tert-Butyl 4-aminobenzoate
- Product Name
- tert-Butyl 4-aminobenzoate
- CAS No.
- 18144-47-3
- Chemical Name
- tert-Butyl 4-aminobenzoate
- Synonyms
- BUTTPARK 14\02-67;tert-Butyl 4-aminobe;ert-butyl4-aminobenzoate;Tert-Butyl p-aMinobenzoate;TERT-BUTYL 4-AMINOBENZOATE;tert-butyl 4-azanylbenzoate;4-(tert-Butoxycarbonyl)aniline;tert-Butyl 4-Aminobenzoate >1,1-Dimethylethyl 4-aminobenzoate;4-AMINOBENZOIC ACID TERT-BUTYL ESTER
- CBNumber
- CB5329814
- Molecular Formula
- C11H15NO2
- Formula Weight
- 193.24
- MOL File
- 18144-47-3.mol
tert-Butyl 4-aminobenzoate Property
- Melting point:
- 108-110 °C
- Boiling point:
- 322.4±15.0 °C(Predicted)
- Density
- 1.078±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to crystal
- pka
- 2.43±0.10(Predicted)
- color
- White to Light yellow to Light orange
- BRN
- 2803178
- CAS DataBase Reference
- 18144-47-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 06975
- Product name
- tert-Butyl 4-aminobenzoate
- Purity
- ≥98.0% (NT)
- Packaging
- 5g
- Price
- $97.2
- Updated
- 2024/03/01
- Product number
- 06975
- Product name
- tert-Butyl 4-aminobenzoate
- Purity
- ≥98.0% (NT)
- Packaging
- 25g
- Price
- $375
- Updated
- 2024/03/01
- Product number
- B3504
- Product name
- tert-Butyl 4-Aminobenzoate
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $80
- Updated
- 2024/03/01
- Product number
- B3504
- Product name
- tert-Butyl 4-Aminobenzoate
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $228
- Updated
- 2024/03/01
- Product number
- B809723
- Product name
- tert-Butyl 4-Aminobenzoate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
tert-Butyl 4-aminobenzoate Chemical Properties,Usage,Production
Uses
tert-Butyl 4-aminobenzoate can be used to synthesise structural units for antifolate and a novel liver-targeted coupling of PSN-357, a glycogen phosphorylase inhibitor for the treatment of diabetes. It can also be used in the synthesis of tert-butyl 4-aminobenzoate n-substituted derivatives[1].
Synthesis
tert-Butyl 4-aminobenzoate is synthesised using tert-butyl 4-nitrobenzoate as raw material by chemical reaction. The specific synthesis steps are as follows:
Tert-butyl 4-nitrobenzoate (4.75 g, 21.279 mmol) was dissolved in MeOH (200 ml) and added with CAUTION was Pd/C (475 mg, 0.1 equiv. w/w) and the flask evacuated prior to purging with N2, re-evacuation and purging with H2. The mixture was stirred under H2 for 5 hours until complete. The mixture was filtered through celite and evaporated to a white solid (4.11 g, 21.269 mmol, quant.). Rf 0.29 [20% EtOAc in Hexane]. Mp. I l l - 113 0C. 1H NMR (400 MHz, CDCl3) δ 7.79 (2H, dt, J=8.6, 2.3 Hz, 2ArH), 6.61 (2H, dt, J=8.6, 2.3 Hz, 2ArH), 4.00 (2H, br s, NH2), 1.56 (9H, s, C(CH3)3) ppm. 13C NMR (100 MHz, CDCl3) δ 165.9 (C=O), 150.4 (ArC), 131.3 (ArCH), 121.7 (ArC), 113.7 (ArCH), 80.0 (C(CH3)3), 28.3 (C(CH3)3) ppm. IR (neat) υmax 3415, 3345, 3235, 2972, 1682, 1598, 1367, 1287, 1154, 1115 cm 1. HRMS mJz calc. C11H15NO2 [M+l] 194.1176, found [M+l] 194.1179.
References
[1] V. BAVETSIAS E. H. Synthesis of N-substituted derivatives of tert-butyl 4-aminobenzoate via a palladium-catalysed reaction[J]. Journal of Chemical Research-s, 2000. DOI:10.3184/030823400103168100.
tert-Butyl 4-aminobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from tert-Butyl 4-aminobenzoate manufacturers
- Product
- tert-Butyl 4-aminobenzoate 18144-47-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kgs
- Release date
- 2023-05-16
- Product
- Tert-Butyl 4-aminobenzoate 18144-47-3
- Price
- US $30.00-20.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2024-05-16
- Product
- Tert-Butyl4-aminobenzoate 18144-47-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- kgs
- Release date
- 2023-02-17