(S)-1-Boc-3-methylpiperazine

Product Name: (S)-1-Boc-3-methylpiperazine
CAS No.: 147081-29-6
Chemical Name: (S)-1-Boc-3-methylpiperazine
Synonyms: tert-butyl (S)-3-methylpiperazine-1-carboxylate;(S)-1-BOC-3-METHYLPIPERAZINE;(S)-TERT-BUTYL 3-METHYLPIPERAZINE-1-CARBOXYLATE;(S)-4-Boc-2-methylpiperazine;4-HYDROXY-7-METHOXYQUINOLINE-2-CARBOXYLIC ACID;4-Hydroxy-7-methoxy-2-quinolinecarboxylic acid;CPD2809-SM;(3S)-3-MethyL;(S)-4-N-BOC-2-METHYL;Sotorasib Impurity 2
CBNumber: CB9458934
Molecular Formula: C10H20N2O2
Formula Weight: 200.28
MOL File: 147081-29-6.mol

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(S)-1-Boc-3-methylpiperazine Property

Melting point:: 40-45 °C
Boiling point:: 268.7±15.0 °C(Predicted)
alpha: -16 º (c=1 in dioxane)
Density: 0.997±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
pka: 8.52±0.40(Predicted)
form: Crystalline Powder
color: White to yellow
optical activity: [α]/D -16±2°, c = 1 in dioxane
Sensitive: Air Sensitive
InChI: InChI=1S/C10H20N2O2/c1-8-7-12(6-5-11-8)9(13)14-10(2,3)4/h8,11H,5-7H2,1-4H3/t8-/m0/s1
InChIKey: FMLPQHJYUZTHQS-QMMMGPOBSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCN[C@@H](C)C1
CAS DataBase Reference: 147081-29-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 37/38-41-34
Safety Statements: 26-39-45-36/37/39
RIDADR: 3259
WGK Germany: 3
F: 10-34
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 63207
Product name: (S)-1-Boc-3-methylpiperazine
Purity: ≥98%
Packaging: 1g
Price: $37.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 63207
Product name: (S)-1-Boc-3-methylpiperazine
Purity: ≥98%
Packaging: 5G
Price: $78.4
Updated: 2025/07/31

TCI Chemical

Product number: D6010
Product name: (S)-1-Boc-3-methylpiperazine
Purity: min. 98.0 %
Packaging: 5G
Price: $47
Updated: 2025/07/31

TCI Chemical

Product number: D6010
Product name: (S)-1-Boc-3-methylpiperazine
Purity: min. 98.0 %
Packaging: 25G
Price: $142
Updated: 2025/07/31

TRC

Product number: B656830
Product name: (S)-4-Boc-2-methylpiperazine
Packaging: 25g
Price: $305
Updated: 2021/12/16

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(S)-1-Boc-3-methylpiperazine Chemical Properties,Usage,Production

Description

(S)-1-Boc-3-methylpiperazine is a hydrophobic compound that is structurally modified from the tetracyclic family of drugs. It has been shown to inhibit tumor cell growth by binding to the oncogene, KRASG12C, and downregulating its expression. This compound also inhibits cancer cell growth through the inhibition of the PI3K/AKT signaling pathway. The pharmacological effects of (S)-1-Boc-3-methylpiperazine are dependent on its ability to bind with high affinity to KRASG12C and inhibit its activity.

Chemical Properties

colorless to yellow liquid

Uses

Laboratory chemicals, Manufacture of substances.

Uses

Reactant involved in the synthesis of biologically activy molecules including:

CCR5 antagonists with anti-HIV-1 activity
Opioid receptor antagonists
Human growth hormone secretagogue receptor antagonists for treatment of obesity
Fatty acid oxidation inhibitors

Uses

(S)-4-Boc-2-methylpiperazine ((S)-1-Boc-3-methylpiperazine) is a reagent used in the synthesis of benzamide peptidomimetic as non-ATP competitive inihbitors.

Synthesis

24424-99-5

74879-18-8

147081-29-6

At 0 °C, (S)-2-methylpiperazine (400 mg) was dissolved in dichloromethane (20 mL) and di-tert-butyl dicarbonate (871 mg) was slowly added. The reaction mixture was stirred at room temperature for 4 hours. Upon completion of the reaction, the reaction was quenched with deionized water (20 mL) followed by extraction with dichloromethane (2 x 40 mL). The organic phases were combined, washed with saturated sodium chloride solution (40 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to afford (S)-4-N-tert-butoxycarbonyl-2-methylpiperazine as a white solid (669 mg, 84% yield).

References

[1] Organic Process Research and Development, 2018, vol. 22, # 8, p. 978 - 990
[2] Patent: US2008/76758, 2008, A1. Location in patent: Page/Page column 88
[3] Patent: WO2008/70740, 2008, A1. Location in patent: Page/Page column 184
[4] Patent: US2005/261310, 2005, A1. Location in patent: Page/Page column 19
[5] Patent: WO2018/109050, 2018, A1. Location in patent: Paragraph 0226-0230; 0234-0236; 0240-0241

(S)-1-Boc-3-methylpiperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-1-Boc-3-methylpiperazine Suppliers

Canada 1 China 273 Europe 2 France 2 Germany 3 India 7 Japan 1 Switzerland 1 United Kingdom 13 United States 51 Global 354

Chengdu Zhongde Jihua Pharmaceutical Technology Co., Ltd

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View Lastest Price from (S)-1-Boc-3-methylpiperazine manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: (S)-tert-Butyl 3-methylpiperazine-1-carboxylate 147081-29-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-10-28

Henan Aochuang Chemical Co.,Ltd.

Product: (S)-4-N-Boc-2-methylpiperazine 147081-29-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

Shanghai UCHEM Inc.

Product: (S)-4-N-Boc-2-methylpiperazine 147081-29-6
Price: US $37.00-788.00/g
Min. Order: 10g
Purity: 0.99
Supply Ability: 25kg
Release date: 2023-12-15

147081-29-6, (S)-1-Boc-3-methylpiperazineRelated Search:

(S)-1-Boc-3-benzylpiperazine (S)-tert-butyl 3-formylpiperidine-1-carboxylate (3S)-3-AMinoazepane-1-carboxylic Acid tert-Butyl Ester (S)-1-N-Boc-3-ethylpiperazine (S)-1-BOC-3-PROPYLPIPERAZINE R-N-4-Boc-N-1-Cbz-2-piperazine carboxylic acid N-4-Boc-2-piperazinecarboxylic acid (S)-1-Boc-3-methylpiperazine 1-BOC-3,5-DIMETHYL-PIPERAZINE t-Butyl(2R,5S)-2,5-dimethylpiperazine-1-carboxylate (R)-4-N-Boc-piperazine-2-carboxylic acid methyl ester (R)-1-BOC-3-(Hydroxymethyl)piperazine (S)-2-tert-Butylcarboxamide-4-tert-butoxycarbonyl piperazine (1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE (S)-1-N-Boc-2-methylpiperazine 4-N-Boc-2-Methyl-piperazine 1-Boc-2-Methylpiperazine (R)-1-Boc-3-methylpiperazine

TERT-BUTYL (S)-3-METHYL-1-PIPERAZINECARBOXYLATE

(S)-TERT-BUTYL 3-METHYLPIPERAZINE-1-CARBOXYLATE

(S)-N4-BOC-2-METHYLPIPERAZINE

(S)-1-TERT-BUTOXYCARBONYL-3-METHYLPIPERAZINE

(S)-1-N-BOC-3-METHYLPIPERAZINE

(S)-3-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

(S)-1-BOC-3-METHYLPIPERAZINE

(S)-4-N-BOC-2-METHYL PIPERAZINE

1-PIPERAZINECARBOXYLIC ACID, 3-METHYL-, 1,1-DIMETHYLETHYL ESTER, (3S)-

tert-butyl (S)-3-methylpiperazine-1-carboxylate

(S)-1-Boc-3-methylpiperazine≥ 99% (HPLC, Chiral purity)

4-BOC-2-(S)-METHYL-PIPERAZINE

(3S)-1-BOC-3-METHYLPIPERAZINE

(S)-3-Methyl-1-Boc-piperazine

(S)-4-N-Boc-2-MethylPiperazinee

4-HYDROXY-7-METHOXYQUINOLINE-2-CARBOXYLIC ACID

(S)-4-N-Boc-2-methylpiperazine (S)-4-N-Boc-2-methyl piperazine

(S)-2-METHYL-1-BOC-PIPERAZINE

(S)-4-Boc-2-methylpiperazine

(S)-2-Methylpiperazine, N4-BOC protected

(S)-3-Methylpiperazine, N1-BOC protected

4-Hydroxy-7-methoxy-2-quinolinecarboxylic acid

(S)-4-N-BOC-2-METHYL

(s)-3-methyl-piperazine-1-carboxylic acid tert-butyl

(S)-4-N-BOC-2-Methylpiperazine-HCl

(3S)-3-Methylpiperazine-1-carboxylic acid tert-butyl ester

tert-Butyl (3S)-3-methylpiperazine-1-carboxylate, (3S)-1-(tert-Butoxycarbonyl)-3-methylpiperazine

(S)-1-Boc-3-Methylpiperazine

(S)-1-Boc-3-Methylpiperazine, 98%+

(3S)-3-Methylpiperazine, N1-BOC protected

Chemdraw8(S)-3-Methyl-piperazine-1-carboxylic acid tert-butyl ester

CPD2809-SM

(3S)-3-MethyL

(S)-4-N-Boc-2-methylpiperazine ISO 9001：2015 REACH

1-Piperazinecarboxylic acid, 3-methyl-, 1,1-dimethylethyl ester, (3S)- (9CI, ACI)

3-methyl-1-Piperazinecarboxylic acid 1,1-dimethylethyl ester (3S)- (9CI ACI)

3-Methyl-1-piperazinecarboxylic acid tert-butyl ester (3S)-

Sotorasib Impurity 2

(S)-1-Boc-3-methylpiperazine

(S)-4-N-tert-Butyloxycarbonyl-2-methylpiperazine

147081-29-6

Asymmetric Synthesis

Chiral Building Blocks

Heterocyclic Building Blocks

Piperazines

pharmacetical

Piperazine series

Quinoline series

Piperaizine

147081-29-6