ChemicalBook > CAS DataBase List > 1-(tert-Butoxycarbonyl)-3-pyrrolidinol

1-(tert-Butoxycarbonyl)-3-pyrrolidinol

Product Name
1-(tert-Butoxycarbonyl)-3-pyrrolidinol
CAS No.
103057-44-9
Chemical Name
1-(tert-Butoxycarbonyl)-3-pyrrolidinol
Synonyms
Tert-butyl 3-hydroxypyrrolidine-1-carboxylate;1-BOC-3-HYDROXYPYRROLIDINE;3-HYDROXY-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Pyrrolidinecarboxylic acid, 3-hydroxy-, 1,1-diMethylethyl ester;Zinc00403504;CAS:103057-44-9;N-boc-3-Pyrrolidinol;1-Boc-3-HydroxypyrroL;1-Boc-3-hydropyrrolidine;1-Boc-3-pyrrolidinol 95%
CBNumber
CB7232378
Molecular Formula
C9H17NO3
Formula Weight
187.24
MOL File
103057-44-9.mol
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1-(tert-Butoxycarbonyl)-3-pyrrolidinol Property

Melting point:
62.1-62.2°C
Boiling point:
273.3±33.0 °C(Predicted)
Density 
1.142±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
soluble in Methanol
form 
powder to crystal
pka
14.74±0.20(Predicted)
color 
White to Almost white
optical activity
Consistent with structure
InChI
InChI=1S/C9H17NO3/c1-9(2,3)13-8(12)10-5-4-7(11)6-10/h7,11H,4-6H2,1-3H3
InChIKey
APCBTRDHCDOPNY-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(O)C1
CAS DataBase Reference
103057-44-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
36/37/38-25
Safety Statements 
26-36/37/39-37-45-36/37
RIDADR 
2811
WGK Germany 
2
HazardClass 
IRRITANT
PackingGroup 
Ⅲ
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
706620
Product name
1-Boc-3-pyrrolidinol
Purity
95%
Packaging
5g
Price
$118
Updated
2025/07/31
Sigma-Aldrich
Product number
706620
Product name
1-Boc-3-pyrrolidinol
Purity
95%
Packaging
1g
Price
$29
Updated
2023/06/20
TCI Chemical
Product number
B3603
Product name
1-(tert-Butoxycarbonyl)-3-pyrrolidinol
Purity
>98.0%(GC)
Packaging
5g
Price
$101
Updated
2025/07/31
TCI Chemical
Product number
B3603
Product name
1-(tert-Butoxycarbonyl)-3-pyrrolidinol
Purity
>98.0%(GC)
Packaging
25g
Price
$287
Updated
2025/07/31
TRC
Product number
B665900
Product name
1-Boc-3-pyrrolidinol
Packaging
100mg
Price
$45
Updated
2021/12/16
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1-(tert-Butoxycarbonyl)-3-pyrrolidinol Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

1-Boc-3-pyrrolidinol is an intermediate for the preparation of pyrrolidinone-containing pseudopeptides, inhibitors of HIV-1 protease.

Synthesis

24424-99-5

40499-83-0

83220-73-9

The general procedure for the synthesis of 1-tert-butoxycarbonyl-3-hydroxy-pyrrolidine from di-tert-butyl dicarbonate and 3-hydroxy-pyrrolidine was carried out as follows: firstly, (R)-3-pyrrolidinol (539 mg, 6.19 mmol) was converted to compound 16b to afford the colorless oily material (1.3 g, 100% yield). The spectral data of this compound were consistent with the expected structure and in accordance with literature reports (see Kucznierz, R. et al. J. Med. Chem. 1998, 41, 4983-4994). Subsequently, compound 16b was converted by reaction to compound 16c, again as a colorless oil. Next, compound 16c was converted by a two-step reaction to compound 16e, still a colorless oily substance. Finally, compound 16e was reacted to produce the target compound 16, which was rendered as a yellow oily substance.

References

[1] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 10, p. 969 - 973
[2] Patent: WO2015/9731, 2015, A2. Location in patent: Paragraph 00106
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 25, p. 4983 - 4994
[4] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 17, p. 5812 - 5832
[5] Patent: WO2010/84767, 2010, A1. Location in patent: Page/Page column 86

1-(tert-Butoxycarbonyl)-3-pyrrolidinol Preparation Products And Raw materials

Raw materials

Preparation Products

1-Boc-3-Methylaminopyrrolidine tert-Butyl 3-aminopyrrolidine-1-carboxylate
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1-(tert-Butoxycarbonyl)-3-pyrrolidinol Suppliers

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View Lastest Price from 1-(tert-Butoxycarbonyl)-3-pyrrolidinol manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
1-(tert-Butoxycarbonyl)-3-pyrrolidinol 103057-44-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-22
Hebei Chuanghai Biotechnology Co., Ltd
Product
1-(tert-Butoxycarbonyl)-3-pyrrolidinol 103057-44-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-12-06
Career Henan Chemical Co
Product
(R)-1-Boc-3-hydroxypyrrolidine 103057-44-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2018-08-08

103057-44-9, 1-(tert-Butoxycarbonyl)-3-pyrrolidinolRelated Search:

BUTYL OLEATE N-Methyl-2-pyrrolidone Polyvinylpyrrolidone Pyrrolidine tert-Butanol N-Vinyl-2-pyrrolidone tert-Butyl peroxyacetate tert-Butyl acetate Butyl acetate 3-Pyrrolidinol Buprofezin Tris(trimethylsilyl)phosphate CHLOROPHOSPHONAZO III Cyhalofop-butyl 1-Boc-3-methylideneazetid... Butyl acrylate METHYL-2-PYRROLIDONE N-Boc-trans-4-tosyloxy-L-proline methyl ester

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  • t-Butyl 3-hydroxypyrrolidine-1-carboxylate
  • 1-Pyrrolidinecarboxylic acid, 3-hydroxy-, 1,1-diMethylethyl ester
  • (R)-tert-butyl 3-hydro×ypyrrolidine-1-carbo×ylate
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  • 1,1-DiMethylethyl 3-Hydroxypyrrolidine-1-carboxylate
  • 1-Boc-3-pyrrolidinol 1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine 1-Boc-3-hydroxypyrrolidine
  • tert-Butyl 3-hydroxypyrrolidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine
  • (R)-1-Boc-3-hydroxypyrrolidine SynonyMs (R)-N-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine
  • 1-Boc-3-pyrrolidinol, >=97%
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  • 3-hydroxy-1-pyrrolidinecarboxylic acid tert-butyl ester
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  • CAS:103057-44-9
  • 1-Boc-3-pyrrolidinol(tert-butyl 3-hydroxypyrrolidine-1-carboxylate
  • 103057-44-9
  • C9H17NO3
  • C9H17O3N
  • Aliphatics
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  • Heterocycles
  • Pyrrolidines
  • Pyrrole&Pyrrolidine&Pyrroline
  • pharmacetical