(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine

Product Name: (S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine
CAS No.: 147081-44-5
Chemical Name: (S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine
Synonyms: tert-butyl (S)-3-aminopyrrolidine-1-carboxylate;(S)-(-)-1-BOC-3-AMINOPYRROLIDINE;(S)-TERT-BUTYL 3-AMINOPYRROLIDINE-1-CARBOXYLATE;(S)-1-BOC-3-AMINOPYRROLIDINE;tert-Butyl (3S)-3-aminopyrrolidine-1-carboxylate;(3S)-3-aminopyrroL;(S)-3-Amino-n-boc-pyrr;(S)-3-Amino-1-Boc-pyrroli...;(s)-n-boc-3-aminopyrrolidine;(S)-3-AMINO-N-BOC-PYRROLIDINE
CBNumber: CB7853113
Molecular Formula: C9H18N2O2
Formula Weight: 186.25
MOL File: 147081-44-5.mol

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(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine Property

alpha: -2 º (c=1, chloroform)
Boiling point:: 216-217 °C(lit.)
Density: 1.067 g/mL at 25 °C(lit.)
refractive index: n20/D 1.4720(lit.)
Flash point:: 196 °F
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
form: Liquid
pka: 9.55±0.20(Predicted)
color: Clear colorless to yellow
optical activity: [α]20/D 2°, c = 1 in chloroform
Sensitive: Air Sensitive
BRN: 8312125
InChI: InChI=1S/C9H18N2O2/c1-9(2,3)13-8(12)11-5-4-7(10)6-11/h7H,4-6,10H2,1-3H3/t7-/m0/s1
InChIKey: CMIBWIAICVBURI-ZETCQYMHSA-N
SMILES: N1(C(OC(C)(C)C)=O)CC[C@H](N)C1
CAS DataBase Reference: 147081-44-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,C,Xi
Risk Statements: 22-41
Safety Statements: 26
RIDADR: UN 2810 6.1/PG 3
WGK Germany: 2
HazardClass: 8
PackingGroup: III
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 634794
Product name: (S)-(?)-1-Boc-3-aminopyrrolidine
Purity: 95%
Packaging: 1g
Price: $54.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 634794
Product name: (S)-(?)-1-Boc-3-aminopyrrolidine
Purity: 95%
Packaging: 5g
Price: $161
Updated: 2025/07/31

TCI Chemical

Product number: B2921
Product name: (3S)-(-)-1-(tert-Butoxycarbonyl)-3-aminopyrrolidine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $63
Updated: 2025/07/31

TCI Chemical

Product number: B2921
Product name: (3S)-(-)-1-(tert-Butoxycarbonyl)-3-aminopyrrolidine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $187
Updated: 2025/07/31

TRC

Product number: B810580
Product name: (S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine
Packaging: 50mg
Price: $60
Updated: 2021/12/16

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(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liqui

Uses

(S)-(-)-1-Boc-3-aminopyrrolidine may be used to prepare:

Descarboxamide analog of 4-N-(N^ω-nitro-L-argininyl)-trans-4-amino-L-proline amide.
Histamine 3 (H₃) receptor antagonists containing pyrrolidin-3-yl-N-methylbenzamide moiety.

Synthesis

125552-56-9

147081-44-5

To a solution of compound 178 (2.0 g, 9.42 mmol, 1.0 eq.) in methanol (40 mL) was added palladium carbon (1.0 g, 0.94 mmol, 0.1 eq.). The reaction mixture was subjected to hydrogenation at atmospheric pressure and room temperature for 6 hours. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure. The target compound (S)-1-Boc-3-aminopyrrolidine was obtained as a yellow oil (1.7 g, 97% yield).

References

[1] Patent: US2009/221565, 2009, A1. Location in patent: Page/Page column 51
[2] Patent: WO2016/34134, 2016, A1. Location in patent: Paragraph 00470
[3] Patent: CN105399698, 2016, A. Location in patent: Paragraph 1340-1342
[4] Patent: WO2005/811, 2005, A1. Location in patent: Page/Page column 61
[5] Patent: WO2005/20975, 2005, A2. Location in patent: Page/Page column 221

(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Di-tert-butyl dicarbonate Sodium hydroxide Isopropyl alcohol 1-Butanol (3S)-(+)-3-Aminopyrrolidine dihydrochloride

Preparation Products

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(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine Suppliers

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View Lastest Price from (S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: (S)-1-Boc-3-Aminopyrrolidine 147081-44-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-11-27

Hebei Chuanghai Biotechnology Co., Ltd

Product: (S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine 147081-44-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-31

Hebei Yanxi Chemical Co., Ltd.

Product: (S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine 147081-44-5
Price: US $20.00-1.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-11-02

147081-44-5, (S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidineRelated Search:

(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine (2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate (2S,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate hydrochloride N-Boc-cis-4-Fmoc-Amino-L-proline (3R,4R)-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate (1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE (2S,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate (3r)-(+)-1-(tert-butoxycarbonyl)-3-aminopyrrolidine,(R)-(+)-N-tert-Butoxycarbonyl-3-aminopyrrolidine 1-TERT-BUTOXYCARBONYL-3-AMINOPYRROLIDINE (S)-3-Aminopyrrolidine 3-Aminopyrrolidine trans-3-Amino-4-(4-methylphenyl)pyrrolidine, N-BOC protected (S)-(+)-N-BOC-3-N-FMOC-AMINOPYRROLIDINE& 3-AMINO-4-PHENYLPYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (S)-1-BOC-3-N-(PYRIDIN-4-YLMETHYL)-AMINO-PYRROLIDINE (S)-(+)-N-BOC-4-AMINO-L-PROLINE, 97 (2S,4S)-BOC-4-(BOC-AMINO)-PROLINE (2S,4S)-1-BOC-2-HYDROXYMETHYL-4-AMINO PYRROLIDINE-HCL

(s)-n-boc-3-aminopyrrolidine

tert-Butyl (3S)-3-aminopyrrolidine-1-carboxylate

tert-Butyl (3S)-3-aminopyrrolidine-1-carboxylate, (3S)-3-Amino-1-(tert-butoxycarbonyl)pyrolidine

1-t-butoxycarbonyl-3-S-aMinopyrrolidine

(3S)-(-)-1-Boc-3-aminopyrrolidine (3S)-(-)-3-Amino-1-(tert-butoxycarbonyl)pyrrolidine (3S)-(-)-3-Amino-1-Boc-pyrrolidine

(S)-3-Amino-n-boc-pyrr

(S)-3-Amino-1-Boc-pyrroli...

(3S)-3-Aminopyrrolidine, N1-BOC protected

(S)-(-)-1-Boc-3-aMinopyrrolidine, 97+%

(S)-(-)-1-Boc-3-aminopyrrolidine 95%

tert-butyl (S)-3-aminopyrrolidine-1-carboxylate

(S)-N-Boc-3-aminopyrrolidine,98%e.e.

1-PYRROLIDINECARBOXYLIC ACID, 3-AMINO-, 1,1-DIMETHYLETHYL ESTER, (3S)-

(S)-(-)-1-BOC-3-AMINOPYRROLIDINE

(S)-1-BOC-3-AMINOPYRROLIDINE

(S)-(-)-1-TBOC-3-AMINOPYRROLIDINE

(s)-(-)-1-tert-butoxycarbonyl-3-aminopyrrolidine

(S)-3-AMINO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

(S)-3-AMINO-N-BOC-PYRROLIDINE

(S)-3-AMINO-1-TERT-BUTOXYCARBONYLPYRROLIDINE

(S)-3-AMINO-1-N-(T-BUTOXYCARBONYL)PYRROLIDINE

(S)-3-AMINO-1-N-BOC-PYRROLIDINE

(S)-3-AMINO-1-N-BOC-PYRROLIDINE CITRIC ACID SALT

(S)-3-AMINO-1-BOC-PYRROLIDINE

(S)-TERT-BUTYL 3-AMINOPYRROLIDINE-1-CARBOXYLATE

S-1-N-BOC-3-AMINO PYRROLIDINE

(3s)-(-)-1-(tert-butoxycarbonyl)-3-aminopyrrolidine

(3s)-(-)-1-boc-3-aminopyrrolidine

(3s)-(-)-3-amino-1-boc-pyrrolidine

(s)-n-boc-3-aminopyrrolidine(S)-1-Boc-3-Aminopyrrolidine

(S)-(-)-BOC-3-AMINOPYRROLIDINE

(S)-(-)-1-BOC-3-AMINOPYRROLIDINE 95% EE 97%

(S)-(-)-1-Boc-3-aminopyrrolidine, 98%, ee 99%

(3S)-3-Amino-1-(tert-butoxycarbonyl)pyrrolidine

(S)-3-Aminopyrrolidine, N1-BOC protected

(3S)-(-)-1-(tert-Butoxycarbonyl)-3-aminopyrrolidine &gt

(3S)-3-aminopyrroL

(<i>S</i>)-(?)-1-Boc-3-aminopyrrolidine

(3S)-(-)-1-(tert-Butoxycarbonyl)-3-aminopyrrolidine 97%

(S)-1-tert-Butyloxycarbonyl-3-aminopyrrolidine

147081-44-5

Heterocyclic Building Blocks

Pyrrolidines

Asymmetric Synthesis

Chiral Building Blocks

Heterocyclic Building Blocks

Pyrrolidines

Benzenes

3-Aminopyrrolidines

Chiral 3-Aminopyrrolidines

pharmacetical

chiral

Pyrrole&Pyrrolidine&Pyrroline