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Meglumine

Product Name
Meglumine
CAS No.
6284-40-8
Chemical Name
Meglumine
Synonyms
-D-gL;ucamine;Meglumin;C7H18NO5;MeguMine;MEGLUMINE;Meglumine CRS;Methylglucamin;N-Methyl-D-Glu;MEGLUMINE, USP
CBNumber
CB6411710
Molecular Formula
C7H17NO5
Formula Weight
195.21
MOL File
6284-40-8.mol
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Meglumine Property

Melting point:
129-131.5 °C (lit.)
alpha 
-16.5 º (c=10, H2O, on dry sub)
Boiling point:
331.88°C (rough estimate)
Density 
1.2669 (rough estimate)
refractive index 
-16.5 ° (C=2, H2O)
RTECS 
LZ4295770
storage temp. 
2-8°C
solubility 
H2O: 0.1 g/mL, clear, colorless
pka
pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate)
form 
Crystalline Powder
color 
White to almost white
PH
11 (10g/l, H2O, 20℃)
optical activity
[α]20/D 16.5±0.5°, c = 2% in H2O
Water Solubility 
100 g/100 mL (25 ºC)
Sensitive 
Air Sensitive & Hygroscopic
Merck 
14,6078
BRN 
385906
InChIKey
MBBZMMPHUWSWHV-VZFHVOOUSA-N
NIST Chemistry Reference
N-methylglucamine(6284-40-8)
EPA Substance Registry System
Meglumine (6284-40-8)
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Safety

Risk Statements 
36/37/38
Safety Statements 
24/25
WGK Germany 
3
3-10-23
Autoignition Temperature
~662 °F
TSCA 
Yes
HS Code 
29221980
Toxicity
LD50 orally in Rabbit: > 5000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
66930
Product name
N-Methyl-D-glucamine
Purity
ReagentPlus , ≥99.0% (T)
Packaging
100g
Price
$37.8
Updated
2020/08/18
Sigma-Aldrich
Product number
Y0001209
Product name
Meglumine
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
Sigma-Aldrich
Product number
8.18318
Product name
D(-)-N-Methylglucamine
Purity
for resolution of racemates for synthesis
Packaging
250 g
Price
$53.37
Updated
2021/03/22
Sigma-Aldrich
Product number
1379140
Product name
Meglumine
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$366
Updated
2021/03/22
TCI Chemical
Product number
M0227
Product name
N-Methyl-D-glucamine
Purity
>99.0%(T)
Packaging
25g
Price
$17
Updated
2021/03/22
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Meglumine Chemical Properties,Usage,Production

Chemical Properties

white to almost white crystalline powder

Chemical Properties

Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor.

Uses

antiinflammatory

Uses

excipient in cosmetics and X-ray contrast media

Definition

ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis.

Production Methods

Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation.

brand name

Renovue (Bracco).

Pharmaceutical Applications

Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media.

Safety

Meglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient.
LD50 (mouse, IP): 1.68 g/kg

storage

Meglumine does not polymerize or dehydrate unless heated above 150°C for prolonged periods.
The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended.

Purification Methods

Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.]

Incompatibilities

Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizide.

Regulatory Status

Included in the FDA Inactive Ingredients Database (injections; oral tablets). Included in parenteral medicines licensed in the UK.

Meglumine Preparation Products And Raw materials

Raw materials

Preparation Products

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Meglumine Suppliers

Shanghai changwei industrial development co., LTD
Tel
13262956501
Email
cli@sunwayshanghai.com
Country
China
ProdList
298
Advantage
58
Zhengzhou Yuanli Biological Technology Co., Ltd.
Tel
0371-67897870-
Fax
0371-63507390
Email
2130541246@qq.com
Country
China
ProdList
102
Advantage
58
Wuhan Huajiu Pharmaceutical Technology Co.,Ltd.
Tel
027-59225746-
Fax
027-59225746
Email
730880265@qq.com
Country
China
ProdList
3470
Advantage
58
Hubei widely chemical technology Co., Ltd.
Tel
027-59402396-
Fax
027-83989310
Email
13419635609@163.com
Country
China
ProdList
1841
Advantage
55
Hubei XinghengKang Chemical Technology Co., Ltd.
Tel
027-88878869-
Fax
027-88878869
Email
xhkhu2014@163.com
Country
China
ProdList
212
Advantage
58
Hubei Lingyan Biotechnology Co., Ltd
Email
2331003879@qq.com
Country
China
ProdList
56
Advantage
58
Zhongxiang Yaowei Biological Technology Co., Ltd.
Tel
153-37241005- ;
Email
w13260682861@163.com;516219607@qq.com
Country
China
ProdList
2487
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3579
Advantage
66
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View Lastest Price from Meglumine manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Meglumine 6284-40-8
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-09-26
Wuhan Mulei New Material Technology Co. Ltd
Product
Meglumine 6284-40-8
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99.9%
Supply Ability
100000kg per month
Release date
2021-04-03
Wuhan Aoliqisi New Material Technology Co., Ltd.
Product
Meglumine 6284-40-8
Price
US $1.00/g
Min. Order
1000g
Purity
99%
Supply Ability
20ton/month
Release date
2021-07-13

6284-40-8, MeglumineRelated Search:


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