(R)-1-N-BOC-3-CYANO-PIPERIDINE
- Product Name
- (R)-1-N-BOC-3-CYANO-PIPERIDINE
- CAS No.
- 915226-44-7
- Chemical Name
- (R)-1-N-BOC-3-CYANO-PIPERIDINE
- Synonyms
- 1-N-Boc-3-(R)-cyanopiperidine;(R)-1-N-BOC-3-3-cyano-piperidine;(R)-tert-Butyl 3-cyanopiperidine;tert-butyl (3R)-3-cyanopiperidine-1-carboxylate;(R)-tert-butyl 3-cyanopiperidine 2-Cyanopiperidine;(R)-3-Cyanopiperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 3-cyano-, 1,1-dimethylethyl ester, (3R)-
- CBNumber
- CB11119274
- Molecular Formula
- C11H18N2O2
- Formula Weight
- 210.27
- MOL File
- 915226-44-7.mol
(R)-1-N-BOC-3-CYANO-PIPERIDINE Property
- Boiling point:
- 325.3±35.0 °C(Predicted)
- Density
- 1.07±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -3.42±0.40(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B814638
- Product name
- (R)-tert-Butyl3-cyanopiperidine-1-carboxylate
- Packaging
- 500mg
- Price
- $330
- Updated
- 2021/12/16
- Product number
- 5387AC
- Product name
- 1-N-Boc-3-(R)-Cyanopiperidine
- Packaging
- 1g
- Price
- $345
- Updated
- 2021/12/16
- Product number
- 131780
- Product name
- (R)-tert-Butyl3-cyanopiperidine-1-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $478
- Updated
- 2021/12/16
- Product number
- AS100331
- Product name
- (R)-1-Boc-3-cyanopiperidine
- Purity
- 95% ee
- Packaging
- 5G
- Price
- $916
- Updated
- 2021/12/16
- Product number
- CHM0015859
- Product name
- (R)-3-CYANO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $928.97
- Updated
- 2021/12/16
(R)-1-N-BOC-3-CYANO-PIPERIDINE Chemical Properties,Usage,Production
Synthesis
915226-43-6
915226-44-7
General procedure for the synthesis of tert-butyl (R)-3-cyanopiperidine-1-carboxylate from tert-butyl (R)-3-carbamoylpiperidine-1-carboxylate: under nitrogen protection, phosphorochloride (203 μL, 2.18 mmol) was slowly added dropwise to a solution of tert-butyl (R)-3-carbamoylpiperidine-1-carboxylate (0.5 g, 2.18 mmol) in pyridine (10 mL) in pyridine (10 mL) at a reaction temperature of 0 °C. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, it was diluted with ethyl acetate and washed twice with 10% hydrochloric acid solution. The organic and aqueous phases were separated and the organic phase was dried over anhydrous sodium sulfate and subsequently concentrated to dryness under reduced pressure. The resulting tert-butyl (R)-3-cyanopiperidine-1-carboxylate did not require further purification and could be used directly in the next step of the reaction. Yield: quantitative; LCMS (T): 4.48 min (Method A); MS (ES+) m/z: 211.1.
References
[1] Patent: US2009/215822, 2009, A1. Location in patent: Page/Page column 10
(R)-1-N-BOC-3-CYANO-PIPERIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-1-N-BOC-3-CYANO-PIPERIDINE Suppliers
- Tel
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- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
- Tel
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- Fax
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- enquiry@sldrugs.com
- Country
- India
- ProdList
- 2683
- Advantage
- 50
View Lastest Price from (R)-1-N-BOC-3-CYANO-PIPERIDINE manufacturers
- Product
- tert-butyl (3R)-3-cyanopiperidine-1-carboxylate 915226-44-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-02-05