(R)-N-Boc-piperazine-2-carboxylic acid methyl ester

Product Name: (R)-N-Boc-piperazine-2-carboxylic acid methyl ester
CAS No.: 252990-05-9
Chemical Name: (R)-N-Boc-piperazine-2-carboxylic acid methyl ester
Synonyms: Piperazine-1,2-dicarboxylic acid;[(2-N-BOC)PIPERAZINE(2R)COOH]-OME;1-tert-butyl ester 2-methyl ester;(R)-1-N-Boc-piperazine-2-carboxylic;(R)-N-Boc-piperazine-2-carboxylic acid;Methyl (R)-1-Boc-piperazine-2-carboxylate;Methyl (R)-1-N-Boc-piperazine-2-carboxylate;(R)-N-Boc-piperazine-2-carboxylic acid methyl ester;(R)-1--Boc-Piperazine-2-carboxylic acid methyl ester;(R)-1-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER
CBNumber: CB0123905
Molecular Formula: C11H20N2O4
Formula Weight: 244.29
MOL File: 252990-05-9.mol

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(R)-N-Boc-piperazine-2-carboxylic acid methyl ester Property

Boiling point:: 321.3±37.0 °C(Predicted)
Density: 1.118±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 7.25±0.40(Predicted)
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C11H20N2O4/c1-11(2,3)17-10(15)13-6-5-12-7-8(13)9(14)16-4/h8,12H,5-7H2,1-4H3/t8-/m1/s1
InChIKey: BRXKHIPPSTYCKO-MRVPVSSYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCNC[C@@H]1C(OC)=O
CAS DataBase Reference: 252990-05-9(CAS DataBase Reference)

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Usbiological

Product number: 285573
Product name: R)-1-N-Boc-piperazine-2-carboxylic acid methyl ester
Packaging: 25g
Price: $1919
Updated: 2021/12/16

AK Scientific

Product number: J50370
Product name: Methyl(R)-1-Boc-piperazine-2-carboxylate
Packaging: 1g
Price: $100
Updated: 2021/12/16

Activate Scientific

Product number: AS3114
Product name: Methyl (R)-1-N-Boc-piperazine-2-carboxylate
Purity: 95+% ee
Packaging: 1g
Price: $152
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-R02
Product name: 1-tert-Butyl 2-methyl (2R)-piperazine-1,2-dicarboxylate
Packaging: 1g
Price: $188
Updated: 2021/12/16

Activate Scientific

Product number: AS3114
Product name: Methyl (R)-1-N-Boc-piperazine-2-carboxylate
Purity: 95+% ee
Packaging: 5G
Price: $461
Updated: 2021/12/16

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(R)-N-Boc-piperazine-2-carboxylic acid methyl ester Chemical Properties,Usage,Production

Synthesis

278788-60-6

18107-18-1

252990-05-9

Trimethylsilylated diazomethane (2 M solution in hexane, 14 mL) was slowly added dropwise to a mixture of (R)-N-Boc-2-piperazinecarboxylic acid (5 g) dissolved in methanol (100 mL) and dichloromethane (115 mL). The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue obtained was purified by column chromatography, first using ethyl acetate as eluent and subsequently using a solution of ethyl acetate containing 5% methanol and 7N ammonia as eluent to afford methyl (R)-1-Boc-2-piperazinecarboxylate as an oil (2.55 g, 48% yield). NMR hydrogen spectrum (DMSO-d6) δ 1.40 (s, 9H), 2.10 (bs, 1H), 2.52 (m, 1H), 2.72 (dd, 1H), 2.82 (d, 1H), 2.97 (m, 1H), 3.29 (d, 1H), 3.61 (d, 1H), 3.67 (s, 3H), 4.43 (m, 1H); mass spectrum showed the molecular ion peak MH+ 245.

References

[1] Patent: WO2005/26152, 2005, A1. Location in patent: Page/Page column 136

(R)-N-Boc-piperazine-2-carboxylic acid methyl ester Preparation Products And Raw materials

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View Lastest Price from (R)-N-Boc-piperazine-2-carboxylic acid methyl ester manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: (R)-N-Boc-piperazine-2-carboxylic acid methyl ester 252990-05-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-10

Career Henan Chemical Co

Product: (R)-N-Boc-piperazine-2-carboxylic acid methyl ester 252990-05-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-03

252990-05-9, (R)-N-Boc-piperazine-2-carboxylic acid methyl esterRelated Search:

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(R)-Piperazine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (R)-1-Boc-piperazine-2-carboxylic acid methyl ester

[(2-N-BOC)PIPERAZINE(2R)COOH]-OME

(R)-PIPERAZINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER

(R)-1-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER

(R)-1-TERT-BUTYL 2-METHYL PIPERAZINE-1,2-DICARBOXYLATE

(R)-N-Boc-piperazine-2-carboxylic acid methyl ester

(R)-1--Boc-Piperazine-2-carboxylic acid methyl ester

Methyl (R)-1-Boc-piperazine-2-carboxylate

(R)-1-N-Boc-piperazine-2-carboxylic

1-tert-Butyl 2-methyl (2R)-piperazine-1,2-dicarboxylate 97%

(R)-N-Boc-piperazine-2-carboxylic acid

Piperazine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

REF DUPL: (R)-1-N-Boc-piperazine-2-carboxylic acid methyl ester

1-tert-butyl ester 2-methyl ester

Piperazine-1,2-dicarboxylic acid

(R)-1-N-Boc-Piperazine-2-carboxylic acid Methyl ester 98%

1-tert-butyl 2-Methyl (2R)-piperazine-1,2-dicarboxylate

1,2-Piperazinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-methyl ester, (2R)-

1-(tert-butyl) 2-methyl (R)-piperazine-1,2-dicarboxylate

1-O-tert-butyl 2-O-methyl (2R)-piperazine-1,2-dicarboxylate

(R)-N-Boc-piperazine-2-carboxylic acid methyl ester USP/EP/BP

Methyl (R)-1-N-Boc-piperazine-2-carboxylate

1-(1,1-Dimethylethyl) 2-methyl (2R)-1,2-piperazinedicarboxylate

(R)-1-N-Boc-piperazine-2-carboxylic acid methyl ester, 95%min

252990-05-9

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