(1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE

Product Name: (1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE
CAS No.: 113451-59-5
Chemical Name: (1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE
Synonyms: EOS-61878;(1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE;(1S,4S)-5-Boc-2,5-diazabicyclo[2.2.1]heptane;(1S,4S)-N-BOC-2,5-DIAZA-BICYCLO[2.2.1]HEPTANE;(1S,4S)-2-T-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE;(1S,4S)-(-)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE;(1S,4S)-2-N-T-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE;(1S,4S)-2-Boc-2,5-diazabicyclo2.2.1üheptane, 97%;(1S,4S)-2,5-Diazabicyclo(2,2,1)Heptane-2-Carboxylate;(1S,4S)-(-)-2-BOC-2,5-diazabicyclo[2.2.1]heptane,95%
CBNumber: CB7158599
Molecular Formula: C10H18N2O2
Formula Weight: 198.26
MOL File: 113451-59-5.mol

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(1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE Property

Melting point:: 74-76 °C(lit.)
alpha: -44o (C=1 IN CHLOROFORM)
Boiling point:: 276.4±15.0 °C(Predicted)
Density: 1.104±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Powder
pka: 9.74±0.20(Predicted)
color: White to slightly beige
optical activity: [α]22/D 44°, c = 1 in chloroform
Water Solubility: Insoluble in water.
Sensitive: Air Sensitive
BRN: 6460311
InChI: InChI=1S/C10H18N2O2/c1-10(2,3)14-9(13)12-6-7-4-8(12)5-11-7/h7-8,11H,4-6H2,1-3H3/t7-,8-/m0/s1
InChIKey: UXAWXZDXVOYLII-YUMQZZPRSA-N
SMILES: [C@]12([H])C[C@]([H])(NC1)CN2C(OC(C)(C)C)=O
CAS DataBase Reference: 113451-59-5(CAS DataBase Reference)

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Safety

Risk Statements: 34
Safety Statements: 22-24/25-45-36/37/39-26
RIDADR: 3263
WGK Germany: 3
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 473049
Product name: (1S,4S)-(?)-2-Boc-2,5-diazabicyclo[2.2.1]heptane
Purity: 95%
Packaging: 1g
Price: $186
Updated: 2025/07/31

Sigma-Aldrich

Product number: 473049
Product name: (1S,4S)-(?)-2-Boc-2,5-diazabicyclo[2.2.1]heptane
Purity: 95%
Packaging: 5g
Price: $525
Updated: 2025/07/31

TCI Chemical

Product number: D6152
Product name: tert-Butyl (1S,4S)-2,5-Diazabicyclo[2.2.1]heptane-2-carboxylate
Purity: min. 98.0 %
Packaging: 1G
Price: $97
Updated: 2025/07/31

TRC

Product number: B646558
Product name: (1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane
Packaging: 250mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B646558
Product name: (1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane
Packaging: 500mg
Price: $60
Updated: 2021/12/16

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(1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE Chemical Properties,Usage,Production

Chemical Properties

White to slightly beige powder

Uses

It is used as an active pharmaceutical intermediate.

Synthesis

113451-54-0

113451-59-5

Methylsulfonate 17 (1.2 g, 3.78 mmol) was used as raw material, which was suspended in anhydrous THF (38 mL), triphenylphosphine (1.48 g, 5.66 mmol) was added, and the reaction was stirred at room temperature for 2 hours. Subsequently, H2O (0.5 mL) was added and stirring was continued for 18 hours. Upon completion of the reaction, the solvent was removed under reduced pressure and the residue was suspended in 1 M hydrochloric acid (150 mL) and extracted with CH2Cl2 (2 x 70 mL). The aqueous layer was adjusted to pH 14 with base and then extracted with CH2Cl2 (3 × 70 mL). The organic phases were combined, washed with brine (100 mL), dried over anhydrous MgSO4 and concentrated under reduced pressure. Purification by rapid chromatography on silica gel with the eluent CH2Cl2-methanol-ammonia (90:9:1) afforded the target product amine 18 (0.52 g, 2.62 mmol, 71% yield) as a colorless solid. The product characterization data were as follows: melting point 76.8-77.9 °C; specific spin [α]D -47.6 (c 1.0, CHCl3); IR spectra (νmax/cm-1) 2975, 1688, 1408, 1170; 1H NMR (500 MHz, CDCl3) δ 4.43 (0.5H, s), 4.30 (0.5H, s), 3.69 (1H, s), 3.38-3.32 (1H, m), 3.19-3.13 (1H, m), 3.06-2.97 (2H, m), 1.75-1.65 (2H, m), 1.45-1.43 (9H, m); 13C NMR (125 MHz, CDCl3) δ 154.6, 154.3, 79.6, 79.5, 57.3, 56.6, 56.5, 56.3, 56.1, 52.8, 52.7, 37.2, 37.0, 28.66; mass spectra (APCI) m/z 199 ([M+H]+, 100).

References

[1] Journal of Organic Chemistry, 1988, vol. 53, # 7, p. 1580 - 1582
[2] Tetrahedron Letters, 2013, vol. 54, # 39, p. 5345 - 5347

(1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE Preparation Products And Raw materials

Raw materials

Preparation Products

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(1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE Suppliers

Austria 1 Belgium 3 China 163 Europe 2 France 1 Germany 5 India 7 Japan 3 Switzerland 2 The Netherlands 2 United Kingdom 6 United States 30 Global 225

Shanghai Join Biological Pharmaceutical Co., Ltd.

Tel: 13818361018
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Chengdu Dorher Pharmaceutical CO.,Ltd

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Chengdu Firster Pharmaceutical Co., Ltd.

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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
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Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
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Advantage: 61

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
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Advantage: 84

Ark Pharm, Inc.

Tel: 847-367-3680
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Country: United States
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Energy Chemical

Tel: 021-021-58432009 400-005-6266
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Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
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Country: China
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Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
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View Lastest Price from (1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: (1S,4S)-()-2-Boc-2,5-diazabicyclo[2.2.1]heptane 113451-59-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: (1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE 113451-59-5
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%min
Supply Ability: 500kg
Release date: 2018-12-20

113451-59-5, (1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANERelated Search:

tert-Butyl 3-aminopyrrolidine-1-carboxylate (S)-3-(Boc-amino)pyrrolidine (S)-1-N-Boc-2-methylpiperazine 2-Boc-aminomethylpyrrolidine 2-(Aminomethyl)-1-N-Boc-pyrrolidine (S)-1-Boc-3-methylpiperazine 1-Boc-2-Methylpiperazine 1-Boc-piperazine acetate (3S)-(-)-3-(DIMETHYLAMINO)PYRROLIDINE 3-N-Boc-aminopyrrolidine (S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine 1-Boc-3-Methylaminopyrrolidine 2-Methylpiperazine (S)-1-N-Boc-2-(aminomethyl)pyrrolidine (1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE 4-N-Boc-2-Methyl-piperazine 3-(N-TERT-BUTOXYCARBONYL-N-METHYLAMINO)PYRROLIDINE Heptane

TERT-BUTYL (1S, 4S)-(-)-2,5-DIAZABICYCLO[2.2.1]HEPTANE-2-CARBOXYLATE

TERT-BUTYL (1S,4S)-2,5-DIAZABICYCLO(2.2.1)HEPTANE-2-CARBOXYLATE

(1S,4S)-N-(TERT-BUTOXYCARBONYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE

(1S,4S)-(-)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE

(1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE

(1S,4S)-2-T-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE

(1S,4S)-2-N-T-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE

(1S,4S)-N-BOC-2,5-DIAZA-BICYCLO[2.2.1]HEPTANE

N-(tert-Butoxycarbonyl)-2,5-diazabicyclo[2.2.1]heptane~tert-Butyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

(1S,4S)-2,5-Diazabicyclo(2,2,1)Heptane-2-Carboxylate

(1R,4R)-2-N-t-BOC-2,5-Diazabicyclo[2.2.1]heptane HBr

1,1-DIMETHYLETHYL (1S,4S)-2,5-DIAZABICYCLO(2.2.1)HEPTANE-2-CARBOXYLATE

n-(tert-butoxycarbonyl)-2,5-diazabicyclo[2.2.1]heptane

(1S,4S)-2-Boc-2,5-diazabicyclo2.2.1üheptane, 97%

(1S,4S)-2-N-T-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE HYDROBROMIDE

(1S,4S)-tert-butyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

(1S,4S)-(-)-2-BOC-2,5-diazabicyclo[2.2.1]heptane,95%

tert-Butyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-carboxylate

(1S,4S)-tert-butyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate hydrochloride

2,5-Diazabicyclo[2.2.1]heptane-2-carboxylicacid, 1,1-diMethylethyl ester

(1S,4S)-5-Boc-2,5-diazabicyclo[2.2.1]heptane

(1S,4S)-2,5-DIAZA-BICYCLO(2.2.1)HEPTANE-2-CARBOXYLICACIDTERT-BUTYLESTER

EOS-61878

(1S,4S)-(-)-2-Boc-2,5-diazabicyclo[2.2.1]heptane 95%

2,5-Diazabicyclo[2.2.1]heptane-2-carboxylicacid, 1,1-dimethylethyl ester, (1S,4S)-

(1S,4S)-2-Boc-2,5-diazabicyclo(2.2.1)heptane methanesulfonic acid salt

(1<i>S</i>,4<i>S</i>)-(?)-2-Boc-2,5-diazabicyclo[2.2.1]heptane

(1S,4S)-N-Boc-2,5-diazabicyclo[2.2.1]heptane - [B6590]

113451-59-5

C10H20Br2N2O2

Chiral Building Blocks

Asymmetric Synthesis

Heterocyclic Building Blocks

Others

Heterocycle-other series