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(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine

Product Name
(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine
CAS No.
147081-44-5
Chemical Name
(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine
Synonyms
tert-butyl (S)-3-aminopyrrolidine-1-carboxylate;(S)-(-)-1-BOC-3-AMINOPYRROLIDINE;(S)-TERT-BUTYL 3-AMINOPYRROLIDINE-1-CARBOXYLATE;(S)-1-BOC-3-AMINOPYRROLIDINE;tert-Butyl (3S)-3-aminopyrrolidine-1-carboxylate;(3S)-3-aminopyrroL;(S)-3-Amino-n-boc-pyrr;(S)-3-Amino-1-Boc-pyrroli...;(s)-n-boc-3-aminopyrrolidine;(S)-3-AMINO-N-BOC-PYRROLIDINE
CBNumber
CB7853113
Molecular Formula
C9H18N2O2
Formula Weight
186.25
MOL File
147081-44-5.mol
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(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine Property

alpha 
-2 º (c=1, chloroform)
Boiling point:
216-217 °C(lit.)
Density 
1.067 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.4720(lit.)
Flash point:
196 °F
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
form 
Liquid
pka
9.55±0.20(Predicted)
color 
Clear colorless to yellow
optical activity
[α]20/D 2°, c = 1 in chloroform
Sensitive 
Air Sensitive
BRN 
8312125
InChI
InChI=1S/C9H18N2O2/c1-9(2,3)13-8(12)11-5-4-7(10)6-11/h7H,4-6,10H2,1-3H3/t7-/m0/s1
InChIKey
CMIBWIAICVBURI-ZETCQYMHSA-N
SMILES
N1(C(OC(C)(C)C)=O)CC[C@H](N)C1
CAS DataBase Reference
147081-44-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,C,Xi
Risk Statements 
22-41
Safety Statements 
26
RIDADR 
UN 2810 6.1/PG 3
WGK Germany 
2
HazardClass 
8
PackingGroup 
III
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
634794
Product name
(S)-(?)-1-Boc-3-aminopyrrolidine
Purity
95%
Packaging
1g
Price
$54.6
Updated
2025/07/31
Sigma-Aldrich
Product number
634794
Product name
(S)-(?)-1-Boc-3-aminopyrrolidine
Purity
95%
Packaging
5g
Price
$161
Updated
2025/07/31
TCI Chemical
Product number
B2921
Product name
(3S)-(-)-1-(tert-Butoxycarbonyl)-3-aminopyrrolidine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$63
Updated
2025/07/31
TCI Chemical
Product number
B2921
Product name
(3S)-(-)-1-(tert-Butoxycarbonyl)-3-aminopyrrolidine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$187
Updated
2025/07/31
TRC
Product number
B810580
Product name
(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine
Packaging
50mg
Price
$60
Updated
2021/12/16
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(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liqui

Uses

(S)-(-)-1-Boc-3-aminopyrrolidine may be used to prepare:

  • Descarboxamide analog of 4-N-(Nω-nitro-L-argininyl)-trans-4-amino-L-proline amide.
  • Histamine 3 (H3) receptor antagonists containing pyrrolidin-3-yl-N-methylbenzamide moiety.

Synthesis

125552-56-9

147081-44-5

To a solution of compound 178 (2.0 g, 9.42 mmol, 1.0 eq.) in methanol (40 mL) was added palladium carbon (1.0 g, 0.94 mmol, 0.1 eq.). The reaction mixture was subjected to hydrogenation at atmospheric pressure and room temperature for 6 hours. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure. The target compound (S)-1-Boc-3-aminopyrrolidine was obtained as a yellow oil (1.7 g, 97% yield).

References

[1] Patent: US2009/221565, 2009, A1. Location in patent: Page/Page column 51
[2] Patent: WO2016/34134, 2016, A1. Location in patent: Paragraph 00470
[3] Patent: CN105399698, 2016, A. Location in patent: Paragraph 1340-1342
[4] Patent: WO2005/811, 2005, A1. Location in patent: Page/Page column 61
[5] Patent: WO2005/20975, 2005, A2. Location in patent: Page/Page column 221

(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Di-tert-butyl dicarbonate Sodium hydroxide Isopropyl alcohol 1-Butanol (3S)-(+)-3-Aminopyrrolidine dihydrochloride

Preparation Products

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(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine Suppliers

Americas 1 Belgium 1 Canada 1 China 287 Europe 4 France 3 Germany 7 India 5 Japan 3 South Korea 1 Switzerland 1 The Netherlands 1 United Kingdom 15 United States 58 Global 388
INTATRADE GmbH
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View Lastest Price from (S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
(S)-1-Boc-3-Aminopyrrolidine 147081-44-5
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-11-27
Hebei Chuanghai Biotechnology Co., Ltd
Product
(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine 147081-44-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-31
Hebei Yanxi Chemical Co., Ltd.
Product
(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine 147081-44-5
Price
US $20.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-11-02

147081-44-5, (S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidineRelated Search:

(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine (2R,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate (2S,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate hydrochloride N-Boc-cis-4-Fmoc-Amino-L-proline (3R,4R)-tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate (1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE (2S,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate (3r)-(+)-1-(tert-butoxycarbonyl)-3-aminopyrrolidine,(R)-(+)-N-tert-Butoxycarbonyl-3-aminopyrrolidine 1-TERT-BUTOXYCARBONYL-3-AMINOPYRROLIDINE (S)-3-Aminopyrrolidine 3-Aminopyrrolidine trans-3-Amino-4-(4-methylphenyl)pyrrolidine, N-BOC protected (S)-(+)-N-BOC-3-N-FMOC-AMINOPYRROLIDINE& 3-AMINO-4-PHENYLPYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (S)-1-BOC-3-N-(PYRIDIN-4-YLMETHYL)-AMINO-PYRROLIDINE (S)-(+)-N-BOC-4-AMINO-L-PROLINE, 97 (2S,4S)-BOC-4-(BOC-AMINO)-PROLINE (2S,4S)-1-BOC-2-HYDROXYMETHYL-4-AMINO PYRROLIDINE-HCL

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  • 1-PYRROLIDINECARBOXYLIC ACID, 3-AMINO-, 1,1-DIMETHYLETHYL ESTER, (3S)-
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  • 147081-44-5
  • Heterocyclic Building Blocks
  • Pyrrolidines
  • Asymmetric Synthesis
  • Chiral Building Blocks
  • Chiral Building Blocks
  • Heterocyclic Building Blocks
  • Pyrrolidines
  • Benzenes
  • 3-Aminopyrrolidines
  • Chiral 3-Aminopyrrolidines
  • pharmacetical
  • chiral
  • Pyrrole&Pyrrolidine&Pyrroline