ChemicalBook > CAS DataBase List > (R)-1-BOC-3-(Hydroxymethyl)piperazine
(R)-1-BOC-3-(Hydroxymethyl)piperazine
- Product Name
- (R)-1-BOC-3-(Hydroxymethyl)piperazine
- CAS No.
- 278788-66-2
- Chemical Name
- (R)-1-BOC-3-(Hydroxymethyl)piperazine
- Synonyms
- tert-butyl (R)-3-(hydroxymethyl)piperazine-1-carboxylate;(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate;tert-butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate;tert-Butyl (3R)-3-(hydroxymethyl)-1-piperazinecarboxylate;H57159;(3R)-3-(hydroxymethyL;PIPERAZINE-1-CARBOXYLIC;(R)-4-N-Boc-2-hydroxyMeth...;(3R)-3-(Hydroxymethyl)piperazine;(R)-4-Boc-2-hydroxymethyl-piperazine
- CBNumber
- CB9715509
- Molecular Formula
- C10H20N2O3
- Formula Weight
- 216.28
- MOL File
- 278788-66-2.mol
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(R)-1-BOC-3-(Hydroxymethyl)piperazine Property
- Melting point:
- 68-70°C
- Boiling point:
- 322.9±22.0 °C(Predicted)
- Density
- 1.085±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 14.97±0.10(Predicted)
- color
- White to Off-White
- InChI
- InChI=1S/C10H20N2O3/c1-10(2,3)15-9(14)12-5-4-11-8(6-12)7-13/h8,11,13H,4-7H2,1-3H3/t8-/m1/s1
- InChIKey
- NSILYQWHARROMG-MRVPVSSYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCN[C@@H](CO)C1
- CAS DataBase Reference
- 278788-66-2(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SYX00408
- Product name
- (R)-1-BOC-3-(Hydroxymethyl)piperazine
- Packaging
- 1g
- Price
- $461
- Updated
- 2024/03/01
Activate Scientific
- Product number
- AS3141
- Product name
- (R)-1-Boc-(3-Hydroxymethyl)piperazine
- Purity
- 95+% ee
- Packaging
- 25g
- Price
- $476
- Updated
- 2021/12/16
AK Scientific
- Product number
- X4711
- Product name
- (R)-3-Hydroxymethyl-piperazine-1-carboxylicacidtert-butylester
- Packaging
- 10g
- Price
- $517
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- CCH0037750
- Product name
- (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $526
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB151258
- Product name
- (R)-4-N-Boc-2-hydroxymethyl-piperazine
- Packaging
- 2g
- Price
- $619
- Updated
- 2021/12/16
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(R)-1-BOC-3-(Hydroxymethyl)piperazine Chemical Properties,Usage,Production
Uses
(R)-1-Boc-3-hydroxymethylpiperazine is a used as a building block for the preparation of PI3K inhibitors for rheumatoid arthritis treatment,benzoxaborole derivatives as antimalarial agents and anti-tuberculosis agents.
Synthesis
1,4-bis-Boc-2-hydroxymethylpiperazine (13.9 kg) and 95% ethanol (30 kg) were added to the reactor, followed by the addition of an aqueous solution (water 21 kg) of configured sodium hydroxide (3.5 kg). The reaction mixture was then heated to reflux. Once the reaction was completed, ethanol was concentrated under reduced pressure. Subsequently, 30 kg of dichloromethane was added and the mixture was separated into liquid and aqueous phases. The aqueous phase was extracted three times with 3 × 20 kg of dichloromethane, and the organic phases were combined. The resulting solution was washed once with 40 kg of a 15% aqueous sodium chloride solution and dried with anhydrous sodium sulfate. Further purification was carried out to obtain (R)-1-BOC-3-(Hydroxymethyl)piperazine.
(R)-1-BOC-3-(Hydroxymethyl)piperazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (R)-1-BOC-3-(Hydroxymethyl)piperazine manufacturers
Zibo Hangyu Biotechnology Development Co., Ltd
- Product
- (R)-1-BOC-3-(Hydroxymethyl)piperazine 278788-66-2
- Price
- US $98.00-990.00/g
- Min. Order
- 5g
- Purity
- 98%
- Supply Ability
- 50
- Release date
- 2024-07-12
Career Henan Chemical Co
- Product
- (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 278788-66-2
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-08-05
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