ChemicalBook > CAS DataBase List > (S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester

(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester

Product Name
(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester
CAS No.
314741-39-4
Chemical Name
(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester
Synonyms
(S)-4-Boc-piperazine-2-carboxylic a;Methyl (S)-4-Boc-piperazine-2-carboxylate;S-1-Boc-piperazine-3-carboxylic acid Methyl ester;(S)-N-Boc-3-piperazinecarboxylic acid Methyl ester;(S)-tert-butyl methyl piperazine-1,3-dicarboxylate;(S)-4-Boc-Piperazine-2-carboxylic acid methyl ester;(S)-N4-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER;(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester;(S)-1-N-Boc-piperazine-3-carboxylic acid methyl ester;(S)-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL EASTER
CBNumber
CB2947844
Molecular Formula
C11H20N2O4
Formula Weight
244.29
MOL File
314741-39-4.mol
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(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester Property

Boiling point:
321.3±37.0 °C(Predicted)
Density 
1.118±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
6.45±0.40(Predicted)
Appearance
Off-white to light yellow Solid
InChI
InChI=1S/C11H20N2O4/c1-11(2,3)17-10(15)13-6-5-12-8(7-13)9(14)16-4/h8,12H,5-7H2,1-4H3/t8-/m0/s1
InChIKey
QUKAHFCVKNRRBU-QMMMGPOBSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCN[C@H](C(OC)=O)C1
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H228Flammable solid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

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N-Bromosuccinimide Price

TRC
Product number
M294208
Product name
Methyl(S)-4-Boc-piperazine-2-carboxylate
Packaging
250mg
Price
$55
Updated
2021/12/16
Activate Scientific
Product number
AS3118
Product name
Methyl (S)-1-N-Boc-piperazine-3-carboxylate
Purity
97+% ee
Packaging
1g
Price
$56
Updated
2021/12/16
Apolloscientific
Product number
OR308068
Product name
1-tert-Butyl3-methyl(3S)-piperazine-1,3-dicarboxylate
Packaging
1g
Price
$27
Updated
2021/12/16
AK Scientific
Product number
W5348
Product name
Methyl(S)-4-Boc-piperazine-2-carboxylate
Packaging
1g
Price
$84
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB139850
Product name
(S)-1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate
Packaging
500mg
Price
$90
Updated
2021/12/16
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(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester Chemical Properties,Usage,Production

Synthesis

314741-38-3

314741-39-4

Step 3: Synthesis of 3-tert-butyl 3-methyl(S)-piperazine dicarboxylate (AA3); 10% Pd-C (0.2 eq.) was added to a stirred methanolic solution (0.1 M) of AA 2 at room temperature. The reaction mixture was placed under hydrogen atmosphere and stirred at room temperature for 3 hours. After completion of the reaction, the mixture was filtered and the filter cake was washed with methanol. The filtrate was concentrated under reduced pressure to afford the target product methyl (S)-1-N-Boc-3-piperazinecarboxylate in 89% yield. The product was confirmed by 1H NMR (400 MHz, CDCl3,300K): δ 4.05 (1H, m), 3.76 (3H, s), 3.74-3.68 (1H, m), 3.44 (1H, dd, J = 8.6,3.5 Hz), 3.30-3.12 (1H, m), 3.10-3.00 (2H, m), 2.75 ( 1H, m), 2.17-1.74 (1H, m), 1.47 (9H, s). Mass spectrometry analysis (ES +) showed that the theoretical molecular weight of C11H20N2O4 was 244 and the measured value was 267 (M + Na)+.

References

[1] Patent: WO2010/23480, 2010, A1. Location in patent: Page/Page column 41
[2] Patent: US2003/203917, 2003, A1
[3] Patent: EP1187828, 2004, B1. Location in patent: Page 12

(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester manufacturers

Career Henan Chemical Co
Product
(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester 314741-39-4
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-08-08

314741-39-4, (S)-4-N-Boc-piperazine-2-carboxylic acid methyl esterRelated Search:

4-Boc-piperazine-2-carboxylic acid (S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester (R)-4-N-Boc-piperazine-2-carboxylic acid methyl ester N-Boc-piperazine-2-carboxylic acid methyl ester (R)-N-Boc-piperazine-2-carboxylic acid methyl ester N-4-Boc-2-piperazinecarboxylic acid (S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester 3-[[(1,1-Dimethylethoxy)carbonyl]amino]-L-alanine methyl ester METHYL 4-BOC-PIPERAZINE-2-CARBOXYLATE 3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (S)-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID (S)-1-Boc-3-hydroxymethyl-piperazine (S)-Piperazine-2-carboxylic acid (R)-1-Boc-3-methylpiperazine 2-Piperazinecarboxylic acid methyl ester 2-Piperazinecarboxylicacid,methylester,(S)-(9CI) (S)-PIPERAZINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER HCL 1-Piperazinecarboxaldehyde,3-methyl-,(3R)-(9CI)

  • (S)-1-N-Boc-piperazine-3-carboxylic acid methyl ester
  • (S)-N4-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER
  • (S)-4-Boc-Piperazine-2-carboxylic acid methyl ester
  • Methyl (S)-4-Boc-piperazine-2-carboxylate
  • (S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester
  • REF DUPL: (S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester
  • (S)-4-Boc-piperazine-2-carboxylic a
  • 1-tert-butyl 3-methyl (3R)-piperazine-1,3-dicarboxylate
  • 1-tert-butyl 3-methyl (3S)-piperazine-1,3-dicarboxylate
  • 1,3-Piperazinedicarboxylic acid, 1-(1,1-diMethylethyl) 3-Methyl ester, (3S)-
  • S-1-Boc-piperazine-3-carboxylic acid Methyl ester
  • (S)-N-Boc-3-piperazinecarboxylic acid Methyl ester
  • 1-(tert-butyl) 3-methyl (S)-piperazine-1,3-dicarboxylate
  • 1-O-tert-butyl 3-O-methyl (3S)-piperazine-1,3-dicarboxylate
  • (S)-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL EASTER
  • (S)-tert-butyl methyl piperazine-1,3-dicarboxylate
  • 314741-39-4
  • Piperaizine