ChemicalBook > CAS DataBase List > 3-N-Boc-aminopyrrolidine

3-N-Boc-aminopyrrolidine

Product Name: 3-N-Boc-aminopyrrolidine
CAS No.: 99724-19-3
Chemical Name: 3-N-Boc-aminopyrrolidine
Synonyms: TERT-BUTYL PYRROLIDIN-3-YLCARBAMATE;3-(BOC-AMINO)PYRROLIDINE;3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE;BOC-(+/-)-(3)APYROLIDI;Benzene,1-bromo-6-octyl-;3-N-BOC-AMINO PYRROLIDINE;BOC-(+/-)-3-AMINOPYRROLIDINE;3-N-Boc-aMinoMethypyrrolidine;9H-FLUORENE-2,12-DICARBOXYLICACID;3-Aminopyrrolidine, 3-BOC protected
CBNumber: CB5767919
Molecular Formula: C9H18N2O2
Formula Weight: 186.25
MOL File: 99724-19-3.mol

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3-N-Boc-aminopyrrolidine Property

Melting point:: 67 °C
Boiling point:: 286.4±29.0 °C(Predicted)
Density: 1.04±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in Methanol(almost transparency).
pka: 12.37±0.20(Predicted)
form: powder to crystal
color: White to Light yellow to Light orange
Sensitive: Air Sensitive
InChIKey: DQQJBEAXSOOCPG-UHFFFAOYSA-N
CAS DataBase Reference: 99724-19-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 721832
Product name: 3-(Boc-amino)pyrrolidine
Purity: 95%
Packaging: 1g
Price: $67.76
Updated: 2025/07/31

TCI Chemical

Product number: B1358
Product name: 3-(tert-Butoxycarbonylamino)pyrrolidine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $46
Updated: 2025/07/31

TCI Chemical

Product number: B1358
Product name: 3-(tert-Butoxycarbonylamino)pyrrolidine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $149
Updated: 2025/07/31

TRC

Product number: A614395
Product name: DL-3-(BOC-Amino)pyrrolidine
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Oakwood

Product number: 011327
Product name: 3-(tert-Butoxycarbonylamino)pyrrolidine
Packaging: 1g
Price: $10
Updated: 2021/12/16

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3-N-Boc-aminopyrrolidine Chemical Properties,Usage,Production

Uses

(+/-)-3-(Boc-amino)pyrrolidine is the homochiral starting materials utilised in the synthesis of all of the chiral compounds. Reactant in the peptide activated G-protein coupled receptors test.

Synthesis

99735-30-5

99724-19-3

General procedure for the synthesis of 3-(Boc-amino)pyrrolidine from 1-benzyl-3-(Boc-amino)pyrrolidine: 1-benzyl-3-(Boc-amino)pyrrolidine (15.75 g, 57.0 mmol) was dissolved in a solvent mixture of methanol and tetrahydrofuran (4:1, 114 ml) in a 500 ml reaction vessel. A catalytic amount of 10% palladium/carbon (Pd/C) was added to the solution. The reaction mixture was stirred and reacted for 12 hours under hydrogen atmosphere. Upon completion of the reaction, the palladium/carbon catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure to remove the solvent. The resulting residue was purified by silica gel column chromatography to afford 3-(Boc-amino)pyrrolidine (9.51 g, 99% yield). The product was characterized by 1H-NMR (200 MHz, CDCl3): δ 1.41 (s, 9H), 2.26 (m, 2H), 2.55 (m, 3H), 2.74 (m, 1H), 4.84 (br, 1H).LC-MS analysis showed [M+H]+ peak of 187.

References

[1] Patent: WO2008/54154, 2008, A1. Location in patent: Page/Page column 76; 81; 162-163; 168
[2] Patent: WO2007/52938, 2007, A1. Location in patent: Page/Page column 23
[3] Patent: US5281612, 1994, A
[4] Patent: US4604401, 1986, A
[5] Patent: US4617308, 1986, A

3-N-Boc-aminopyrrolidine Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Acetonitrile Calcium chloride Di-tert-butyl dicarbonate Sodium borohydride Triethylamine Methanesulfonyl chloride 1,4-Dioxane DL-Aspartic acid Dichloromethane Methanol

Preparation Products

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View Lastest Price from 3-N-Boc-aminopyrrolidine manufacturers

Career Henan Chemical Co

Product: 3-N-Boc-aminopyrrolidine 99724-19-3
Price: US $8.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-25

99724-19-3, 3-N-Boc-aminopyrrolidineRelated Search:

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3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE

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BOC-(+/-)-(3)APYROLIDI

TERT-BUTYL PYRROLIDIN-3-YLCARBAMATE

PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER

N-3-(+/-)-T-BUTOXYCARBONYL-3-AMINOPYRROLIDINE

3-(BOC-AMINO)PYRROLIDINE HYDROCHLORIDE

3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE 98+%

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3-(tert-Butoxycarbonylamino) pyrrolidine ,96%

tert-Butyl pyrrolidin-3-ylcarbamate, 3-[(tert-Butoxycarbonyl)amino]pyrrolidine

3-N-Boc-aMinoMethypyrrolidine

3-(tert-Butoxycarbonylamino)pyrrolidine &gt

Benzene,1-bromo-6-octyl-

9H-FLUORENE-2,12-DICARBOXYLICACID

3-N-Boc-amino pyrrolidine, CAS 99724-19-3

99724-19-3

3-Aminopyrrolidines

3-Aminopyrrolidines (Racemic)

3-Aminopyrrolidines

3-Aminopyrrolidines (Racemic)

Amines

Pyrrolidines

pharmacetical

Pyrrole&Pyrrolidine&Pyrroline