ChemicalBook > CAS DataBase List > (R)-1-BOC-3-(Hydroxymethyl)piperazine

(R)-1-BOC-3-(Hydroxymethyl)piperazine

Product Name
(R)-1-BOC-3-(Hydroxymethyl)piperazine
CAS No.
278788-66-2
Chemical Name
(R)-1-BOC-3-(Hydroxymethyl)piperazine
Synonyms
tert-butyl (R)-3-(hydroxymethyl)piperazine-1-carboxylate;(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate;tert-butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate;tert-Butyl (3R)-3-(hydroxymethyl)-1-piperazinecarboxylate;H57159;(3R)-3-(hydroxymethyL;PIPERAZINE-1-CARBOXYLIC;(R)-4-N-Boc-2-hydroxyMeth...;(3R)-3-(Hydroxymethyl)piperazine;(R)-4-Boc-2-hydroxymethyl-piperazine
CBNumber
CB9715509
Molecular Formula
C10H20N2O3
Formula Weight
216.28
MOL File
278788-66-2.mol
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(R)-1-BOC-3-(Hydroxymethyl)piperazine Property

Melting point:
68-70°C
Boiling point:
322.9±22.0 °C(Predicted)
Density 
1.085±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
14.97±0.10(Predicted)
color 
White to Off-White
InChI
InChI=1S/C10H20N2O3/c1-10(2,3)15-9(14)12-5-4-11-8(6-12)7-13/h8,11,13H,4-7H2,1-3H3/t8-/m1/s1
InChIKey
NSILYQWHARROMG-MRVPVSSYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCN[C@@H](CO)C1
CAS DataBase Reference
278788-66-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
41-52
Safety Statements 
26-39
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SYX00408
Product name
(R)-1-BOC-3-(Hydroxymethyl)piperazine
Packaging
1g
Price
$461
Updated
2024/03/01
ChemScene
Product number
CS-D0659
Product name
(R)-1-Boc-3-hydroxymethyl-piperazine
Purity
99.81%
Packaging
1g
Price
$25
Updated
2021/12/16
Apolloscientific
Product number
OR308071
Product name
(3R)-3-(Hydroxymethyl)piperazine,N1-BOCprotected
Purity
99%
Packaging
1g
Price
$38
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB151258
Product name
(R)-4-N-Boc-2-hydroxymethyl-piperazine
Packaging
100mg
Price
$59
Updated
2021/12/16
SynQuest Laboratories
Product number
4H51-1-1R
Product name
(3R)-3-(Hydroxymethyl)piperazine, N1-Boc protected
Packaging
1g
Price
$77
Updated
2021/12/16
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(R)-1-BOC-3-(Hydroxymethyl)piperazine Chemical Properties,Usage,Production

Uses

(R)-1-Boc-3-hydroxymethylpiperazine is a used as a building block for the preparation of PI3K inhibitors for rheumatoid arthritis treatment,benzoxaborole derivatives as antimalarial agents and anti-tuberculosis agents.

Synthesis

1,4-bis-Boc-2-hydroxymethylpiperazine (13.9 kg) and 95% ethanol (30 kg) were added to the reactor, followed by the addition of an aqueous solution (water 21 kg) of configured sodium hydroxide (3.5 kg). The reaction mixture was then heated to reflux. Once the reaction was completed, ethanol was concentrated under reduced pressure. Subsequently, 30 kg of dichloromethane was added and the mixture was separated into liquid and aqueous phases. The aqueous phase was extracted three times with 3 × 20 kg of dichloromethane, and the organic phases were combined. The resulting solution was washed once with 40 kg of a 15% aqueous sodium chloride solution and dried with anhydrous sodium sulfate. Further purification was carried out to obtain (R)-1-BOC-3-(Hydroxymethyl)piperazine.

(R)-1-BOC-3-(Hydroxymethyl)piperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-1-BOC-3-(Hydroxymethyl)piperazine Suppliers

Chengdu Firster Pharmaceutical Co., Ltd.
Tel
028-87078428 028-87074958
Fax
8772-8116
Email
chengzhenyong@cdfirster.com
Country
China
ProdList
2677
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60
Shanghai Jizhi Biochemical Technology Co. Ltd.
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4009004166/18616739031 18616739031
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3007523370@qq.com
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China
ProdList
52693
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Sichuan Lancent Medical Devices Co., Ltd.
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18111675298
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-
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stochem@aliyun.com
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China
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Chengdu Aminotp Pharmaceutical Technology Co.,Ltd.
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028-85755578 18140172005
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028-85755578
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sales@aminotp.com
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China
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Jinan Kabotang Biological Technology Co.,Ltd.
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0531-61320525 15866703830
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495745175@qq.com
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China
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7990
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
ProdList
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Chembest Research Laboratories Limited
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+86-21-20908456
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021-58180499
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sales@BioChemBest.com
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China
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ForeChem (Nantong) Technology Co.,Ltd.
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513-85982855 18921614129
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051385915507
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sales@xianxingpharm.com
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China
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2011
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Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
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sales@chemwish.com
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China
ProdList
35896
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Changzhou Huanling Chemical Co., Ltd.
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0519-89803565 13776850645
Fax
0519-89803575
Email
info4@huanlingchem.com
Country
China
ProdList
641
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View Lastest Price from (R)-1-BOC-3-(Hydroxymethyl)piperazine manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd
Product
(R)-1-BOC-3-(Hydroxymethyl)piperazine 278788-66-2
Price
US $98.00-990.00/g
Min. Order
5g
Purity
98%
Supply Ability
50
Release date
2024-07-12
Career Henan Chemical Co
Product
(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 278788-66-2
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-08-05

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