ChemicalBook > CAS DataBase List > 4-N-BOC-Aminopiperidine

4-N-BOC-Aminopiperidine

Description

Product Name: 4-N-BOC-Aminopiperidine
CAS No.: 73874-95-0
Chemical Name: 4-N-BOC-Aminopiperidine
Synonyms: TERT-BUTYL PIPERIDIN-4-YLCARBAMATE;tert-Butyl N-(4-piperidyl)carbaMate;tert-butyl N-(piperidin-4-yl)carbaMate;PIPERIDIN-4-YL-CARBAMIC ACID TERT-BUTYL ESTER;4-BOC-AMINOPIPERIDINE;4-(N-BOC-AMINO)PIPERIDINE;Prucapride 11;BUTTPARK 90\06-01;4-N-BOC-AMinopiperid;BOC-4-AMINOPIPERIDINE
CBNumber: CB9192199
Molecular Formula: C10H20N2O2
Formula Weight: 200.28
MOL File: 73874-95-0.mol

Less

4-N-BOC-Aminopiperidine Property

Melting point:: 162-166 °C(lit.)
Boiling point:: 80°C/0.05mm
Density: 1.02±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
pka: 12.39±0.20(Predicted)
form: Crystalline Powder
color: Off-white
Sensitive: Air Sensitive
InChI: InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-8-4-6-11-7-5-8/h8,11H,4-7H2,1-3H3,(H,12,13)
InChIKey: CKXZPVPIDOJLLM-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NC1CCNCC1
CAS DataBase Reference: 73874-95-0(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 540935
Product name: 4-(N-Boc-amino)piperidine
Purity: 96%
Packaging: 1g
Price: $22.24
Updated: 2025/07/31

Sigma-Aldrich

Product number: 540935
Product name: 4-(N-Boc-amino)piperidine
Purity: 96%
Packaging: 5g
Price: $34.3
Updated: 2025/07/31

TCI Chemical

Product number: B2319
Product name: 4-(tert-Butoxycarbonylamino)piperidine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $17
Updated: 2025/07/31

TCI Chemical

Product number: B2319
Product name: 4-(tert-Butoxycarbonylamino)piperidine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $30
Updated: 2025/07/31

Cayman Chemical

Product number: 30398
Product name: 4-(N-Boc-amino)piperidine
Packaging: 1g
Price: $37
Updated: 2024/03/01

Less

4-N-BOC-Aminopiperidine Chemical Properties,Usage,Production

Description

4-(N-Boc-amino)piperidone may be used as a functionalization reagent for introduction of a primary and a tertiary amino group to poly(2-isopropyl-2-oxazoline. It can also be used as pharma building block. It is used in the synthesis of a piperidine-4-carboxamide CCR5 antagonist with potent anti-HIV 1-activity. It is an intermediate for the synthesis of various pharmaceutical and biologically active compounds, including inhibitors and therapeutic agents. It is used for the synthesis of diphenyl purine derivatives as peripherally selective cannabinoid receptor 1 Antagonists.

Chemical Properties

off-white crystalline powder

Uses

Pharma building block.

General Description

4-(N-Boc-amino)piperidone is a piperidone derivative.

Synthesis

73889-19-7

73874-95-0

General procedure for the synthesis of 4-tert-butoxycarbonylaminopiperidine from tert-butyl (1-benzylpiperidin-4-yl)carbamate: N-butyl-1-benzylpiperidin-4-ylcarbamate (3.80 g, 13.1 mmol) was dissolved in 26 mL of methanol in a 100 mL reaction vessel. A catalytic amount of 10% palladium/carbon (Pd/C) was added. The reaction was stirred under hydrogen atmosphere for 12 hours. Upon completion of the reaction, the palladium/carbon catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure to remove the solvent. The resulting residue was purified by silica gel column chromatography to afford 4-tert-butoxycarbonylaminopiperidine (2.64 g, 99% yield). The product was confirmed by 1H-NMR (200 MHz, CD3OD): δ 1.36 (s, 9H), 1.84-2.36 (m, 4H), 2.74 (m, 2H), 3.42 (m, 2H), 3.60 (br, 1H).LC/MS analysis showed the [M+H]+ peak as 201.

References

[1] Patent: WO2008/54154, 2008, A1. Location in patent: Page/Page column 33; 34; 76; 77; 162-164
[2] Patent: WO2007/52938, 2007, A1. Location in patent: Page/Page column 18
[3] Journal of Medicinal Chemistry, 1999, vol. 42, # 14, p. 2706 - 2715
[4] Patent: WO2007/46550, 2007, A1. Location in patent: Page/Page column 117
[5] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 24, p. 5345 - 5352

4-N-BOC-Aminopiperidine Preparation Products And Raw materials

Raw materials

1,1'-Carbonyldiimidazole Hydrazinium hydroxide solution Acetone Di-tert-butyl dicarbonate Potassium carbonate 2,3-DICHLORO-5,8-DIHYDROXY-1,4-NAPHTHOQUINONE Chloroform Palladium Sodium nitrite Methyl isonipecotate Benzyl bromide Ethyl acetate Hydrochloric acid Isonipecotic acid Bromine Acetic acid Methanol

Preparation Products

Less

4-N-BOC-Aminopiperidine Suppliers

Americas 1 Belgium 2 Canada 1 China 359 Europe 4 France 3 Germany 10 India 45 Japan 4 Slovakia 1 South Korea 1 Sweden 1 Switzerland 3 Ukraine 2 United Kingdom 16 United States 77 Global 530

Sichuan Argalbio Technology Co,.Ltd

Tel: 028-028-60651388 13330964498
Email: slyu@hengkangtech.com
Country: China
ProdList: 378
Advantage: 58

Shanghai Hobor Chemical Co., Ltd

Tel: 021-57790084; 13918007836
Fax: 021-51685238
Email: sales@hoborchem.com
Country: China
ProdList: 392
Advantage: 60

Shanghai Troedsson Technology Co., LTD

Tel: 18117455885
Email: qihongchem@163.com
Country: China
ProdList: 9092
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: sales@jonln.com
Country: China
ProdList: 1995
Advantage: 65

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
Fax: +86 351 7031519
Email: sales@RHFChem.com
Country: China
ProdList: 2338
Advantage: 56

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Shijiazhuang Sdyano Fine Chemical Co., Ltd.

Tel: 0311-89250318 031166536426
Fax: 4000311741
Email: master@sjzsdyn.com
Country: China
ProdList: 2806
Advantage: 65

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Sichuan Guanghan Bio-Tech Co., Ltd

Tel: +86-28-86127071
Fax: +86-28-86127072
Email: info@sino-produce.com
Country: China
ProdList: 406
Advantage: 66

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Boc Chemical Co.,Ltd

Tel: 021-34975603-808 18721111801
Fax: +86-21-34975602-805
Email: sales@bocpharma.com
Country: China
ProdList: 1009
Advantage: 64

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16075
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Shanghai Chem-Milestone Co., Ltd

Tel: 021-50273253 13641951838
Fax: +86-21-61294436
Email: chemmilestone@163.com
Country: China
ProdList: 151
Advantage: 62

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 7247
Advantage: 62

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Fax: 021-5649-1756
Email: 2819742715@qq.com
Country: China
ProdList: 4000
Advantage: 55

Jinan Bond Chemical Technology Co., Ltd.

Tel: 86-531-88280989
Fax: 86-531-88280989
Email: mymail1996@126.com
Country: China
ProdList: 256
Advantage: 55

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-4000505016 13380397412
Fax: 0755 28094224
Email: 3001272453@qq.com
Country: China
ProdList: 5158
Advantage: 50

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Suzhou Sibian Chemical Technology Co.,Ltd.

Tel: 0512-65617459 18915409046
Fax: 0512-65617459
Email: sales@sibian-chem.com
Country: China
ProdList: 1922
Advantage: 55

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Beijing innoChem Science & Technology Co.,Ltd.

Tel: 400-810-7969 010-59572699
Fax: 010-59572688
Email: ningzi.li@inno-chem.com.cn
Country: China
ProdList: 6134
Advantage: 55

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.

Tel: 21-33585366 13311639313
Fax: +86-21-34979012
Email: sales@shyrchem.com
Country: China
ProdList: 806
Advantage: 55

SuZhou ShiYa Biopharmaceuticals, Inc.

Tel: 86(512)5235 8471 17715136450
Fax: 86(512)5235 6881
Email: sales@shiyabiopharm.com
Country: China
ProdList: 4169
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9546
Advantage: 55

Cantotech Chemicals, Ltd.

Tel: 86-0755-86635001
Fax: 86-0755-22642228
Email: cantotech@126.com
Country: China
ProdList: 4566
Advantage: 55

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

Less

View Lastest Price from 4-N-BOC-Aminopiperidine manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: 4-Boc-aminopiperidine 73874-95-0
Price: US $1.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99.5% HPLC
Supply Ability: 500KG/MONTH
Release date: 2021-05-25

Anhui Yiao New Material Technology Co., Ltd

Product: 4-N-(tert-Butoxycarbonyl)aminopiperidine 73874-95-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1 ton
Release date: 2023-11-02

Anhui Yiao New Material Technology Co., Ltd

Product: 4-N-(tert-Butoxycarbonyl)aminopiperidine 73874-95-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1 ton
Release date: 2023-11-02

73874-95-0, 4-N-BOC-AminopiperidineRelated Search:

1-Aminopiperidine DROPERIDOL Haloperidol 3-N-Boc-aminopiperidine tert-butyl thiazol-4-ylcarbamate (1R,4R)-(4-MethylaMino-cyclohexyl)-carbaMic acid tert-butyl ester 1-Oxa-6-azaspiro[3.3]heptane-6-carboxylic acid, 3,3-diMethyl-, 1,1-diMethylethyl ester tert-butyl((5-carbamoyl-1-methyl-1H-pyrazol-3-yl)methyl)(methyl)carbamate DI-TERT-BUTYL ETHER Carbamic acid, N-methyl-N-[(3-nitrophenyl)methyl]-, 1,1-dimethylethyl ester 4-AMINO-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID 4-TERT-BUTOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONOBENZYL ESTER 4-N-Boc-4-N-Methyl-aminopiperidine 1-BENZYL-4-(N-BOC-AMINO) PIPERIDINE 98 4-TERT-BUTOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER Diphenoxylate (R)-3-(Boc-Amino)piperidine (R)-1-Benzyl-3-N-Boc-aminopiperidine

4-(TERT-BUTOXYCARBONYLAMINO)PIPERIDINE

4-N-TERT-BOC-AMINO PIPERIDINE

4-N-(TERT-BUTOXYCARBONYL)AMINOPIPERIDINE

4-BOC-AMINOPIPERIDINE

4-AMINOPIPERIDINE, 4-BOC PROTECTED

4-(N-BOC-AMINO)PIPERIDINE

4-(tert-ButoxycarbonylaMino)piperidine, 98.0%(GC&T

CARBAMIC ACID, 4-PIPERIDINYL-, 1,1-DIMETHYLETHYL ESTER

BUTTPARK 90\06-01

BOC-4-AMINOPIPERIDINE

4 - bok - aMino piperidine

4-N-BOC-AMinopiperidine SynonyMs 4-N-(tert-Butoxycarbonyl)aMinopiperidine

4-(Boc-amino)piperidine,96%

Carbamic acid, N-4-piperidinyl-, 1,1-dimethylethyl ester

4-(N-Boc-amino)piperidine 96%

N-(4-piperidinyl)carbamic acid tert-butyl ester

N-(4-piperidyl)carbamic acid tert-butyl ester

1,1-Dimethylethyl (4-piperidinyl)carbamate

4-((1-tert-Butoxycarbonyl)amino)piperidine

Carbamic acid, 4-piperidinyl-, 1,1-dimethylethyl ester (9CI)

4-T-Boc-Amino Piperidine

4-N-BOC-AMINO-PIPERIDINE (OR) 4(TERT BOC)-AMINO PIPERIDINE (GROUP-B, SRL NO:1124)

tert-Butyl 4-piperidinylcarbamate

4-Tert-Boc-AminoPiperdine

4-Tert-Boc-Amino-Piperidine

TERT-BUTYL PIPERIDIN-4-YLCARBAMATE

PIPERIDIN-4-YL-CARBAMIC ACID TERT-BUTYL ESTER

4-N-1-BOC-AMINOPIPERIDINE

BOC (PROTECTED)-4-AMINO PIPERIDINE

4-BOC-AMINO PIPERIDINE,98%

4-BOC-AMINO PIPERDINE

tert-butyl N-(4-piperidinyl)carbamate

4-N-BOC-Aminopiperidine,98%

tert-Butyl N-(4-piperidyl)carbaMate

tert-butyl 1-aMinopiperidine-4-carboxylate

4-N-BOC-AMinopiperidine, 98% 5GR

4-N-BOC-AMinopiperid

4-(<i>tert</i>-ButoxycarbonylaMino)piperidine

piperidin-4-yl-carbaMic acid tert-butyl ester hydrochloride

tert-Butyl (piperidin-4-yl)carbamate, 4-[(tert-Butoxycarbonyl)amino]piperidine

tert-butyl N-(piperidin-4-yl)carbaMate

4-Aminopiperidine, 4-BOC protected 97%

4-N-BOC-Aminopiperidine CAS:73874-95-0

4-(tert-Butoxycarbonylamino)piperidine &gt

4-(N-BOC-AMINO)PIPERIDINE High Purity

4-N-Boc-Aminopperidine

4-N-BOC-Aminopiperidine ISO 9001：2015 REACH

4-N-BOC-AMINO-PIPERIDINE (OR) 4(TER T BOC)-AMINO PIPERIDINE

N-BOC-4-Aminopiperidine pure, 97%

4-N-B0C- Aminopiperidine

Prucapride 11

Prucalopride Impurity 46

4-(<i>N</i>-Boc-amino)piperidine

4-(N-Boc-amino)piperidine, 96%

73874-95-0

C10H21N2O2

Heterocyclic Building Blocks

Piperidines