gadolinium DOTA meglumine
- Product Name
- gadolinium DOTA meglumine
- CAS No.
- 92943-93-6
- Chemical Name
- gadolinium DOTA meglumine
- Synonyms
- gadoteric acid meglumine;Dotarem;MEGLUMINE GADOTERATE;Gadoteric acid meglumine salt;P 449;Magnescope;Gd-DOTA meglumine;Gaboterate Meglumine;Gsdolnium DOTA meglumino;gadolinium DOTA meglumine
- CBNumber
- CB31359182
- Molecular Formula
- C23H42GdN5O13
- Formula Weight
- 753.86
- MOL File
- 92943-93-6.mol
gadolinium DOTA meglumine Property
- form
- Solid
- color
- White to off-white
- Major Application
- pharmaceutical (small molecules)
- InChIKey
- RYHQMKVRYNEBNJ-TXRPULLXNA-K
- SMILES
- [C@@H](O)([C@@H](O)CNC)[C@H](O)[C@H](O)CO.O=C1CN23CCN45CCN67CCN8(CC2)CC(=O)[O-][Gd+3]3486([O-]C(=O)C5)([O-]C(=O)C7)[O-]1.[H+] |&1:0,2,7,9,r|
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
- Hazardous Substances Data
- 92943-93-6(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
gadolinium DOTA meglumine Chemical Properties,Usage,Production
Uses
Gadolinium Dota Meglumine is used in the preparation of Macrocyclic Gadolinium-?Based Contrast Agents.
Definition
ChEBI: An organoammonium salt obtained by reaction of gadoteric acid with one equivalent of 1-deoxy-1-(methylamino)-D-glucitol (meglumine). It is used in magnetic resonance imaging (MRI) in brain (intracranial), spine and associated tissues of pa ients ages 2 years and older, to detect and visualise areas with disruption of the blood brain barrier and/or abnormal vascularity of the central nervous system.
Synthesis
Add 11.8kg of chloroacetic acid and 12l of purified water to 100L reactor, stir to dissolve, add 15l of water dissolved with 5kg of sodium hydroxide under ice bath, add 3.2kg of rotary cyclotonin suspended in 6l of water to the reaction, warm up to 80~85??, add 6l of water dissolved with 5.2kg of sodium hydroxide dropwise, control the reaction system pH 10~11, react overnight, cool down to room temperature, then add 10.4l of concentrated hydrochloric acid dropwise, adjust the pH to 2~2.5, filter and collect the filter cake and dry to obtain 7.5kg of crude gadoterate glucosamine. After dropwise addition of 10.4l concentrated hydrochloric acid, adjust the pH to 2 ~ 2.5, stirring precipitation, filtration to collect the cake, drying gadoteric acid glucosamine crude 7.5 kg. In a 50L reactor, add gadoteric acid glucosamine crude 7.5 kg, 18 kg of purified water, heating and stirring to dissolve, cooling and precipitation, filtration, washing, drying gadoteric acid glucosamine 6.21 kg, yield 82.7%, which contains the salt amount of 2%. The content of salt was 2%.
gadolinium DOTA meglumine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from gadolinium DOTA meglumine manufacturers
- Product
- Magnescope 92943-93-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-09-29
- Product
- gadolinium DOTA meglumine 92943-93-6
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-07-29
- Product
- gadolinium DOTA meglumine 92943-93-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27