(S)-1-Boc-3-hydroxymethyl-piperazine
- Product Name
- (S)-1-Boc-3-hydroxymethyl-piperazine
- CAS No.
- 314741-40-7
- Chemical Name
- (S)-1-Boc-3-hydroxymethyl-piperazine
- Synonyms
- tert-butyl (S)-3-(hydroxymethyl)piperazine-1-carboxylate;H57160;TL8002412;NSILYQWHARROMG-QMMMGPOBSA-N;(S)-4-N-Boc-2-hydroxyMeth...;(3S)-3-(Hydroxymethyl)piperazine;(S)-1-Boc-3-(hyroxyMethyl)piperazine;(S)-1-Boc-3-hydroxymethyl-piperazine;(S)-4-Boc-2-(Hydroxymethyl)piperazine;(3S)-1-Boc-3-(hydroxyMethyl)-piperazine
- CBNumber
- CB0947688
- Molecular Formula
- C10H20N2O3
- Formula Weight
- 216.28
- MOL File
- 314741-40-7.mol
(S)-1-Boc-3-hydroxymethyl-piperazine Property
- Boiling point:
- 322.9±22.0 °C(Predicted)
- Density
- 1.085±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 14.97±0.10(Predicted)
- CAS DataBase Reference
- 314741-40-7
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H320Causes eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
N-Bromosuccinimide Price
- Product number
- B600450
- Product name
- (S)-1-Boc-3-hydroxymethyl-piperazine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- AS3142
- Product name
- (S)-1-Boc-(3-hydroxymethyl)piperazine
- Purity
- 98% ee
- Packaging
- 1g
- Price
- $91
- Updated
- 2021/12/16
- Product number
- FB151259
- Product name
- (S)-4-N-Boc-2-hydroxymethyl-piperazine
- Packaging
- 100mg
- Price
- $51
- Updated
- 2021/12/16
- Product number
- CS-D0660
- Product name
- (S)-1-Boc-3-hydroxymethyl-piperazine
- Purity
- >98.0%
- Packaging
- 1g
- Price
- $54
- Updated
- 2021/12/16
- Product number
- CS-D0660
- Product name
- (S)-1-Boc-3-hydroxymethyl-piperazine
- Purity
- >98.0%
- Packaging
- 5g
- Price
- $155
- Updated
- 2021/12/16
(S)-1-Boc-3-hydroxymethyl-piperazine Chemical Properties,Usage,Production
Definition
(S)-1-Boc-3-hydroxymethyl-piperazine is also known as (S)-4-N-Boc-2-(hydroxymethyl)piperazine or (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate.
Uses
(S)-4-N-Boc-2-(hydroxymethyl)piperazine is a useful research chemical.
Synthesis
To synthesize (S)-1-Boc-3-hydroxymethyl-piperazine, a stirred suspension of (S)-piperazine-l,3-dicarboxylic acid l-tert-buty ester (5.00 g, 21.7 mmol) in THF (40 mL) was prepared. Slowly, 1.0 M borane-THF complex solution (32.6 mL, 32.6 mmol) was added to the suspension. The reaction mixture was heated to 90 ℃ and stirred under reflux for 2 h. Before further proceeding, the mixture was removed from heat and an additional 1.5 equivalents of 1.0 M borane-THF complex solution (32.6 mL, 32.6 mmol) was added. The reaction was then reheated and stirred under reflux for 2 h. Subsequently, the reaction mixture was cooled to 0 ℃ and quenched by slowly adding methanol. The resulting mixture was concentrated under reduced pressure, yielding a white solid. This solid was dissolved in THF (30 mL) and cooled to 0 ℃. Slowly, a 2.0 M solution of lithium aluminum hydride (LiAlH4) in THF (27 mL, 54.0 mmol) was added. The reaction was heated to 90 ℃ and stirred under reflux for 2 h. Another portion of 2.0 M LiAlH4 was added, and the reaction mixture was stirred under reflux for 4 hours, followed by overnight stirring at RT. The reaction mixture was then cooled to 0 ℃ and quenched by slowly adding 1.0 M aqueous sodium hydroxide (NaOH) solution until the exothermic reaction subsided. The product (S)-1-Boc-3-hydroxymethyl-piperazine was obtained after purification.
(S)-1-Boc-3-hydroxymethyl-piperazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-1-Boc-3-hydroxymethyl-piperazine manufacturers
- Product
- (S)-4-N-Boc-2-(hydroxymethyl)piperazine 314741-40-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500kg
- Release date
- 2018-08-19