4-N-BOC-Aminopiperidine

Description

Product Name: 4-N-BOC-Aminopiperidine
CAS No.: 73874-95-0
Chemical Name: 4-N-BOC-Aminopiperidine
Synonyms: TERT-BUTYL PIPERIDIN-4-YLCARBAMATE;tert-Butyl N-(4-piperidyl)carbaMate;tert-butyl N-(piperidin-4-yl)carbaMate;PIPERIDIN-4-YL-CARBAMIC ACID TERT-BUTYL ESTER;4-BOC-AMINOPIPERIDINE;4-(N-BOC-AMINO)PIPERIDINE;Prucapride 11;BUTTPARK 90\06-01;4-N-BOC-AMinopiperid;BOC-4-AMINOPIPERIDINE
CBNumber: CB9192199
Molecular Formula: C10H20N2O2
Formula Weight: 200.28
MOL File: 73874-95-0.mol

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4-N-BOC-Aminopiperidine Property

Melting point:: 162-166 °C(lit.)
Boiling point:: 80°C/0.05mm
Density: 1.02±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
pka: 12.39±0.20(Predicted)
form: Crystalline Powder
color: Off-white
Sensitive: Air Sensitive
InChI: InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-8-4-6-11-7-5-8/h8,11H,4-7H2,1-3H3,(H,12,13)
InChIKey: CKXZPVPIDOJLLM-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NC1CCNCC1
CAS DataBase Reference: 73874-95-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 540935
Product name: 4-(N-Boc-amino)piperidine
Purity: 96%
Packaging: 1g
Price: $22.24
Updated: 2025/07/31

Sigma-Aldrich

Product number: 540935
Product name: 4-(N-Boc-amino)piperidine
Purity: 96%
Packaging: 5g
Price: $34.3
Updated: 2025/07/31

TCI Chemical

Product number: B2319
Product name: 4-(tert-Butoxycarbonylamino)piperidine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $17
Updated: 2025/07/31

TCI Chemical

Product number: B2319
Product name: 4-(tert-Butoxycarbonylamino)piperidine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $30
Updated: 2025/07/31

Cayman Chemical

Product number: 30398
Product name: 4-(N-Boc-amino)piperidine
Packaging: 1g
Price: $37
Updated: 2024/03/01

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4-N-BOC-Aminopiperidine Chemical Properties,Usage,Production

Description

4-(N-Boc-amino)piperidone may be used as a functionalization reagent for introduction of a primary and a tertiary amino group to poly(2-isopropyl-2-oxazoline. It can also be used as pharma building block. It is used in the synthesis of a piperidine-4-carboxamide CCR5 antagonist with potent anti-HIV 1-activity. It is an intermediate for the synthesis of various pharmaceutical and biologically active compounds, including inhibitors and therapeutic agents. It is used for the synthesis of diphenyl purine derivatives as peripherally selective cannabinoid receptor 1 Antagonists.

Chemical Properties

off-white crystalline powder

Uses

Pharma building block.

General Description

4-(N-Boc-amino)piperidone is a piperidone derivative.

Synthesis

73889-19-7

73874-95-0

General procedure for the synthesis of 4-tert-butoxycarbonylaminopiperidine from tert-butyl (1-benzylpiperidin-4-yl)carbamate: N-butyl-1-benzylpiperidin-4-ylcarbamate (3.80 g, 13.1 mmol) was dissolved in 26 mL of methanol in a 100 mL reaction vessel. A catalytic amount of 10% palladium/carbon (Pd/C) was added. The reaction was stirred under hydrogen atmosphere for 12 hours. Upon completion of the reaction, the palladium/carbon catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure to remove the solvent. The resulting residue was purified by silica gel column chromatography to afford 4-tert-butoxycarbonylaminopiperidine (2.64 g, 99% yield). The product was confirmed by 1H-NMR (200 MHz, CD3OD): δ 1.36 (s, 9H), 1.84-2.36 (m, 4H), 2.74 (m, 2H), 3.42 (m, 2H), 3.60 (br, 1H).LC/MS analysis showed the [M+H]+ peak as 201.

References

[1] Patent: WO2008/54154, 2008, A1. Location in patent: Page/Page column 33; 34; 76; 77; 162-164
[2] Patent: WO2007/52938, 2007, A1. Location in patent: Page/Page column 18
[3] Journal of Medicinal Chemistry, 1999, vol. 42, # 14, p. 2706 - 2715
[4] Patent: WO2007/46550, 2007, A1. Location in patent: Page/Page column 117
[5] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 24, p. 5345 - 5352

4-N-BOC-Aminopiperidine Preparation Products And Raw materials

Raw materials

1,1'-Carbonyldiimidazole Hydrazinium hydroxide solution Acetone Di-tert-butyl dicarbonate Potassium carbonate 2,3-DICHLORO-5,8-DIHYDROXY-1,4-NAPHTHOQUINONE Chloroform Palladium Sodium nitrite Methyl isonipecotate Benzyl bromide Ethyl acetate Hydrochloric acid Isonipecotic acid Bromine Acetic acid Methanol

Preparation Products

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4-N-BOC-Aminopiperidine Suppliers

Americas 1 Belgium 2 Canada 1 China 359 Europe 4 France 3 Germany 10 India 45 Japan 4 Slovakia 1 South Korea 1 Sweden 1 Switzerland 3 Ukraine 2 United Kingdom 16 United States 77 Global 530

Sichuan Argalbio Technology Co,.Ltd

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View Lastest Price from 4-N-BOC-Aminopiperidine manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: 4-Boc-aminopiperidine 73874-95-0
Price: US $1.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99.5% HPLC
Supply Ability: 500KG/MONTH
Release date: 2021-05-25

Anhui Yiao New Material Technology Co., Ltd

Product: 4-N-(tert-Butoxycarbonyl)aminopiperidine 73874-95-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1 ton
Release date: 2023-11-02

Anhui Yiao New Material Technology Co., Ltd

Product: 4-N-(tert-Butoxycarbonyl)aminopiperidine 73874-95-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1 ton
Release date: 2023-11-02

73874-95-0, 4-N-BOC-AminopiperidineRelated Search:

1-Aminopiperidine DROPERIDOL Haloperidol 3-N-Boc-aminopiperidine tert-butyl thiazol-4-ylcarbamate (1R,4R)-(4-MethylaMino-cyclohexyl)-carbaMic acid tert-butyl ester 1-Oxa-6-azaspiro[3.3]heptane-6-carboxylic acid, 3,3-diMethyl-, 1,1-diMethylethyl ester tert-butyl((5-carbamoyl-1-methyl-1H-pyrazol-3-yl)methyl)(methyl)carbamate DI-TERT-BUTYL ETHER Carbamic acid, N-methyl-N-[(3-nitrophenyl)methyl]-, 1,1-dimethylethyl ester 4-AMINO-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID 4-TERT-BUTOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONOBENZYL ESTER 4-N-Boc-4-N-Methyl-aminopiperidine 1-BENZYL-4-(N-BOC-AMINO) PIPERIDINE 98 4-TERT-BUTOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER Diphenoxylate (R)-3-(Boc-Amino)piperidine (R)-1-Benzyl-3-N-Boc-aminopiperidine

4-(TERT-BUTOXYCARBONYLAMINO)PIPERIDINE

4-N-TERT-BOC-AMINO PIPERIDINE

4-N-(TERT-BUTOXYCARBONYL)AMINOPIPERIDINE

4-BOC-AMINOPIPERIDINE

4-AMINOPIPERIDINE, 4-BOC PROTECTED

4-(N-BOC-AMINO)PIPERIDINE

4-(tert-ButoxycarbonylaMino)piperidine, 98.0%(GC&T

CARBAMIC ACID, 4-PIPERIDINYL-, 1,1-DIMETHYLETHYL ESTER

BUTTPARK 90\06-01

BOC-4-AMINOPIPERIDINE

4 - bok - aMino piperidine

4-N-BOC-AMinopiperidine SynonyMs 4-N-(tert-Butoxycarbonyl)aMinopiperidine

4-(Boc-amino)piperidine,96%

Carbamic acid, N-4-piperidinyl-, 1,1-dimethylethyl ester

4-(N-Boc-amino)piperidine 96%

N-(4-piperidinyl)carbamic acid tert-butyl ester

N-(4-piperidyl)carbamic acid tert-butyl ester

1,1-Dimethylethyl (4-piperidinyl)carbamate

4-((1-tert-Butoxycarbonyl)amino)piperidine

Carbamic acid, 4-piperidinyl-, 1,1-dimethylethyl ester (9CI)

4-T-Boc-Amino Piperidine

4-N-BOC-AMINO-PIPERIDINE (OR) 4(TERT BOC)-AMINO PIPERIDINE (GROUP-B, SRL NO:1124)

tert-Butyl 4-piperidinylcarbamate

4-Tert-Boc-AminoPiperdine

4-Tert-Boc-Amino-Piperidine

TERT-BUTYL PIPERIDIN-4-YLCARBAMATE

PIPERIDIN-4-YL-CARBAMIC ACID TERT-BUTYL ESTER

4-N-1-BOC-AMINOPIPERIDINE

BOC (PROTECTED)-4-AMINO PIPERIDINE

4-BOC-AMINO PIPERIDINE,98%

4-BOC-AMINO PIPERDINE

tert-butyl N-(4-piperidinyl)carbamate

4-N-BOC-Aminopiperidine,98%

tert-Butyl N-(4-piperidyl)carbaMate

tert-butyl 1-aMinopiperidine-4-carboxylate

4-N-BOC-AMinopiperidine, 98% 5GR

4-N-BOC-AMinopiperid

4-(<i>tert</i>-ButoxycarbonylaMino)piperidine

piperidin-4-yl-carbaMic acid tert-butyl ester hydrochloride

tert-Butyl (piperidin-4-yl)carbamate, 4-[(tert-Butoxycarbonyl)amino]piperidine

tert-butyl N-(piperidin-4-yl)carbaMate

4-Aminopiperidine, 4-BOC protected 97%

4-N-BOC-Aminopiperidine CAS:73874-95-0

4-(tert-Butoxycarbonylamino)piperidine &gt

4-(N-BOC-AMINO)PIPERIDINE High Purity

4-N-Boc-Aminopperidine

4-N-BOC-Aminopiperidine ISO 9001：2015 REACH

4-N-BOC-AMINO-PIPERIDINE (OR) 4(TER T BOC)-AMINO PIPERIDINE

N-BOC-4-Aminopiperidine pure, 97%

4-N-B0C- Aminopiperidine

Prucapride 11

Prucalopride Impurity 46

4-(<i>N</i>-Boc-amino)piperidine

4-(N-Boc-amino)piperidine, 96%

73874-95-0

C10H21N2O2

Heterocyclic Building Blocks

Piperidines