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Diphosgene

Product Name
Diphosgene
CAS No.
503-38-8
Chemical Name
Diphosgene
Synonyms
DP;TRICHLOROMETHYL CHLOROFORMATE;ASP-PRO;Difosgen;Perstoff;Diphosgen;DIPHOSGENE;Disphosgene;Diphosgene,99%;perchloromethylformate
CBNumber
CB7332155
Molecular Formula
C2Cl4O2
Formula Weight
197.83
MOL File
503-38-8.mol
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Diphosgene Property

Melting point:
-57 °C
Boiling point:
20 °C10 mm Hg(lit.)
Density 
1.64
refractive index 
n20/D 1.458
Flash point:
>110°C
storage temp. 
2-8°C
solubility 
Chloroform (Soluble), Ethyl Acetate (Sparingly)
form 
Liquid
color 
Clear colorless
Water Solubility 
may decompose
Sensitive 
Moisture Sensitive
Merck 
14,3334
BRN 
970225
Stability:
Hygroscopic, Moisture Sensitive
CAS DataBase Reference
503-38-8(CAS DataBase Reference)
NIST Chemistry Reference
Trichloromethyl chloroformate(503-38-8)
EPA Substance Registry System
Carbonochloridic acid, trichloromethyl ester (503-38-8)
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Safety

Hazard Codes 
T+,Xi
Risk Statements 
26/28-34-26/27/28-36/37/38
Safety Statements 
26-28-36/37/39-45-28A-36
RIDADR 
UN 3277 6.1/PG 2
WGK Germany 
3
RTECS 
LQ7350000
8-10-19
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29159000
Hazardous Substances Data
503-38-8(Hazardous Substances Data)
Toxicity
LC100 in rabbits (10-20 minutes exposure to vapor): 0.9 mg/l air (Klika, Mysliveckova)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H330Fatal if inhaled

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
23261
Product name
Trichloromethyl chloroformate
Purity
≥97.0% (GC)
Packaging
10ml
Price
$135
Updated
2024/03/01
Sigma-Aldrich
Product number
23261
Product name
Trichloromethyl chloroformate
Purity
≥97.0% (GC)
Packaging
50ml
Price
$625
Updated
2024/03/01
Alfa Aesar
Product number
A17444
Product name
Trichloromethyl chloroformate, 98%
Packaging
10g
Price
$53.65
Updated
2024/03/01
Alfa Aesar
Product number
A17444
Product name
Trichloromethyl chloroformate, 98%
Packaging
50g
Price
$229
Updated
2024/03/01
Alfa Aesar
Product number
A17444
Product name
Trichloromethyl chloroformate, 98%
Packaging
250g
Price
$778
Updated
2024/03/01
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Diphosgene Chemical Properties,Usage,Production

Description

Diphosgene (DP), trichloromethyl chloroformate, is a clear, colorless liquid with an odor similar to phosgene. It is noncombustible, a strong irritant to the eyes and tissues, and is toxic by inhalation and ingestion. DP has a boiling point of 127°C–128°C (263°F) and a vapor pressure of 4.2 at 68°F (20°C). The liquid density is 1.65, which is heavier than water, and a melting/freezing point of 314°F (157°C). Inhalation LC50 is 3600 mg/m3 for 10 min. Effects of exposure are quite similar to phosgene gas. Its molecular formula is ClCOOCCl3, and the structure and molecular formula are shown in Figure 8.38. The DOT lists diphosgene as a 6.1 poison liquid. The NFPA 704 designation for CG is estimated to be health 4, flammability 0, reactivity 1, and special 0. It has a four-digit UN identification number of 2972.

Chemical Properties

clear colorless liquid

Uses

Trichloromethyl chloroformate is used as a reagent in the synthesis of organic compounds. It serves as a source of phosgene used in some laboratory preparations. Also, it is used as a reactant for the synthesis of cyclic carbamimidates, N-alkenyl and cycloalkyl carbamates and prostate-specific membrane antigen-targeted anticancer prodrugs. In addition, it is involved in the preparation of an erythromycin A derivatives and antibody-drug conjugates. It is utilized in the conversion of amines, carboxylic acids, formamides in to isocyanates, acid chlorides and isocyanides respectively.

Uses

Reactant for preparation of:

  • Cyclic carbamimidates using a monophosphine gold(i) catalyst
  • N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands
  • Prostate-specific membrane antigen-targeted anticancer prodrugs
  • Potential west nile virus protease inhibitors
  • Antibody-drug conjugates (ADCs)
  • Erythromycin A derivatives

Uses

In organic synthesis; as war gas.

Definition

diphosgene: A colourless liquid,ClCO.O.CCl3, originally used in 1916by Germany in World War I as achemical warfare agent. It is nowused as a reagent in organic synthesis.See also carbonyl chloride.

General Description

Colorless liquid, odorless to fruity.

Air & Water Reactions

Decomposes slowly in water or moist air (or when inhaled) to form very corrosive hydrogen chloride gas (hydrochloric acid) and carbon monoxide.

Hazard

Toxic by inhalation and ingestion, strong irritant to tissue.

Fire Hazard

Some may burn but none ignite readily. Vapors from liquefied gas are initially heavier than air and spread along ground. Some of these materials may react violently with water. Cylinders exposed to fire may vent and release toxic and/or corrosive gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket.

Safety Profile

Low toxicity by inhalation. A corrosive liquid. When heated to decomposition it emits toxic vapors of Cl-.

Diphosgene Preparation Products And Raw materials

Raw materials

Preparation Products

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Diphosgene Suppliers

Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12426
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
Advantage
60
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18736
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9725
Advantage
55
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View Lastest Price from Diphosgene manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
DP
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2021-03-11
Career Henan Chemical Co
Product
Diphosgene 503-38-8
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100KG
Release date
2018-12-17

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