3-N-Boc-aminopyrrolidine
- Product Name
- 3-N-Boc-aminopyrrolidine
- CAS No.
- 99724-19-3
- Chemical Name
- 3-N-Boc-aminopyrrolidine
- Synonyms
- TERT-BUTYL PYRROLIDIN-3-YLCARBAMATE;3-(BOC-AMINO)PYRROLIDINE;3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE;BOC-(+/-)-(3)APYROLIDI;Benzene,1-bromo-6-octyl-;3-N-BOC-AMINO PYRROLIDINE;BOC-(+/-)-3-AMINOPYRROLIDINE;3-N-Boc-aMinoMethypyrrolidine;9H-FLUORENE-2,12-DICARBOXYLICACID;3-Aminopyrrolidine, 3-BOC protected
- CBNumber
- CB5767919
- Molecular Formula
- C9H18N2O2
- Formula Weight
- 186.25
- MOL File
- 99724-19-3.mol
3-N-Boc-aminopyrrolidine Property
- Melting point:
- 67 °C
- Boiling point:
- 286.4±29.0 °C(Predicted)
- Density
- 1.04±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in Methanol(almost transparency).
- pka
- 12.37±0.20(Predicted)
- form
- powder to crystal
- color
- White to Light yellow to Light orange
- Sensitive
- Air Sensitive
- InChI
- 1S/C9H18N2O2/c1-9(2,3)13-8(12)11-7-4-5-10-6-7/h7,10H,4-6H2,1-3H3,(H,11,12)
- InChIKey
- DQQJBEAXSOOCPG-UHFFFAOYSA-N
- SMILES
- CC(C)(C)OC(=O)NC1CCNC1
- CAS DataBase Reference
- 99724-19-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 721832
- Product name
- 3-(Boc-amino)pyrrolidine
- Purity
- 95%
- Packaging
- 1g
- Price
- $67.76
- Updated
- 2025/07/31
- Product number
- B1358
- Product name
- 3-(tert-Butoxycarbonylamino)pyrrolidine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $46
- Updated
- 2025/07/31
- Product number
- B1358
- Product name
- 3-(tert-Butoxycarbonylamino)pyrrolidine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $149
- Updated
- 2025/07/31
- Product number
- A614395
- Product name
- DL-3-(BOC-Amino)pyrrolidine
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 011327
- Product name
- 3-(tert-Butoxycarbonylamino)pyrrolidine
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
3-N-Boc-aminopyrrolidine Chemical Properties,Usage,Production
Uses
(+/-)-3-(Boc-amino)pyrrolidine is the homochiral starting materials utilised in the synthesis of all of the chiral compounds. Reactant in the peptide activated G-protein coupled receptors test.
Synthesis
99735-30-5
99724-19-3
General procedure for the synthesis of 3-(Boc-amino)pyrrolidine from 1-benzyl-3-(Boc-amino)pyrrolidine: 1-benzyl-3-(Boc-amino)pyrrolidine (15.75 g, 57.0 mmol) was dissolved in a solvent mixture of methanol and tetrahydrofuran (4:1, 114 ml) in a 500 ml reaction vessel. A catalytic amount of 10% palladium/carbon (Pd/C) was added to the solution. The reaction mixture was stirred and reacted for 12 hours under hydrogen atmosphere. Upon completion of the reaction, the palladium/carbon catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure to remove the solvent. The resulting residue was purified by silica gel column chromatography to afford 3-(Boc-amino)pyrrolidine (9.51 g, 99% yield). The product was characterized by 1H-NMR (200 MHz, CDCl3): δ 1.41 (s, 9H), 2.26 (m, 2H), 2.55 (m, 3H), 2.74 (m, 1H), 4.84 (br, 1H).LC-MS analysis showed [M+H]+ peak of 187.
References
[1] Patent: WO2008/54154, 2008, A1. Location in patent: Page/Page column 76; 81; 162-163; 168
[2] Patent: WO2007/52938, 2007, A1. Location in patent: Page/Page column 23
[3] Patent: US5281612, 1994, A
[4] Patent: US4604401, 1986, A
[5] Patent: US4617308, 1986, A
3-N-Boc-aminopyrrolidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-N-Boc-aminopyrrolidine manufacturers
- Product
- 3-N-Boc-aminopyrrolidine 99724-19-3
- Price
- US $8.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-25