProdList: 5674
Advantage: 50

Shanghai Tombiopharma Chemical Co. Ltd.

Tel: 13391076197
Email: tombiopharma@163.com
Country: China
ProdList: 4987
Advantage: 55

Sichuan Argalbio Technology Co,.Ltd

Tel: 028-028-60651388 13330964498
Email: slyu@hengkangtech.com
Country: China
ProdList: 378
Advantage: 58

Quzhou Rundong Chemical (Technology) Co.

Tel: 0570-8789886 18892685668
Fax: 0570-8789985
Email: info@rundongchemical.com
Country: China
ProdList: 4053
Advantage: 60

SanoChem (Chengdu) Tech. Co., Ltd.

Tel: 28-87999436 02887999436
Fax: QQ:2746983436
Email: sales@sano-chem.com
Country: China
ProdList: 3795
Advantage: 55

JW & Y Pharmlab Co., Ltd.

Tel: 021-64340559 13651849907;
Fax: 021- 64345308
Email: xinyu_shi@jwypharmlab.com.cn
Country: China
ProdList: 12000
Advantage: 58

Chengdu jingzhihuacheng Chemical Technology Co., Ltd.

Tel: 028-028-37664989 15900794981
Email: jingzhichem@163.com
Country: China
ProdList: 537
Advantage: 55

Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
Email: 2853979813@qq.com
Country: China
ProdList: 7991
Advantage: 55

Less

View Lastest Price from TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE manufacturers

Anhui Yiao New Material Technology Co., Ltd

Product: 1-N-BOC-ISONIPECOTAMIDE 91419-48-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1 ton
Release date: 2023-11-02

Anhui Yiao New Material Technology Co., Ltd

Product: 1-N-BOC-ISONIPECOTAMIDE 91419-48-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1 ton
Release date: 2023-11-02

Anhui Yiao New Material Technology Co., Ltd

Product: 1-N-BOC-ISONIPECOTAMIDE 91419-48-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1 ton
Release date: 2023-11-02

91419-48-6, TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATERelated Search:

1-N-BOC-PIPERIDINE-3-CARBOXAMIDE 1-Boc-4-cyanopiperidine (+/-)-1-N-BOC-PIPERIDINE-2-CARBOXAMIDE 1-TERT-BUTYL 2-METHYL PIPERIDINE-1,2-DICARBOXYLATE N-BOC-3-Aminopiperidine 1-BOC-3-PIPERIDINECARBOXALDEHYDE N-Boc-4-piperidinemethanol 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde N-BOC-piperidine-4-carboxylic acid N-Boc-2-piperidinecarboxylic acid Ethyl N-Boc-piperidine-4-carboxylate Ethyl 1-Boc-piperidine-2-carboxylate 1-Boc-3-hydroxypiperidine N-Boc-Piperidine-4-carboxylic acid methyl ester N-Boc-piperidine-3-methanol N-Boc-piperidine-2-methanol 1-Boc-4-Methylaminopiperidine 1-Boc-3-piperidone

1-Piperidinecarboxylic acid, 4-(aminocarbonyl)-, 1,1-dimethylethyl ester

1-N-BOC-ISONIPECOTAMIDE

1-Boc-4-Piperidinecarboxamide

tert-Butyl 4-(aminocarbonyl)tetrahydropyridine-1-carboxylate

N-BOC-piperidine-4-carboxamide

tert-butyl 4-carbaMoylpiperidine-1-carboxylate

4-Carbamoylpiperidine, N1-BOC protected

tert-Butyl 4-carbamoylpiperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-carbamoylpiperidine, 1-(tert-Butoxycarbonyl)piperidine-4-carboxamide

Tert-butyl 4-(aMinocarbony)tetrahydropyridine-1 (2H)-carboxylate

N-BOC-4-PieridinecarboxaMide

1-Boc-4-(aMinocarbonyl)-piperidine

1-(tert-Butoxycarbonyl)-4-piperidinecarboxaMide

4-CarbaMoyl-piperidine-1-carboxylicacidtert-butylester

tert-Butyl 4-carbaMoylpiperidine-1-carboxylate,97+%

Boc-piperidine-4-carboxylate

1-Boc-4-carbamoylpiperidine

1-(TERT-BUTOXYCARBONYL)PIPERIDINE-4-CARBOXAMIDE

tert-butyl N-[(piperidin-4-yl)carbonyl]carbaMate

tert-Butyl 4-(aminocarbonyl)-piperidine-1-carboxylate

1-N-BOC-PIPERIDINE-4-CARBOXAMIDE

BUTTPARK 95\06-10

TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE

1-N-Boc-4-piperidinecarboxamide

1-BOC-piperidine-4-carboxamide

N-BOC-4-PiperidineCarboxamide

1-(tert-Butoxycarbonyl)-4-piperidinecarboxamide &gt

4-carbamoyL

N-BOC isonipecotamide

N-boc - piperidine -4- carboxylamide

4-Carbamoyl-1-piperidinecarboxylic Acid tert-Butyl Ester

tert-Butyl 4-Carbamoyl-1-piperidinecarboxylate

1-TERT-BUTYLOXYCARBONYL PIPERIDINE-4-CARBOXYLIC ACIDAMIDE

tert-butyl 4-(aminocarbonyl)tetrahydropyridine-1(2H)-carboxy...

1,1-Dimethylethyl 4-(aminocarbonyl)-1-piperidinecarboxylate

Raffenacin impurity 37 (1-boc-piperidine-4-carboxamide)

Revefenacin Impurity 43

tert-Butyl 4-(aminocarbonyl)-1-piperidinecarboxylate

91419-48-6

91419-49-8

91419-48-6