ChemicalBook > CAS DataBase List > Diphosgene

Diphosgene

Product Name: Diphosgene
CAS No.: 503-38-8
Chemical Name: Diphosgene
Synonyms: DP;TRICHLOROMETHYL CHLOROFORMATE;ASP-PRO;Difosgen;Perstoff;Diphosgen;DIPHOSGENE;Disphosgene;Diphosgene,99%;perchloromethylformate
CBNumber: CB7332155
Molecular Formula: C2Cl4O2
Formula Weight: 197.83
MOL File: 503-38-8.mol

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Diphosgene Property

Melting point:: -57 °C
Boiling point:: 20 °C10 mm Hg(lit.)
Density: 1.64
vapor pressure: 13 hPa ( 20 °C)
refractive index: n20/D 1.458
Flash point:: >110°C
storage temp.: 2-8°C
solubility: Chloroform (Soluble), Ethyl Acetate (Sparingly)
form: Liquid
color: Clear colorless
Water Solubility: may decompose
Sensitive: Moisture Sensitive
Merck: 14,3334
BRN: 970225
Stability:: Hygroscopic, Moisture Sensitive
CAS DataBase Reference: 503-38-8(CAS DataBase Reference)
NIST Chemistry Reference: Trichloromethyl chloroformate(503-38-8)
EPA Substance Registry System: Carbonochloridic acid, trichloromethyl ester (503-38-8)

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Safety

Hazard Codes: T+,Xi
Risk Statements: 26/28-34-26/27/28-36/37/38
Safety Statements: 26-28-36/37/39-45-28A-36
RIDADR: UN 3277 6.1/PG 2
WGK Germany: 3
RTECS: LQ7350000
F: 8-10-19
TSCA: Yes
HazardClass: 6.1
PackingGroup: II
HS Code: 29159000
Hazardous Substances Data: 503-38-8(Hazardous Substances Data)
Toxicity: LC100 in rabbits (10-20 minutes exposure to vapor): 0.9 mg/l air (Klika, Mysliveckova)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H330Fatal if inhaled

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 23261
Product name: Trichloromethyl chloroformate
Purity: ≥97.0% (GC)
Packaging: 10ml
Price: $139
Updated: 2025/07/31

Sigma-Aldrich

Product number: 23261
Product name: Trichloromethyl chloroformate
Purity: ≥97.0% (GC)
Packaging: 50ml
Price: $644
Updated: 2025/07/31

TRC

Product number: T773880
Product name: Trichloromethyl chloroformate
Packaging: 25g
Price: $105
Updated: 2021/12/16

Oakwood

Product number: 046973
Product name: Trichloromethyl chloroformate
Purity: 98%
Packaging: 5g
Price: $15
Updated: 2021/12/16

AK Scientific

Product number: Q776
Product name: Trichloromethyl chloroformate
Packaging: 25g
Price: $62
Updated: 2021/12/16

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Diphosgene Chemical Properties,Usage,Production

Description

Diphosgene (DP), trichloromethyl chloroformate, is a clear, colorless liquid with an odor similar to phosgene. It is noncombustible, a strong irritant to the eyes and tissues, and is toxic by inhalation and ingestion. DP has a boiling point of 127°C–128°C (263°F) and a vapor pressure of 4.2 at 68°F (20°C). The liquid density is 1.65, which is heavier than water, and a melting/freezing point of 314°F (157°C). Inhalation LC50 is 3600 mg/m3 for 10 min. Effects of exposure are quite similar to phosgene gas. Its molecular formula is ClCOOCCl3, and the structure and molecular formula are shown in Figure 8.38. The DOT lists diphosgene as a 6.1 poison liquid. The NFPA 704 designation for CG is estimated to be health 4, flammability 0, reactivity 1, and special 0. It has a four-digit UN identification number of 2972.

Chemical Properties

clear colorless liquid

Uses

Trichloromethyl chloroformate is used as a reagent in the synthesis of organic compounds. It serves as a source of phosgene used in some laboratory preparations. Also, it is used as a reactant for the synthesis of cyclic carbamimidates, N-alkenyl and cycloalkyl carbamates and prostate-specific membrane antigen-targeted anticancer prodrugs. In addition, it is involved in the preparation of an erythromycin A derivatives and antibody-drug conjugates. It is utilized in the conversion of amines, carboxylic acids, formamides in to isocyanates, acid chlorides and isocyanides respectively.

Uses

Reactant for preparation of:

Cyclic carbamimidates using a monophosphine gold(i) catalyst
N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands
Prostate-specific membrane antigen-targeted anticancer prodrugs
Potential west nile virus protease inhibitors
Antibody-drug conjugates (ADCs)
Erythromycin A derivatives

Uses

In organic synthesis; as war gas.

Definition

diphosgene: A colourless liquid,ClCO.O.CCl₃, originally used in 1916by Germany in World War I as achemical warfare agent. It is nowused as a reagent in organic synthesis.See also carbonyl chloride.

General Description

Colorless liquid, odorless to fruity.

Air & Water Reactions

Decomposes slowly in water or moist air (or when inhaled) to form very corrosive hydrogen chloride gas (hydrochloric acid) and carbon monoxide.

Hazard

Toxic by inhalation and ingestion, strong irritant to tissue.

Fire Hazard

Some may burn but none ignite readily. Vapors from liquefied gas are initially heavier than air and spread along ground. Some of these materials may react violently with water. Cylinders exposed to fire may vent and release toxic and/or corrosive gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket.

Safety Profile

Low toxicity by inhalation. A corrosive liquid. When heated to decomposition it emits toxic vapors of Cl-.

Diphosgene Preparation Products And Raw materials

Raw materials

Preparation Products

Methidathion Tribenuron methyl 4-FLUOROBENZYL ISOCYANATE Benzyl chloroformate 4-N-Boc-2-Methyl-piperazine

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View Lastest Price from Diphosgene manufacturers

Career Henan Chemical Co

Product: Diphosgene 503-38-8
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-17

503-38-8, DiphosgeneRelated Search:

Cyclohexyl chloroformate Pentyl chloroformate Cyclopentyl chloroformate Allyl chloroformate Isobutyl chloroformate Isopropyl chloroformate HEXYL CHLOROFORMATE 2-Chloroethyl chloroformate 1,1-Dichlorodimethyl ether BIS(CHLOROMETHYL)ETHER Methyl chloroformate Chloromethyl chloroformate Chloroformate Diphosgene TRICHLOROMETHYL CHLOROFORMATE = CHLOROFORMIC ACID TRICHLOROMETHYL ESTER = DIPHOSGENE DIPHOSGENE[100404DH] DIPHOSGENE [CARBONYL-14C]

Carbonochloridicacid,trichloromethylester

Disphosgene

Trichloromethylchloroformate=Diphosgene

Trichloromethylchloroformate,98%

DIPHOSGENE (conmtrolled chemical)

Trichloromethylchloroformate, 97% + 22764 Deposit Required

(Trichloromethoxy)formic acid chloride

Chloridocarbonic acid trichloromethyl ester

Chloroformic acid trichloromethyl

Diphosgene,99%

ASP-PRO

TRICHLOROMETHYL CHLOROFORMATE FOR SYNTHE

TrichloroMethyl chloroforMat

TrichloroMethyl chloroforMate >=97.0% (GC)

Carbonochloridic acid, trichloromethyl ester

carbonochloridicacidtrichloromethylester

chloro-formicacitrichloromethylester

Difosgen

Diphosgen

Formic acid, chloro-, trichloromethyl ester

Methanol, trichloro-, chloroformate

perchloromethylformate

Perstoff

Trichlormethylester kyseliny chlormravenci

trichlormethylesterkyselinychlormravenci

trichloro-methanochloroformate

DIPHOSGENE

CHLOROFORMIC ACID TRICHLOROMETHYL ESTER

TRICHLOROMETHYL CHLOROFORMATE

tianfu-chem_Diphosgene 503-38-8

503-38-8

C2Cl4O2

ClCOOCCl3

ClCO2CCl3

COCl22

Synthetic Reagents

Protection and Derivatization

Others

Deprotection

API Intermediate

Pharmaceutical Intermediates