(2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate

Product Name: (2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate
CAS No.: 254881-77-1
Chemical Name: (2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate
Synonyms: (4S)-4-Amino-1-Boc-D-proline methyl ester;(2R,4S)-N-Boc-4-amino-D-proline methyl ester;Methyl (2R,4S)-4-AMino-1-Boc-2-pyrrolidinecarboxylate;Methyl (2R,4S)-4-AMino-1-Boc-2-pyrrolidinedicarboxylate;Methyl (2R,4S)-4-aminopyrrolidine-2-carboxylate, N1-BOC protected;1-tert-Butyl 2-methyl (2R,4S)-4-aminopyrrolidine-1,2-dicarboxylate;(2r,4s)-1-tert-butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate;(2R,4S)-4-AMINO-1-BOC-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER-HCl;1-(tert-Butyl) 2-methyl (2R,4S)-4-amino-1,2-pyrrolidinedicarboxylate;Methyl (2R,4S)-1-(tert-butoxycarbonyl)-4-aMinopyrrolidine-2-carboxylate
CBNumber: CB31267586
Molecular Formula: C11H20N2O4
Formula Weight: 244.29
MOL File: 254881-77-1.mol

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(2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate Property

Boiling point:: 321 °C
Density: 1.151
Flash point:: 148 °C
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 9.05±0.40(Predicted)
form: solid
color: Brown

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Safety

HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific

Product number: OR30679
Product name: 1-tert-Butyl2-methyl(2R,4S)-4-aminopyrrolidine-1,2-dicarboxylate
Packaging: 250mg
Price: $106
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB153083
Product name: (2R,4S)-1-tert-Butyl 2-methyl4-aminopyrrolidine-1,2-dicarboxylate
Packaging: 5mg
Price: $117
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-TG
Product name: Methyl (2R,4S)-4-aminopyrrolidine-2-carboxylate, N1-Boc protected
Packaging: 250mg
Price: $125
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB153083
Product name: (2R,4S)-1-tert-Butyl 2-methyl4-aminopyrrolidine-1,2-dicarboxylate
Packaging: 10mg
Price: $203
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB153083
Product name: (2R,4S)-1-tert-Butyl 2-methyl4-aminopyrrolidine-1,2-dicarboxylate
Packaging: 25mg
Price: $405
Updated: 2021/12/16

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(2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate Chemical Properties,Usage,Production

Synthesis

185304-04-5

254881-77-1

(2R,4S)-1-tert-butyl 2-methyl-4-azido pyrrolidine-1,2-dicarboxylate (150 mg, 0.390 mmol) was used as a raw material, which was added to methanol (15 mL) together with Pd/C (150 mg, 0.390 mmol). The reaction system was replaced with hydrogen twice, followed by stirring the reaction for 15 h at room temperature. Upon completion of the reaction, the reaction mixture was concentrated to afford methyl (2R,4S)-1-Boc-4-amino-2-pyrrolidinecarboxylate as a gray oil (643 mg, 89% yield). The product was characterized by 1H NMR (600 MHz, CD3OD): δ 4.38-4.41 (m, 1H), 3.74-3.75 (m, 3H), 3.64-3.69 (m, 1H), 3.58-3.61 (m, 1H), 3.16-3.21 (m, 1H), 2.08-2.13 (m, 2H), 1.42- 1.48 (m, 9H); MS-ESI: m/z 145.20 [M+H-100]+.

References

[1] Patent: WO2016/34134, 2016, A1. Location in patent: Paragraph 00803
[2] Journal of Medicinal Chemistry, 2000, vol. 43, # 26, p. 4948 - 4963
[3] Tetrahedron, 1996, vol. 52, # 47, p. 15017 - 15030
[4] Journal of Organic Chemistry, 2018, vol. 83, # 8, p. 4491 - 4504

(2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate Preparation Products And Raw materials

Raw materials

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View Lastest Price from (2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate manufacturers

Career Henan Chemical Co

Product: (2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate 254881-77-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-08

254881-77-1, (2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylateRelated Search:

Acetonitrile 4-Dimethylaminobenzoic acid 4-Dimethylaminopyridine Betaine 4-Dimethylaminobenzaldehyde Basic Violet 1 Glycine DIETHYL BIPHENYL-4,4'-DICARBOXYLATE Kresoxim-methyl Methanol ALTRENOGEST Methyl acrylate Methyl acetate Paraquat dichloride Methylparaben Methyl Methyl pyrrolidine-2-carboxylate hydrochloride BOC-D-PRO-OME

(2R,4S)-4-Amino-1,2-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 2-methyl ester

Methyl (2R,4S)-4-aminopyrrolidine-2-carboxylate, N1-BOC protected

1-tert-Butyl 2-methyl (2R,4S)-4-aminopyrrolidine-1,2-dicarboxylate

Methyl (2R,4S)-4-AMino-1-Boc-2-pyrrolidinedicarboxylate

Methyl (2R,4S)-4-AMino-1-Boc-2-pyrrolidinecarboxylate

(2R,4S)-4-AMINO-1-BOC-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER-HCl

Methyl (2R,4S)-1-(tert-butoxycarbonyl)-4-aMinopyrrolidine-2-carboxylate

Methyl (2R,4S)-4-aminopyrrolidine-2-carboxylate, N1-BOC protected, trans-4-Amino-D-proline methyl ester, N1-BOC protected, (2R,4S)-4-amino-1-(tert-butoxycarbonyl)-2-(methoxycarbonyl)pyrrolidine

(2R,4S)-4-Amino-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) 2-methyl ester

(2r,4s)-1-tert-butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate

1,2-Pyrrolidinedicarboxylic acid, 4-amino-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4S)-

(4S)-4-Amino-1-Boc-D-proline methyl ester

1-(1,1-Dimethylethyl) 2-methyl (2R,4S)-4-amino-1,2-pyrrolidinedicarboxylate

(2R,4S)-N-Boc-4-amino-D-proline methyl ester

1-(tert-Butyl) 2-methyl (2R,4S)-4-amino-1,2-pyrrolidinedicarboxylate

254881-77-1