1-(tert-Butoxycarbonyl)-3-pyrrolidinol

Product Name: 1-(tert-Butoxycarbonyl)-3-pyrrolidinol
CAS No.: 103057-44-9
Chemical Name: 1-(tert-Butoxycarbonyl)-3-pyrrolidinol
Synonyms: Tert-butyl 3-hydroxypyrrolidine-1-carboxylate;1-BOC-3-HYDROXYPYRROLIDINE;3-HYDROXY-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Pyrrolidinecarboxylic acid, 3-hydroxy-, 1,1-diMethylethyl ester;Zinc00403504;CAS:103057-44-9;N-boc-3-Pyrrolidinol;1-Boc-3-HydroxypyrroL;1-Boc-3-hydropyrrolidine;1-Boc-3-pyrrolidinol 95%
CBNumber: CB7232378
Molecular Formula: C9H17NO3
Formula Weight: 187.24
MOL File: 103057-44-9.mol

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1-(tert-Butoxycarbonyl)-3-pyrrolidinol Property

Melting point:: 62.1-62.2°C
Boiling point:: 273.3±33.0 °C(Predicted)
Density: 1.142±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: soluble in Methanol
form: powder to crystal
pka: 14.74±0.20(Predicted)
color: White to Almost white
optical activity: Consistent with structure
InChI: InChI=1S/C9H17NO3/c1-9(2,3)13-8(12)10-5-4-7(11)6-10/h7,11H,4-6H2,1-3H3
InChIKey: APCBTRDHCDOPNY-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(O)C1
CAS DataBase Reference: 103057-44-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T
Risk Statements: 36/37/38-25
Safety Statements: 26-36/37/39-37-45-36/37
RIDADR: 2811
WGK Germany: 2
HazardClass: IRRITANT
PackingGroup: Ⅲ
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 706620
Product name: 1-Boc-3-pyrrolidinol
Purity: 95%
Packaging: 5g
Price: $118
Updated: 2025/07/31

Sigma-Aldrich

Product number: 706620
Product name: 1-Boc-3-pyrrolidinol
Purity: 95%
Packaging: 1g
Price: $29
Updated: 2023/06/20

TCI Chemical

Product number: B3603
Product name: 1-(tert-Butoxycarbonyl)-3-pyrrolidinol
Purity: >98.0%(GC)
Packaging: 5g
Price: $101
Updated: 2025/07/31

TCI Chemical

Product number: B3603
Product name: 1-(tert-Butoxycarbonyl)-3-pyrrolidinol
Purity: >98.0%(GC)
Packaging: 25g
Price: $287
Updated: 2025/07/31

TRC

Product number: B665900
Product name: 1-Boc-3-pyrrolidinol
Packaging: 100mg
Price: $45
Updated: 2021/12/16

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1-(tert-Butoxycarbonyl)-3-pyrrolidinol Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

1-Boc-3-pyrrolidinol is an intermediate for the preparation of pyrrolidinone-containing pseudopeptides, inhibitors of HIV-1 protease.

Synthesis

24424-99-5

40499-83-0

83220-73-9

The general procedure for the synthesis of 1-tert-butoxycarbonyl-3-hydroxy-pyrrolidine from di-tert-butyl dicarbonate and 3-hydroxy-pyrrolidine was carried out as follows: firstly, (R)-3-pyrrolidinol (539 mg, 6.19 mmol) was converted to compound 16b to afford the colorless oily material (1.3 g, 100% yield). The spectral data of this compound were consistent with the expected structure and in accordance with literature reports (see Kucznierz, R. et al. J. Med. Chem. 1998, 41, 4983-4994). Subsequently, compound 16b was converted by reaction to compound 16c, again as a colorless oil. Next, compound 16c was converted by a two-step reaction to compound 16e, still a colorless oily substance. Finally, compound 16e was reacted to produce the target compound 16, which was rendered as a yellow oily substance.

References

[1] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 10, p. 969 - 973
[2] Patent: WO2015/9731, 2015, A2. Location in patent: Paragraph 00106
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 25, p. 4983 - 4994
[4] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 17, p. 5812 - 5832
[5] Patent: WO2010/84767, 2010, A1. Location in patent: Page/Page column 86

1-(tert-Butoxycarbonyl)-3-pyrrolidinol Preparation Products And Raw materials

Raw materials

Preparation Products

1-Boc-3-Methylaminopyrrolidine tert-Butyl 3-aminopyrrolidine-1-carboxylate

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1-(tert-Butoxycarbonyl)-3-pyrrolidinol Suppliers

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View Lastest Price from 1-(tert-Butoxycarbonyl)-3-pyrrolidinol manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 1-(tert-Butoxycarbonyl)-3-pyrrolidinol 103057-44-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-22

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1-(tert-Butoxycarbonyl)-3-pyrrolidinol 103057-44-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-06

Career Henan Chemical Co

Product: (R)-1-Boc-3-hydroxypyrrolidine 103057-44-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2018-08-08

103057-44-9, 1-(tert-Butoxycarbonyl)-3-pyrrolidinolRelated Search:

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1-(tert-Butoxycarbonyl)-3-pyrrolidinol &gt

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tert-Butyl-(3S)-3-hydroxypyrrolidin-1-carboxylate

CAS:103057-44-9

1-Boc-3-pyrrolidinol(tert-butyl 3-hydroxypyrrolidine-1-carboxylate

103057-44-9

C9H17NO3

C9H17O3N

Aliphatics

Alcohols and Derivatives

Heterocycles

Pyrrolidines

Pyrrole&Pyrrolidine&Pyrroline

pharmacetical