tert-butyl thiazol-4-ylcarbamate
Uses- Product Name
- tert-butyl thiazol-4-ylcarbamate
- CAS No.
- 1235406-42-4
- Chemical Name
- tert-butyl thiazol-4-ylcarbamate
- Synonyms
- 100682;4-(BOC-AMINO)-THIAZOLE;TERT-BUTYL(1,3-THIAZOL-4-YL);tert-butyl thiazol-4-ylcarbamate;tert-butyl (1,3-thiazol-4-yl)carbamate;tert-Butyl N-(1,3-thiazol-4-yl)carbaMate;(1,3-Thiazol-4-yl)carbamic acid tert-butyl ester;CarbaMic acid, N-4-thiazolyl-, 1,1-diMethylethyl ester
- CBNumber
- CB22123954
- Molecular Formula
- C8H12N2O2S
- Formula Weight
- 200.26
- MOL File
- 1235406-42-4.mol
tert-butyl thiazol-4-ylcarbamate Property
- Melting point:
- 153-155 °C
- Boiling point:
- 254.9±13.0 °C(Predicted)
- Density
- 1.242±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 12.39±0.70(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B740023
- Product name
- tert-ButylThiazol-4-ylcarbamate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- AS16025
- Product name
- 4-(Boc-amino)thiazole
- Purity
- 97+%
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- T14079
- Product name
- tert-ButylN-(1,3-thiazol-4-yl)carbamate
- Packaging
- 500mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- T14079
- Product name
- tert-ButylN-(1,3-thiazol-4-yl)carbamate
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 076393
- Product name
- tert-Butyl thiazol-4-ylcarbamate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $231
- Updated
- 2021/12/16
tert-butyl thiazol-4-ylcarbamate Chemical Properties,Usage,Production
Uses
tert-butyl thiazol-4-ylcarbamate is an organic intermediate that can be prepared from thiazole-4-carboxylic acid via the Curtiss rearrangement reaction.
Synthesis
3973-08-8
75-65-0
1235406-42-4
Under nitrogen protection, 5.80 mL (41.84 mmol) of triethylamine and 9.10 mL (42.19 mmol) of azido azide phosphate were sequentially added to a solution of 4.85 g (37.55 mmol) of thiazole-4-carboxylic acid dissolved in 180 mL of tert-butanol and the reaction mixture was cooled in an ice bath. Subsequently, the reaction system was heated to reflux for 16 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in dichloromethane and washed twice sequentially with water and saturated sodium chloride solution. The organic phase was dried over anhydrous sodium sulfate and concentrated. The resulting crude product was purified by silica gel column chromatography (eluent: cyclohexane/ethyl acetate, 1:1, v/v) to afford 7.07 g (35.30 mmol, 94% yield) of N-Boc-4-aminothiazole as beige crystals.ESI-MS: m/e 201 ([M + H]+).
References
[1] Synthesis, 2010, # 18, p. 3152 - 3162
[2] Patent: US2012/252759, 2012, A1. Location in patent: Page/Page column 22
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 16, p. 7029 - 7042
[4] Patent: WO2014/41175, 2014, A1. Location in patent: Page/Page column 57
[5] Patent: EP3375782, 2018, A1. Location in patent: Paragraph 0049; 0152; 0154
tert-butyl thiazol-4-ylcarbamate Preparation Products And Raw materials
Raw materials
Preparation Products
tert-butyl thiazol-4-ylcarbamate Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 025-86918202 4000255188
- Fax
- 86-025-86918232
- sales@pharmablock.com
- Country
- China
- ProdList
- 5000
- Advantage
- 55
- Tel
- 21-57721279
- Fax
- QQ：14057904
- sales@shydchem.com.cn
- Country
- China
- ProdList
- 998
- Advantage
- 56
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- 021-53292253
- Fax
- 021-53292253
- biz@synches.com
- Country
- China
- ProdList
- 199
- Advantage
- 64
- Tel
- 0555-8228058 13621628489
- Fax
- 0512-63261912
- sales1@stepuppharm.com
- Country
- China
- ProdList
- 259
- Advantage
- 55
- Tel
- 028-85114309 18982182443
- yangli@happysyn.com
- Country
- China
- ProdList
- 2150
- Advantage
- 55
- Tel
- 18030648795
- Fax
- 028-61777050
- sales@cdforestchem.com
- Country
- China
- ProdList
- 1998
- Advantage
- 58
View Lastest Price from tert-butyl thiazol-4-ylcarbamate manufacturers
- Product
- tert-butyl thiazol-4-ylcarbamate 1235406-42-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2019-12-30