Methyl 2-iodobenzoate
- Product Name
- Methyl 2-iodobenzoate
- CAS No.
- 610-97-9
- Chemical Name
- Methyl 2-iodobenzoate
- Synonyms
- IBM;2-Iodobenzoate;2-Iodo Methyl Benzoate;methyl iodobenzoate;Methy1;O-Methyl iodide;Methyl 2-iodobenzo;RARECHEM AL BF 0562;Methyl-2-iodbenzoat;METHYL 2-IODOBENZOATE
- CBNumber
- CB5468414
- Molecular Formula
- C8H7IO2
- Formula Weight
- 262.04
- MOL File
- 610-97-9.mol
Methyl 2-iodobenzoate Property
- Melting point:
- 64°C
- Boiling point:
- 149-150 °C/10 mmHg (lit.)
- Density
- 1.784 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.604(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform, Ethyl Acetate (Slightly), Methanol
- form
- Crystalling or Flaky Powder
- color
- White
- Water Solubility
- INSOLUBLE
- Sensitive
- Light Sensitive
- BRN
- 2206859
- Stability:
- Light Sensitive
- InChIKey
- BXXLTVBTDZXPTN-UHFFFAOYSA-N
- CAS DataBase Reference
- 610-97-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Methyl-2-iodobenzoate(610-97-9)
- EPA Substance Registry System
- Benzoic acid, 2-iodo-, methyl ester (610-97-9)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-24/25
- WGK Germany
- 3
- TSCA
- T
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 532851
- Product name
- Methyl 2-iodobenzoate
- Purity
- 97%
- Packaging
- 50g
- Price
- $83.1
- Updated
- 2025/07/31
- Product number
- 532851
- Product name
- Methyl 2-iodobenzoate
- Purity
- 97%
- Packaging
- 250g
- Price
- $185
- Updated
- 2023/06/20
- Product number
- I0586
- Product name
- Methyl 2-Iodobenzoate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $50
- Updated
- 2025/07/31
- Product number
- I0586
- Product name
- Methyl 2-Iodobenzoate
- Purity
- >98.0%(GC)
- Packaging
- 250g
- Price
- $196
- Updated
- 2025/07/31
- Product number
- M313675
- Product name
- Methyl 2-iodobenzoate
- Packaging
- 250g
- Price
- $310
- Updated
- 2021/12/16
Methyl 2-iodobenzoate Chemical Properties,Usage,Production
Chemical Properties
CLEAR YELLOW LIQUID
Uses
Methyl 2-iodobenzoate may be used in the preparation of:
- N-substituted 4-methylene-3,4-dihydro-1(2H)-isoquinolin-1-ones
- methyl diphenylacetylene-2-carboxylate
- methyl 2-heptynylphenylbenzoate
- (E)-2-[3-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-oxopropyl]benzoic acid methyl ester
- 4-(2-carbomethoxyphenyl)-3-(1-methylethoxy)cyclobut-3-ene-1,2-dione
- 3-(2-carbomethoxyphenyl)-4-methylcyclobuten-3-ene-1,2-dione 2-(ethylene acetal)
Synthesis Reference(s)
Journal of the American Chemical Society, 93, p. 4845, 1971 DOI: 10.1021/ja00748a030
General Description
Methyl 2-iodobenzoate can be prepared from 2-iodobenzoic acid via esterification. It undergoes cobalt-catalyzed cyclization with aldehydes to form phthalide derivatives. The microbial dihydroxylation of methyl 2-iodobenzoate forms a nonracemic iodocyclohexene carboxylate intermediate. This intermediate forms the precursor for preparing kibdelone C.
Synthesis
67-56-1
88-67-5
610-97-9
To a 200 mL methanol solution of 2-iodobenzoic acid (15 g, 60 mmol) was slowly added 8.8 mL of concentrated sulfuric acid dropwise. The reaction mixture was heated to reflux for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated by rotary evaporator to about 20 mL. Subsequently, the concentrate was partitioned between water (appropriate amount) and dichloromethane (appropriate amount). The aqueous phase was further extracted with dichloromethane (2 × 150 mL). The organic layers were combined and washed sequentially with saturated sodium bicarbonate solution (3 × 100 mL) and water (3 × 100 mL). The organic layers were dried over anhydrous sodium sulfate, filtered and the solvent was evaporated to give methyl 2-iodobenzoate (47) as a light yellow oil (15.4 g, 98% yield).The infrared spectrum of methyl 2-iodobenzoate (47) (KBr, νmax, cm?1): 3444, 3057, 2994, 2946, 2894, 2836, 1728, 1579, 1459, 1428, 1290. 1459, 1428, 1290, 1249, 1127, 1100, 1013, 738.
References
[1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 17, p. 3213 - 3219
[2] Organometallics, 2013, vol. 32, # 11, p. 3220 - 3226
[3] European Journal of Medicinal Chemistry, 2013, vol. 69, p. 798 - 816
[4] Synthetic Communications, 2017, vol. 47, # 12, p. 1175 - 1184
[5] Angewandte Chemie - International Edition, 2017, vol. 56, # 39, p. 11995 - 11999
Methyl 2-iodobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 2-iodobenzoate manufacturers
- Product
- Methyl 2-Iodobenzoate 610-97-9
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-05
- Product
- Methyl 2-iodobenzoate 610-97-9
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-24
- Product
- Methyl 2-iodobenzoate 610-97-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-09