(R)-1-N-BOC-3-CYANO-PIPERIDINE

Product Name: (R)-1-N-BOC-3-CYANO-PIPERIDINE
CAS No.: 915226-44-7
Chemical Name: (R)-1-N-BOC-3-CYANO-PIPERIDINE
Synonyms: 1-N-Boc-3-(R)-cyanopiperidine;(R)-1-N-BOC-3-3-cyano-piperidine;(R)-tert-Butyl 3-cyanopiperidine;tert-butyl (3R)-3-cyanopiperidine-1-carboxylate;(R)-tert-butyl 3-cyanopiperidine 2-Cyanopiperidine;(R)-3-Cyanopiperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 3-cyano-, 1,1-dimethylethyl ester, (3R)-
CBNumber: CB11119274
Molecular Formula: C11H18N2O2
Formula Weight: 210.27
MOL File: 915226-44-7.mol

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(R)-1-N-BOC-3-CYANO-PIPERIDINE Property

Boiling point:: 325.3±35.0 °C(Predicted)
Density: 1.07±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -3.42±0.40(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B814638
Product name: (R)-tert-Butyl3-cyanopiperidine-1-carboxylate
Packaging: 500mg
Price: $330
Updated: 2021/12/16

AK Scientific

Product number: 5387AC
Product name: 1-N-Boc-3-(R)-Cyanopiperidine
Packaging: 1g
Price: $345
Updated: 2021/12/16

Matrix Scientific

Product number: 131780
Product name: (R)-tert-Butyl3-cyanopiperidine-1-carboxylate
Purity: 97%
Packaging: 1g
Price: $478
Updated: 2021/12/16

Activate Scientific

Product number: AS100331
Product name: (R)-1-Boc-3-cyanopiperidine
Purity: 95% ee
Packaging: 5G
Price: $916
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0015859
Product name: (R)-3-CYANO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 1G
Price: $928.97
Updated: 2021/12/16

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(R)-1-N-BOC-3-CYANO-PIPERIDINE Chemical Properties,Usage,Production

Synthesis

915226-43-6

915226-44-7

General procedure for the synthesis of tert-butyl (R)-3-cyanopiperidine-1-carboxylate from tert-butyl (R)-3-carbamoylpiperidine-1-carboxylate: under nitrogen protection, phosphorochloride (203 μL, 2.18 mmol) was slowly added dropwise to a solution of tert-butyl (R)-3-carbamoylpiperidine-1-carboxylate (0.5 g, 2.18 mmol) in pyridine (10 mL) in pyridine (10 mL) at a reaction temperature of 0 °C. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, it was diluted with ethyl acetate and washed twice with 10% hydrochloric acid solution. The organic and aqueous phases were separated and the organic phase was dried over anhydrous sodium sulfate and subsequently concentrated to dryness under reduced pressure. The resulting tert-butyl (R)-3-cyanopiperidine-1-carboxylate did not require further purification and could be used directly in the next step of the reaction. Yield: quantitative; LCMS (T): 4.48 min (Method A); MS (ES+) m/z: 211.1.

References

[1] Patent: US2009/215822, 2009, A1. Location in patent: Page/Page column 10

(R)-1-N-BOC-3-CYANO-PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-1-N-BOC-3-CYANO-PIPERIDINE Suppliers

China 52 India 2 Switzerland 1 United Kingdom 1 United States 7 Global 63

J & K SCIENTIFIC LTD.

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View Lastest Price from (R)-1-N-BOC-3-CYANO-PIPERIDINE manufacturers

Career Henan Chemical Co

Product: tert-butyl (3R)-3-cyanopiperidine-1-carboxylate 915226-44-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-02-05

915226-44-7, (R)-1-N-BOC-3-CYANO-PIPERIDINE Related Search:

(R)-1-(TERT-BUTOXYCARBONYL)-3-PIPERIDINECARBOXALDEHYDE (R)-1-BOC-3-PROPYLPIPERAZINE (R)-1-Boc- 3-ethyl-piperazine TERT-BUTYL N-(2-CYANOETHYL)CARBAMATE 3-(N-BOC-METHYLAMINO)PROPIONITRILE (2-Cyanoethyl)ethyl-carbaMic Acid tert-Butyl Ester 1-METHYL-PIPERIDINE-3-CARBONITRILE 3-PIPERIDINECARBONITRILE N-Boc-3-Cyanopiperidine (R)-1-N-BOC-3-CYANO-PIPERIDINE

1-Piperidinecarboxylic acid, 3-cyano-, 1,1-dimethylethyl ester, (3R)-

1-N-Boc-3-(R)-cyanopiperidine

(R)-3-Cyanopiperidine-1-carboxylic acid tert-butyl ester

(R)-tert-butyl 3-cyanopiperidine 2-Cyanopiperidine

tert-butyl (3R)-3-cyanopiperidine-1-carboxylate

(R)-tert-Butyl 3-cyanopiperidine

(R)-1-N-BOC-3-3-cyano-piperidine

915226-44-7