tert-Butyl 4-aminobenzoate

Product Name: tert-Butyl 4-aminobenzoate
CAS No.: 18144-47-3
Chemical Name: tert-Butyl 4-aminobenzoate
Synonyms: BUTTPARK 14\02-67;tert-Butyl 4-aminobe;ert-butyl4-aminobenzoate;Tert-Butyl p-aMinobenzoate;TERT-BUTYL 4-AMINOBENZOATE;tert-butyl 4-azanylbenzoate;4-(tert-Butoxycarbonyl)aniline;tert-Butyl 4-Aminobenzoate >tert-butyl 4-aminobenzoate 98%;1,1-Dimethylethyl 4-aminobenzoate
CBNumber: CB5329814
Molecular Formula: C11H15NO2
Formula Weight: 193.24
MOL File: 18144-47-3.mol

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tert-Butyl 4-aminobenzoate Property

Melting point:: 108-110 °C
Boiling point:: 322.4±15.0 °C(Predicted)
Density: 1.078±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: powder to crystal
pka: 2.43±0.10(Predicted)
color: White to Light yellow to Light orange
BRN: 2803178
Major Application: peptide synthesis
InChI: InChI=1S/C11H15NO2/c1-11(2,3)14-10(13)8-4-6-9(12)7-5-8/h4-7H,12H2,1-3H3
InChIKey: KYORUZMJUKHKFS-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)C1=CC=C(N)C=C1
CAS DataBase Reference: 18144-47-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 10-34
Hazard Note: Irritant
HS Code: 29224999
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 06975
Product name: tert-Butyl 4-aminobenzoate
Purity: ≥98.0% (NT)
Packaging: 5g
Price: $116.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: 06975
Product name: tert-Butyl 4-aminobenzoate
Purity: ≥98.0% (NT)
Packaging: 25g
Price: $387
Updated: 2025/07/31

TCI Chemical

Product number: B3504
Product name: tert-Butyl 4-Aminobenzoate
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $80
Updated: 2025/07/31

TCI Chemical

Product number: B3504
Product name: tert-Butyl 4-Aminobenzoate
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $228
Updated: 2025/07/31

TRC

Product number: B809723
Product name: tert-Butyl 4-Aminobenzoate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

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tert-Butyl 4-aminobenzoate Chemical Properties,Usage,Production

Uses

tert-Butyl 4-aminobenzoate can be used to synthesise structural units for antifolate and a novel liver-targeted coupling of PSN-357, a glycogen phosphorylase inhibitor for the treatment of diabetes. It can also be used in the synthesis of tert-butyl 4-aminobenzoate n-substituted derivatives^[1].

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

tert-Butyl 4-aminobenzoate is synthesised using tert-butyl 4-nitrobenzoate as raw material by chemical reaction. The specific synthesis steps are as follows:
Tert-butyl 4-nitrobenzoate (4.75 g, 21.279 mmol) was dissolved in MeOH (200 ml) and added with CAUTION was Pd/C (475 mg, 0.1 equiv. w/w) and the flask evacuated prior to purging with N2, re-evacuation and purging with H2. The mixture was stirred under H2 for 5 hours until complete. The mixture was filtered through celite and evaporated to a white solid (4.11 g, 21.269 mmol, quant.). Rf 0.29 [20% EtOAc in Hexane]. Mp. I l l - 113 0C. 1H NMR (400 MHz, CDCl3) δ 7.79 (2H, dt, J=8.6, 2.3 Hz, 2ArH), 6.61 (2H, dt, J=8.6, 2.3 Hz, 2ArH), 4.00 (2H, br s, NH2), 1.56 (9H, s, C(CH3)3) ppm. 13C NMR (100 MHz, CDCl3) δ 165.9 (C=O), 150.4 (ArC), 131.3 (ArCH), 121.7 (ArC), 113.7 (ArCH), 80.0 (C(CH3)3), 28.3 (C(CH3)3) ppm. IR (neat) υmax 3415, 3345, 3235, 2972, 1682, 1598, 1367, 1287, 1154, 1115 cm 1. HRMS mJz calc. C11H15NO2 [M+l] 194.1176, found [M+l] 194.1179.

References

[1] V. BAVETSIAS E. H. Synthesis of N-substituted derivatives of tert-butyl 4-aminobenzoate via a palladium-catalysed reaction[J]. Journal of Chemical Research-s, 2000. DOI:10.3184/030823400103168100.

tert-Butyl 4-aminobenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl 4-aminobenzoate Suppliers

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View Lastest Price from tert-Butyl 4-aminobenzoate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: tert-Butyl 4-aminobenzoate 18144-47-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kgs
Release date: 2023-05-16

Aromsyn Co., Ltd.

Product: Tert-Butyl4-aminobenzoate 18144-47-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: kgs
Release date: 2023-02-17

Career Henan Chemical Co

Product: tert-Butyl 4-aminobenzoate 18144-47-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-20

18144-47-3, tert-Butyl 4-aminobenzoateRelated Search:

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TERT-BUTYL 4-AMINOBENZOATE

4-AMINOBENZOIC ACID TERT-BUTYL ESTER

BUTTPARK 14\02-67

tert-butyl 4-azanylbenzoate

tert-Butyl 4-aminobe

4-(tert-Butoxycarbonyl)aniline

H-4-Abz-OtBu(Tert-butyl 4-AMinobenzoate)

Tert-Butyl p-aMinobenzoate

Para aMinobenzoic acidtert butyl ester

Benzoic acid, 4-aMino-,1,1-diMethylethyl ester

tert-Butyl 4-AMinobenzoate, 98.0%(GC&T

tert-Butyl 4-aminobenzoate >=98.0% (NT)

4-[[2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl]-oxomethyl]-1-piperazinecarboxylic acid tert-butyl ester

tert-Butyl 4-Aminobenzoate &gt

ert-butyl4-aminobenzoate

tert-Butyl 4-aminobenzoate USP/EP/BP

1,1-Dimethylethyl 4-aminobenzoate

<i>tert</i>-Butyl 4-aminobenzoate

tert-butyl 4-aminobenzoate 98%

18144-47-3

18114-47-3

C11H15NO2

Aromatic Amino Acids

Specialty Synthesis

Peptide Synthesis

Unnatural Amino Acid Derivatives

API intermediates

Aromatic Amino Acids

Peptide Synthesis

Unnatural Amino Acid Derivatives