1-Boc-3-Methylaminopyrrolidine
- Product Name
- 1-Boc-3-Methylaminopyrrolidine
- CAS No.
- 454712-26-6
- Chemical Name
- 1-Boc-3-Methylaminopyrrolidine
- Synonyms
- 1-BOC-3-METHYLAMINOPYRROLIDINE;N-BOC-3-Methylaminopyrrolidine;1-Boc-3-methylaminopyrrolidine ,98%;1-Boc-3-Methylaminopyrrolidine USP/EP/BP;1-(tert-Butyloxycarbonyl)-3-methylaminopyrro;3-Methylamino-1-tert-butoxycarbonylpyrrolidine;1-(tert-Butyloxycarbonyl)-3-methylaminopyrrolidine;tert-butyl 3-(methylamino)pyrrolidine-1-carboxylate;3-METHYLAMINO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;3-(Methylamino)-1-pyrrolidinecarboxylic acid, 1,1-dimethylethyl ester
- CBNumber
- CB7293924
- Molecular Formula
- C10H20N2O2
- Formula Weight
- 200.28
- MOL File
- 454712-26-6.mol
1-Boc-3-Methylaminopyrrolidine Property
- Boiling point:
- 269 °C
- Density
- 1.03
- Flash point:
- 117 °C
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- pka
- 10.02±0.20(Predicted)
- form
- solid
- Appearance
- Colorless to light yellow Liquid
- optical activity
- -1.16°(C=0.50g/100mL, CHCL3, 20°C, 589nm)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B663178
- Product name
- 1-BOC-3-Methylaminopyrrolidine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB31146
- Product name
- 1-Boc-3-Methylaminopyrrolidine
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 4H56-1-NQ
- Product name
- 3-(Methylamino)-1-pyrrolidinecarboxylic acid, 1,1-dimethylethyl ester
- Packaging
- 250mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- FB31146
- Product name
- 1-Boc-3-Methylaminopyrrolidine
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- X3037
- Product name
- 1-Boc-3-Methylaminopyrrolidine
- Packaging
- 5g
- Price
- $135
- Updated
- 2021/12/16
1-Boc-3-Methylaminopyrrolidine Chemical Properties,Usage,Production
Synthesis
101385-93-7
74-89-5
454712-26-6
GENERAL STEPS: To a solution of 1-(tert-butoxycarbonyl)pyrrolidin-3-one (74 g, 0.4 mol) in methanol (450 mL) was slowly added a methanolic solution of methylamine (137.8 g, 1.2 mol) at 0 °C. The reaction mixture was stirred at room temperature for 2 hours. Subsequently, sodium borohydride (15.2 g, 0.4 mol) was added in batches and stirring was continued for 1 hour at room temperature. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent to give the crude product. The crude product was extracted by partitioning between dichloromethane (3 x 500 mL) and water (300 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford 1-(tert-butoxycarbonyl)-3-methylaminopyrrolidine (74 g, 92.5% yield), which could be used in the next reaction without further purification. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 3.54 (m, 4H), 3.29 (m, 2H), 2.45 (s, 3H), 2.20 (m, 1H), 1.38 (s, 9H).
References
[1] Patent: WO2009/76387, 2009, A1. Location in patent: Page/Page column 42
[2] Patent: US2015/252021, 2015, A1. Location in patent: Paragraph 0307; 0308
[3] Patent: WO2012/127506, 2012, A1. Location in patent: Page/Page column 108-109
[4] ChemCatChem, 2018, vol. 10, # 3, p. 510 - 514
[5] Patent: WO2007/122410, 2007, A1. Location in patent: Page/Page column 101; 106
1-Boc-3-Methylaminopyrrolidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Boc-3-Methylaminopyrrolidine manufacturers
- Product
- 1-Boc-3-MethylaMinopyrrolidine 454712-26-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2025-04-07
- Product
- 1-Boc-3-Methylaminopyrrolidine 454712-26-6
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08