ChemicalBook > CAS DataBase List > 4-N-Boc-2-Methyl-piperazine

4-N-Boc-2-Methyl-piperazine

Product Name
4-N-Boc-2-Methyl-piperazine
CAS No.
120737-59-9
Chemical Name
4-N-Boc-2-Methyl-piperazine
Synonyms
Boc-3-methylpiperazine;1-Boc-3-methyl-piperazine;2-METHYL-4-BOC-PIPERAZINE;4-BOC-2-METHYL PIPERAZINE;N-Boc-3-Methyl-Piperazine;1-N-Boc-3-methylpiperizine;N-1-BOC-3-METHYL PIPERIZINE;N-1-BOC-3-METHYL PIPERAZINE;4-N-BOC-2-METHYL-PIPERAZINE;(+-)-N4-Boc-2-methylpiperazine
CBNumber
CB8170798
Molecular Formula
C10H20N2O2
Formula Weight
200.28
MOL File
120737-59-9.mol
More
Less

4-N-Boc-2-Methyl-piperazine Property

Boiling point:
268.7±15.0 °C(Predicted)
Density 
0.997±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Chloroform, DMSO, Ethyl Acetate
pka
8.52±0.40(Predicted)
form 
Oil
color 
Clear Colourless
InChI
InChI=1S/C10H20N2O2/c1-8-7-12(6-5-11-8)9(13)14-10(2,3)4/h8,11H,5-7H2,1-4H3
InChIKey
FMLPQHJYUZTHQS-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCNC(C)C1
CAS DataBase Reference
120737-59-9(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi,N
Risk Statements 
36/37/38-50
Safety Statements 
26-36/37/39-61-37
RIDADR 
UN3077
HS Code 
29335990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

TRC
Product number
B656980
Product name
4-N-Boc-2-methylpiperazine
Packaging
50g
Price
$1190
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0026292
Product name
4-N-BOC-2-METHYL-PIPERAZINE
Purity
95.00%
Packaging
25G
Price
$1206.98
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
63256
Product name
4-N-Boc-2-methylpiperazine
Packaging
50g
Price
$2200
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0026292
Product name
4-N-BOC-2-METHYL-PIPERAZINE
Purity
95.00%
Packaging
150G
Price
$2816
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140620
Product name
4-N-Boc-2-methylpiperazine
Packaging
100g
Price
$350
Updated
2021/12/16
More
Less

4-N-Boc-2-Methyl-piperazine Chemical Properties,Usage,Production

Chemical Properties

Clear Colourless Oil

Uses

4-N-Boc-2-methylpiperazine is a boc protetcted piperazine derivative used in the preparation of prazosin-related compounds with blocking activity toward α-adrenoreceptors.

Synthesis

24424-99-5

109-07-9

120737-59-9

General procedure for the synthesis of 4-tert-butoxycarbonyl-2-methylpiperazine from di-tert-butyl dicarbonate and 2-methylpiperazine: 1) Di-tert-butyl dicarbonate (21.7 g) was slowly added to a solution of 2-methylpiperazine (10.0 g) in methanol (200 mL) at room temperature, followed by continuous stirring of the reaction mixture for 24 hours. Upon completion of the reaction, the methanol solvent was removed by distillation under reduced pressure. The resulting crude product was purified by silica gel column chromatography (eluent: chloroform-methanol mixed solvent) to finally obtain tert-butyl 3-methylpiperazine-1-carboxylate as a colorless oily product (19.3 g, 96.5% yield). The product was characterized by 1H-NMR (300 MHz, CDCl3): δ1.04 (3H, d, J=6.24 Hz), 1.46 (9H, s), 2.39 (1H, br s), 2.70-2.77 (3H, m), 2.94 (1H, br s), 3.93 (2H, br s). Mass spectrometry analysis (FAB) showed the molecular ion peak M/Z: 201 (M+H)+.

References

[1] Patent: US2003/153556, 2003, A1
[2] Patent: EP1621537, 2006, A1. Location in patent: Page/Page column 33
[3] Patent: WO2016/168619, 2016, A1. Location in patent: Paragraph 00286
[4] Patent: EP1548010, 2005, A1. Location in patent: Page/Page column 19
[5] Journal of Medicinal Chemistry, 2016, vol. 59, # 11, p. 5432 - 5448

4-N-Boc-2-Methyl-piperazine Preparation Products And Raw materials

Raw materials

1-Butyl nitrite Di-tert-butyl dicarbonate tert-Butanol Triethylamine 2-Methylpiperazine Chloroform Sodium ethoxide 1,4-Dioxane Benzeneacetonitrile Tetrahydrofuran N,N-Dimethylaniline Benzene Diphosgene Hydrochloric acid Methanol Sodium hydroxide Pyridine

Preparation Products

More
Less

4-N-Boc-2-Methyl-piperazine Suppliers

Canada 1 China 125 Europe 2 France 1 Germany 4 Hungary 1 India 3 Japan 1 United Kingdom 13 United States 38 Global 189
Chembon Pharmaceutical Co., Ltd.
Tel
028-84252981
Fax
+86-28-84252965
Email
sales@chembon.com.cn
Country
China
ProdList
850
Advantage
64
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11598
Advantage
64
Sichuan Guanghan Bio-Tech Co., Ltd
Tel
+86-28-86127071
Fax
+86-28-86127072
Email
info@sino-produce.com
Country
China
ProdList
406
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Boc Chemical Co.,Ltd
Tel
021-34975603-808 18721111801
Fax
+86-21-34975602-805
Email
sales@bocpharma.com
Country
China
ProdList
1009
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
ProdList
4267
Advantage
65
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
Chengdu HappySyn Pharmaceutical Technology Co., Ltd.
Tel
028-85114309 18982182443
Email
yangli@happysyn.com
Country
China
ProdList
2150
Advantage
55
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Nanjing Norris-Pharm Technology Co., Ltd
Tel
18652989687
Fax
+86-25-52131256
Email
sales@norris-pharm.com
Country
China
ProdList
8878
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8026
Advantage
55
Huainan Kedi Chemical Factory
Tel
0554-2106669
Fax
0554-2666215
Email
sales1@kedichem.com
Country
China
ProdList
4924
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Porse Fine Chemical Co.,LTD
Tel
20-66003216 18666003216
Fax
+86-20-28069063
Email
info@porsefinechemical.com
Country
China
ProdList
1941
Advantage
62
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9476
Advantage
58
Chengdu Firster Pharmaceutical Co., Ltd.
Tel
028-87078428 028-87074958
Fax
8772-8116
Email
chengzhenyong@cdfirster.com
Country
China
ProdList
2598
Advantage
60
Shanghai AQBioPharma Co., Ltd.
Tel
13661411401
Fax
51370935-8011
Email
yinglv.que@aqbiopharma.com.cn
Country
China
ProdList
2930
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567 18521000990
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6479
Advantage
50
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66028182 18626450290
Email
yftan@aikonchem.com
Country
China
ProdList
16679
Advantage
50
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Hangzhou Milestone Pharmtech Co., Ltd.
Tel
0571-82896630 18969958410
Email
sales_hz@milestonepharmtech.com
Country
China
ProdList
4894
Advantage
55
Shanghai KunRaise Chemical Technology Co., Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
716
Advantage
55
Quzhou Rundong Chemical (Technology) Co.
Tel
0570-8789886 18892685668
Fax
0570-8789985
Email
info@rundongchemical.com
Country
China
ProdList
4053
Advantage
60
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6498
Advantage
58
Shanghai Shanyuan pharmaceutical technology co., LTD
Tel
021-31761238 13167072949
Fax
021-31761238
Email
3146446224@qq.com
Country
China
ProdList
1379
Advantage
55
TaiChem Taizhou Limited
Tel
052386810091
Email
zcwy9518@yeah.net
Country
China
ProdList
3912
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9125
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Guangdong wengjiang Chemical Reagent Co., Ltd.
Tel
0751-2886750 13927877953
Fax
0751-2886750
Email
3005811397@qq.com
Country
China
ProdList
13305
Advantage
58
Nanjing Klender Bio-Technology Co., Ltd.
Tel
025-52343882 18112933882
Fax
025-52343882
Email
sales@kldbio.com
Country
China
ProdList
2019
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799 20）
Fax
0539-6362799（To 20）
Country
China
ProdList
9998
Advantage
58
Hangzhou Molcore Biopharmatech Co.,Ltd
Tel
400-711-5280 86-571-81025280
Fax
86-571-85806285
Email
sales@molcore.com
Country
China
ProdList
9967
Advantage
58
More
Less

View Lastest Price from 4-N-Boc-2-Methyl-piperazine manufacturers

Career Henan Chemical Co
Product
4-N-Boc-2-Methyl-piperazine 120737-59-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10 tons
Release date
2020-01-10

120737-59-9, 4-N-Boc-2-Methyl-piperazineRelated Search:

Butyl acetate Methyl acrylate Methyl salicylate RESMETHRIN tert-Butyldimethylsilyl chloride Tribenuron methyl Piperazine Cyhalofop-butyl Diethylene glycol monobutyl ether Buprofezin METSULFURON METHYL 2-Methylpiperazine 2-Butoxyethanol Methyl acetate 1-Methylpiperazine Kresoxim-methyl BUTYL OLEATE Butyl acrylate

  • 1-Boc-3-methyl-piperazine
  • N-1-BOC-3-METHYL PIPERIZINE
  • 1-N-Boc-3-methylpiperizine
  • tert-Butyl 3-methylpiperazine-1-carboxylate
  • N-1-BOC-3-METHYL PIPERAZINE
  • (+/-)-N4-BOC-2-METHYLPIPERAZINE
  • 4-N-BOC-2-METHYL-PIPERAZINE
  • 4-BOC-2-METHYL PIPERAZINE
  • 3-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • 2-METHYL-4-BOC-PIPERAZINE
  • 2-Methylpiperazine, N4-BOC protected
  • Boc-3-methylpiperazine
  • REF DUPL: 4-N-Boc-2-methyl-piperazine
  • 3-Methylpiperazine, N1-BOC protected
  • tert-butyl 3-Methylpiperazin-1-carboxylate
  • tert-Butyl 3-methylpiperazine-1-carboxylate, 1-(tert-Butoxycarbonyl)-3-methylpiperazine
  • N-Boc-3-Methyl-Piperazine
  • 1-Piperazinecarboxylic acid, 3-Methyl-, 1,1-diMethylethyl ester
  • (^+)-1-Boc-3-methylpiperazine,97%
  • (+-)-N4-Boc-2-methylpiperazine
  • 1,1-Dimethylethyl 3-methyl-1-piperazinecarboxylate
  • tert-Butyl 3-methyl-1-piperazinecarboxylate
  • 120737-59-9
  • pharmacetical
  • Piperaizine
  • Acids and Derivatives
  • Amines and Anilines
  • Pyrans, Piperidines & Piperazines
  • Piperazines