(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester
- Product Name
- (S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester
- CAS No.
- 314741-39-4
- Chemical Name
- (S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester
- Synonyms
- (S)-4-Boc-piperazine-2-carboxylic a;Methyl (S)-4-Boc-piperazine-2-carboxylate;S-1-Boc-piperazine-3-carboxylic acid Methyl ester;(S)-N-Boc-3-piperazinecarboxylic acid Methyl ester;(S)-tert-butyl methyl piperazine-1,3-dicarboxylate;(S)-4-Boc-Piperazine-2-carboxylic acid methyl ester;(S)-N4-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER;(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester;(S)-1-N-Boc-piperazine-3-carboxylic acid methyl ester;(S)-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL EASTER
- CBNumber
- CB2947844
- Molecular Formula
- C11H20N2O4
- Formula Weight
- 244.29
- MOL File
- 314741-39-4.mol
(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester Property
- Boiling point:
- 321.3±37.0 °C(Predicted)
- Density
- 1.118±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 6.45±0.40(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C11H20N2O4/c1-11(2,3)17-10(15)13-6-5-12-8(7-13)9(14)16-4/h8,12H,5-7H2,1-4H3/t8-/m0/s1
- InChIKey
- QUKAHFCVKNRRBU-QMMMGPOBSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCN[C@H](C(OC)=O)C1
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H228Flammable solid
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
N-Bromosuccinimide Price
- Product number
- M294208
- Product name
- Methyl(S)-4-Boc-piperazine-2-carboxylate
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- OR308068
- Product name
- 1-tert-Butyl3-methyl(3S)-piperazine-1,3-dicarboxylate
- Packaging
- 1g
- Price
- $27
- Updated
- 2021/12/16
- Product number
- 4H58-1-SU
- Product name
- 1-tert-Butyl 3-methyl (3S)-piperazine-1,3-dicarboxylate
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- FB139850
- Product name
- (S)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- AS3118
- Product name
- Methyl (S)-1-N-Boc-piperazine-3-carboxylate
- Purity
- 97+% ee
- Packaging
- 1g
- Price
- $56
- Updated
- 2021/12/16
(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester Chemical Properties,Usage,Production
Synthesis
314741-38-3
314741-39-4
Step 3: Synthesis of 3-tert-butyl 3-methyl(S)-piperazine dicarboxylate (AA3); 10% Pd-C (0.2 eq.) was added to a stirred methanolic solution (0.1 M) of AA 2 at room temperature. The reaction mixture was placed under hydrogen atmosphere and stirred at room temperature for 3 hours. After completion of the reaction, the mixture was filtered and the filter cake was washed with methanol. The filtrate was concentrated under reduced pressure to afford the target product methyl (S)-1-N-Boc-3-piperazinecarboxylate in 89% yield. The product was confirmed by 1H NMR (400 MHz, CDCl3,300K): δ 4.05 (1H, m), 3.76 (3H, s), 3.74-3.68 (1H, m), 3.44 (1H, dd, J = 8.6,3.5 Hz), 3.30-3.12 (1H, m), 3.10-3.00 (2H, m), 2.75 ( 1H, m), 2.17-1.74 (1H, m), 1.47 (9H, s). Mass spectrometry analysis (ES +) showed that the theoretical molecular weight of C11H20N2O4 was 244 and the measured value was 267 (M + Na)+.
References
[1] Patent: WO2010/23480, 2010, A1. Location in patent: Page/Page column 41
[2] Patent: US2003/203917, 2003, A1
[3] Patent: EP1187828, 2004, B1. Location in patent: Page 12
(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester manufacturers
- Product
- (S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester 314741-39-4
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-08-08