4-N-Boc-2-Methyl-piperazine

Product Name: 4-N-Boc-2-Methyl-piperazine
CAS No.: 120737-59-9
Chemical Name: 4-N-Boc-2-Methyl-piperazine
Synonyms: Boc-3-methylpiperazine;1-Boc-3-methyl-piperazine;2-METHYL-4-BOC-PIPERAZINE;4-BOC-2-METHYL PIPERAZINE;N-Boc-3-Methyl-Piperazine;1-N-Boc-3-methylpiperizine;N-1-BOC-3-METHYL PIPERIZINE;N-1-BOC-3-METHYL PIPERAZINE;4-N-BOC-2-METHYL-PIPERAZINE;(+-)-N4-Boc-2-methylpiperazine
CBNumber: CB8170798
Molecular Formula: C10H20N2O2
Formula Weight: 200.28
MOL File: 120737-59-9.mol

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4-N-Boc-2-Methyl-piperazine Property

Boiling point:: 268.7±15.0 °C(Predicted)
Density: 0.997±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Chloroform, DMSO, Ethyl Acetate
pka: 8.52±0.40(Predicted)
form: Oil
color: Clear Colourless
InChI: InChI=1S/C10H20N2O2/c1-8-7-12(6-5-11-8)9(13)14-10(2,3)4/h8,11H,5-7H2,1-4H3
InChIKey: FMLPQHJYUZTHQS-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCNC(C)C1
CAS DataBase Reference: 120737-59-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,N
Risk Statements: 36/37/38-50
Safety Statements: 26-36/37/39-61-37
RIDADR: UN3077
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B656980
Product name: 4-N-Boc-2-methylpiperazine
Packaging: 50g
Price: $1190
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0026292
Product name: 4-N-BOC-2-METHYL-PIPERAZINE
Purity: 95.00%
Packaging: 25G
Price: $1206.98
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 63256
Product name: 4-N-Boc-2-methylpiperazine
Packaging: 50g
Price: $2200
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0026292
Product name: 4-N-BOC-2-METHYL-PIPERAZINE
Purity: 95.00%
Packaging: 150G
Price: $2816
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140620
Product name: 4-N-Boc-2-methylpiperazine
Packaging: 100g
Price: $350
Updated: 2021/12/16

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4-N-Boc-2-Methyl-piperazine Chemical Properties,Usage,Production

Chemical Properties

Clear Colourless Oil

Uses

4-N-Boc-2-methylpiperazine is a boc protetcted piperazine derivative used in the preparation of prazosin-related compounds with blocking activity toward α-adrenoreceptors.

Synthesis

24424-99-5

109-07-9

120737-59-9

General procedure for the synthesis of 4-tert-butoxycarbonyl-2-methylpiperazine from di-tert-butyl dicarbonate and 2-methylpiperazine: 1) Di-tert-butyl dicarbonate (21.7 g) was slowly added to a solution of 2-methylpiperazine (10.0 g) in methanol (200 mL) at room temperature, followed by continuous stirring of the reaction mixture for 24 hours. Upon completion of the reaction, the methanol solvent was removed by distillation under reduced pressure. The resulting crude product was purified by silica gel column chromatography (eluent: chloroform-methanol mixed solvent) to finally obtain tert-butyl 3-methylpiperazine-1-carboxylate as a colorless oily product (19.3 g, 96.5% yield). The product was characterized by 1H-NMR (300 MHz, CDCl3): δ1.04 (3H, d, J=6.24 Hz), 1.46 (9H, s), 2.39 (1H, br s), 2.70-2.77 (3H, m), 2.94 (1H, br s), 3.93 (2H, br s). Mass spectrometry analysis (FAB) showed the molecular ion peak M/Z: 201 (M+H)+.

References

[1] Patent: US2003/153556, 2003, A1
[2] Patent: EP1621537, 2006, A1. Location in patent: Page/Page column 33
[3] Patent: WO2016/168619, 2016, A1. Location in patent: Paragraph 00286
[4] Patent: EP1548010, 2005, A1. Location in patent: Page/Page column 19
[5] Journal of Medicinal Chemistry, 2016, vol. 59, # 11, p. 5432 - 5448

4-N-Boc-2-Methyl-piperazine Preparation Products And Raw materials

Raw materials

1-Butyl nitrite Di-tert-butyl dicarbonate tert-Butanol Triethylamine 2-Methylpiperazine Chloroform Sodium ethoxide 1,4-Dioxane Benzeneacetonitrile Tetrahydrofuran N,N-Dimethylaniline Benzene Diphosgene Hydrochloric acid Methanol Sodium hydroxide Pyridine

Preparation Products

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4-N-Boc-2-Methyl-piperazine Suppliers

Canada 1 China 125 Europe 2 France 1 Germany 4 Hungary 1 India 3 Japan 1 United Kingdom 13 United States 38 Global 189

Chembon Pharmaceutical Co., Ltd.

Tel: 028-84252981
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J & K SCIENTIFIC LTD.

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Fax: 86-10-82849933
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Tel: +49 3493/605464
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Country: Germany
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Alfa Aesar

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Energy Chemical

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Email: sales@chemwish.com
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Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
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JinYan Chemicals(ShangHai) Co.,Ltd.

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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

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View Lastest Price from 4-N-Boc-2-Methyl-piperazine manufacturers

Career Henan Chemical Co

Product: 4-N-Boc-2-Methyl-piperazine 120737-59-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10 tons
Release date: 2020-01-10

120737-59-9, 4-N-Boc-2-Methyl-piperazineRelated Search:

Butyl acetate Methyl acrylate Methyl salicylate RESMETHRIN tert-Butyldimethylsilyl chloride Tribenuron methyl Piperazine Cyhalofop-butyl Diethylene glycol monobutyl ether Buprofezin METSULFURON METHYL 2-Methylpiperazine 2-Butoxyethanol Methyl acetate 1-Methylpiperazine Kresoxim-methyl BUTYL OLEATE Butyl acrylate

1-Boc-3-methyl-piperazine

N-1-BOC-3-METHYL PIPERIZINE

1-N-Boc-3-methylpiperizine

tert-Butyl 3-methylpiperazine-1-carboxylate

N-1-BOC-3-METHYL PIPERAZINE

(+/-)-N4-BOC-2-METHYLPIPERAZINE

4-N-BOC-2-METHYL-PIPERAZINE

4-BOC-2-METHYL PIPERAZINE

3-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

2-METHYL-4-BOC-PIPERAZINE

2-Methylpiperazine, N4-BOC protected

Boc-3-methylpiperazine

REF DUPL: 4-N-Boc-2-methyl-piperazine

3-Methylpiperazine, N1-BOC protected

tert-butyl 3-Methylpiperazin-1-carboxylate

tert-Butyl 3-methylpiperazine-1-carboxylate, 1-(tert-Butoxycarbonyl)-3-methylpiperazine

N-Boc-3-Methyl-Piperazine

1-Piperazinecarboxylic acid, 3-Methyl-, 1,1-diMethylethyl ester

(^+)-1-Boc-3-methylpiperazine,97%

(+-)-N4-Boc-2-methylpiperazine

1,1-Dimethylethyl 3-methyl-1-piperazinecarboxylate

tert-Butyl 3-methyl-1-piperazinecarboxylate

120737-59-9

pharmacetical

Piperaizine

Acids and Derivatives

Amines and Anilines

Pyrans, Piperidines & Piperazines

Piperazines