ChemicalBook > CAS DataBase List > Meglumine

Meglumine

Product Name
Meglumine
CAS No.
6284-40-8
Chemical Name
Meglumine
Synonyms
N-METHYL-D-GLUCAMINE;N-METHYLGLUCAMINE;Meglumin;Methylglucamine;1-deoxy-1-(methylamino)-d-glucito;MeguMine;Meglumine CRS;Methylglucamin;D(-)-N-METHYLGLUCAMINE;1-DEOXY-1-(METHYLAMINO)-D-GLUCITOL
CBNumber
CB6411710
Molecular Formula
C7H17NO5
Formula Weight
195.21
MOL File
6284-40-8.mol
More
Less

Meglumine Property

Melting point:
129-131.5 °C (lit.)
alpha 
-16.5 º (c=10, H2O, on dry sub)
Boiling point:
331.88°C (rough estimate)
Density 
1.2669 (rough estimate)
refractive index 
-16.5 ° (C=2, H2O)
RTECS 
LZ4295770
storage temp. 
2-8°C
solubility 
H2O: 0.1 g/mL, clear, colorless
form 
Crystalline Powder
pka
pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate)
color 
White to almost white
PH
11 (10g/l, H2O, 20℃)
optical activity
[α]20/D 16.5±0.5°, c = 2% in H2O
Water Solubility 
100 g/100 mL (25 ºC)
Sensitive 
Air Sensitive & Hygroscopic
Merck 
14,6078
BRN 
385906
InChIKey
MBBZMMPHUWSWHV-VZFHVOOUSA-N
LogP
-3.370 (est)
NIST Chemistry Reference
N-methylglucamine(6284-40-8)
EPA Substance Registry System
Meglumine (6284-40-8)
More
Less

Safety

Risk Statements 
36/37/38
Safety Statements 
24/25
WGK Germany 
3
F 
3-10-23
Autoignition Temperature
~662 °F
TSCA 
Yes
HS Code 
29221980
Toxicity
LD50 orally in Rabbit: > 5000 mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.18318
Product name
D(-)-N-Methylglucamine
Purity
for resolution of racemates for synthesis
Packaging
250g
Price
$72.3
Updated
2024/03/01
Sigma-Aldrich
Product number
66930
Product name
N-Methyl-D-glucamine
Purity
ReagentPlus , ≥99.0% (T)
Packaging
100g
Price
$67.8
Updated
2024/03/01
Sigma-Aldrich
Product number
1379140
Product name
Meglumine
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
1.06143
Product name
Meglumine
Purity
low in endotoxins, EMPROVE? API, Ph. Eur., ChP, JP, USP
Packaging
1KG
Price
$244
Updated
2022/05/15
Sigma-Aldrich
Product number
1.06187
Product name
Meglumine
Purity
EMPROVE? ESSENTIAL, Ph. Eur., ChP, JP, USP
Packaging
1KG
Price
$244
Updated
2022/05/15
More
Less

Meglumine Chemical Properties,Usage,Production

Chemical Properties

white to almost white crystalline powder

Chemical Properties

Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor.

Uses

antiinflammatory

Uses

excipient in cosmetics and X-ray contrast media

Uses

N-Methyl-D-glucamine is used in conjunction with iodinated organic compounds in contrast media viz. diatrizoate meglumine and iodipamide meglumine. It is useful in ion-exchange resins to chelate boron ions selectively. It is also used as an excipient in pharmaceuticals, in cosmetics and X-ray contrast media. It is also employed in the synthesis of surface active agents, pharmaceuticals and dyes.

Production Methods

Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation.

Definition

ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis.

brand name

Renovue (Bracco).

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Meglumine is a glucose-derived secondary amine which is widely used as an excipient in pharmaceutical formulations.

Pharmaceutical Applications

Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media.

Safety

Meglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient.
LD50 (mouse, IP): 1.68 g/kg

storage

Meglumine does not polymerize or dehydrate unless heated above 150°C for prolonged periods.
The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended.

Purification Methods

Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.]

Incompatibilities

Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizide.

Regulatory Status

Included in the FDA Inactive Ingredients Database (injections; oral tablets). Included in parenteral medicines licensed in the UK.

Meglumine Preparation Products And Raw materials

Raw materials

weak 1-Glucose-methylamine schiffbase ACETALDEHYDE AMMONIA

Preparation Products

More
Less

Meglumine Suppliers

Americas 1 Belgium 3 Brazil 1 Canada 1 China 535 Czech Republic 1 Europe 4 Germany 11 India 38 Japan 6 Mexico 1 Poland 1 Russia 1 South Korea 2 Spain 1 Switzerland 4 The Netherlands 1 United Kingdom 21 United States 62 Global 695
Wuhan Dingxintong Pharmaceutical Co. , Ltd.
Tel
027-027-52344656 15871722230
Fax
2796190295
Email
15871722230@163.com
Country
China
ProdList
3012
Advantage
58
Zhengzhou Yuanli Biological Technology Co., Ltd.
Tel
0371-67897870 18339906974
Fax
0371-63507390
Email
2130541246@qq.com
Country
China
ProdList
107
Advantage
58
Hubei XinghengKang Chemical Technology Co., Ltd.
Tel
027-88878869 18162384755
Fax
027-88878869
Email
xhkhu2014@163.com
Country
China
ProdList
238
Advantage
58
Hubei Lingyan Biotechnology Co., Ltd
Tel
027-59304846 13297025796
Email
2331003879@qq.com
Country
China
ProdList
60
Advantage
58
Zhongxiang Yaowei Biological Technology Co., Ltd.
Tel
15337241005 13260682861
Email
w13260682861@qq.com
Country
China
ProdList
2437
Advantage
58
Hubei widely chemical technology Co., Ltd.
Tel
027-59402396 13419635609
Fax
027-83989310
Email
13419635609@163.com
Country
China
ProdList
1991
Advantage
55
Hubei jian chu biological technology co., LTD
Tel
027-027-65528353 13554206703
Email
3279834739@qq.com
Country
China
ProdList
1075
Advantage
58
Wuhan Huajiu Pharmaceutical Technology Co.,Ltd.
Tel
027-59225746 18062681621
Fax
027-59225746
Email
730880265@qq.com
Country
China
ProdList
4796
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2341
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18501085097
Fax
010-89508210
Email
sales3.gd@hwrkchemical.com
Country
China
ProdList
7583
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12426
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
Advantage
60
shanghai science Bio-Pharmceutical.co,ltd.
Tel
021-021-57872719 13761402923
Fax
02157872719
Email
245662540@qq.com
Country
China
ProdList
308
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9551
Advantage
66
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9816
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8849
Advantage
52
Suzhou Tianma Specialty Chemicals Co.,Ltd.
Tel
+86-512-66319723
Fax
+86-512-68090175
Country
China
ProdList
110
Advantage
67
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7815
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14443
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Aemon Chemical
Tel
0086-755-86198205
Email
acinfo@aemonchem.com
Country
China
ProdList
1937
Advantage
57
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11714
Advantage
57
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9664
Advantage
60
Wuhan Fortuna Chemical Co., Ltd
Tel
027-027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2893
Advantage
58
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4647
Advantage
58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4941
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9725
Advantage
55
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9900
Advantage
58
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
4979
Advantage
50
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9872
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17779
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6139
Advantage
55
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9901
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19918
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18216
Advantage
56
Simagchem Corp.
Tel
86 592 2680277
Fax
0086 592 2680237
Email
sale@simagchem.com
Country
China
ProdList
430
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25015
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9552
Advantage
55
Shanghai Ruji Biology Technology Co., Ltd.
Tel
+86-21-65211385-8001 36031160
Fax
+86-21-65211385-8004
Email
sales@shruji.com
Country
China
ProdList
3224
Advantage
55
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4576
Advantage
55
Nanjing Dulai Biotechnology Co., Ltd.
Tel
025-84699383-8003 18013301590
Fax
025-84699383-8003
Email
njduly@126.com
Country
China
ProdList
973
Advantage
55
Wuxi Zhangkun Biochemical Technology Co., Ltd.
Tel
+86 0510-85629785
Fax
+86 0510-85625359
Country
China
ProdList
2331
Advantage
58
More
Less

View Lastest Price from Meglumine manufacturers

Hebei Saisier Technology Co., LTD
Product
Meglumine 6284-40-8
Price
US $6.00/KG
Min. Order
1KG
Purity
More than 99%
Supply Ability
2000KG/MONTH
Release date
2024-04-22
Shanghai Aosiris new Material Technology Co., LTD
Product
Meglumine 6284-40-8
Price
US $3.00-1.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10 tons
Release date
2024-04-03
Henan Fengda Chemical Co., Ltd
Product
Meglumine 6284-40-8
Price
US $8.00-1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-28

6284-40-8, MeglumineRelated Search:

meglumine-gadolinium-edt FLUNIXIN MEGLUMINE SALT,FLUNIXINE MEGLUMINE SALT,FLUNIXIN MEGLUMINE N-METHYL GLUCAMINE ANTIMONIATE / MEGLUMINE ANTIMONIATE Diatrizoate meglumine (USP),MEGLUMINE DIATRIZOATE,DIATRIZOATE MEGLUMINE,diatrizoic acid meglumine salt Flunixin meglumine Liometacen (meglumine salt),Liometacen [as meglumine salt] D-GLUCAMINE Glucosamine gadolinium DOTA meglumine iodipamide meglumine salt,meglumine iodipamide MEGLUMINE - REFERENCE SPECTRUM Iothalamate meglumine meglumine ioxithalamate,ioxitalamic acid meglumine salt meglumine iodamide,iodamide meglumine salt meglumine indomethacinate MEGLUMINE DIATRIAZOATE iodoxamic acid meglumine salt FLUNIXIN MEGLUMINE IMP. C (EP): ETHYL 2-CHLOROPYRIDINE-3-CARBOXYLATE

  • 1-deoxy-1-(methylamino)-d-glucito
  • 1-Deoxy-1-(methylamino)hexitol
  • Glucitol, 1-deoxy-1-(methylamino)-, D-
  • Meglumin
  • Methylglucamin
  • Methylglucamine
  • D-GLUCITOL, 1-DEOXY-1-(METHYLAMINO)-
  • D(-)-N-METHYLGLUCAMINE
  • MEGLUMINE
  • 1-DEOXY-1-(METHYLAMINO)GLUCITOL
  • 1-DEOXY-1-METHYLAMINOSORBITOL
  • 1-DEOXY-1-(METHYLAMINO)-D-GLUCITOL
  • N-METHYL-D(-)-GLUCAMINE
  • N-METHYL-D-GLUCAMINE
  • N-METHYLGLUCAMINE
  • Methylglucamine,99%
  • <i>N</i>-Methyl-<i>D</i>-glucamine
  • N-Methyl-D-Glucamine(Or) Meglumine
  • N-Methyl-D-glucamine Vetec(TM) reagent grade, 99%
  • Fosaprepitant Impurity H
  • C7H18NO5
  • D(-)-N-Methylglucamine for resolution of racemates for synthesis
  • methyl-[(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]ammonium
  • ucamine
  • N-Methyl-D-Glu
  • METHYL GLUCAMINE MEGLUMINE
  • MEGLUMINE, USP
  • N-Methylglucamine (Meglumine)
  • N-Methyl-D-Glucamine>99%
  • MeglumineAntimoniateBase
  • N-METHYL-D-GLUCANINE
  • MEGLUMINE(N-METHYLGLUCAMINE)
  • N-METHYLCYCLOHEXALAMINE
  • N-METHYL-D-GLUCAMINE USP
  • 1-(Methylamino)-1-deoxy-D-glucitol
  • 1-Methylamino-1-deoxy-D-glucitol
  • D-1-Deoxy-1-(methylamino)glucitol
  • MegluMine (AS)
  • Meglumine, 1-Deoxy-1-(methylamino)-D-glucitol, (2R,3R,4R,5S)-6-Methylaminohexane-1,2,3,4,5-pentaol, 1-Deoxy-1-methylaminosorbitol
  • N-MethylglucaMin (MegluMine)
  • Meglumine (500 mg) (AS)
  • N-Methyl-D-glucaMine, 99% 100GR
  • N-Methyl-D-glucaMine, 99% 2.5KG
  • N-Methyl-D-glucaMine, 99% 500GR
  • MegluMine,USP,BP,EP
  • MeguMine
  • N-Methyl-D-glucaMine 99.0-100.5% (titration)
  • N-Methyl-D-glucaMine ReagentPlus(R), >=99.0% (T)
  • N-Methyl-D-glucaMine , 99.0%(T)
  • N-MethylglucaMine USP
  • D(-)-N-METHYLGLUCAMINE FOR RESOLUTION OF
  • (2R,3R,4R,5S)-6-(MethylaMino)hexane-1,2,3,4,5-pentaol
  • The most popular N-methylglucamine
  • Meglumine CRS
  • N-Methyl-D-glucamine, 99%, reagent grade
  • N-Methyl-D-glucamine&gt
  • -D-gL
  • Meglumine, USP, EP, BP