DOTA

Product Name: DOTA
CAS No.: 60239-18-1
Chemical Name: DOTA
Synonyms: TETRAXETAN;1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID;2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid;DOTA;TETRAAZA;98% DOTA;DOTADOTA;NSC 681107;DOTA, ≥97%;DOTA(M-140)
CBNumber: CB9398467
Molecular Formula: C16H28N4O8
Formula Weight: 404.42
MOL File: 60239-18-1.mol

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DOTA Property

Melting point:: 267 °C
Boiling point:: 701.6±60.0 °C(Predicted)
Density: 1.321
storage temp.: Sealed in dry,Room Temperature
solubility: Water (Slightly, Heated), Methanol (Slightly)
pka: 2.16±0.10(Predicted)
form: Powder
color: white
BRN: 1186987
Stability:: Hygroscopic
InChI: InChI=1S/C16H28N4O8/c21-13(22)9-17-1-2-18(10-14(23)24)5-6-20(12-16(27)28)8-7-19(4-3-17)11-15(25)26/h1-12H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28)
InChIKey: WDLRUFUQRNWCPK-UHFFFAOYSA-N
SMILES: N1(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 3-10-34
HS Code: 29339900
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 86734
Product name: 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid
Purity: ≥97.0% (CHN)
Packaging: 50mg
Price: $151
Updated: 2026/03/19

Sigma-Aldrich

Product number: 86734
Product name: 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid
Purity: ≥97.0% (CHN)
Packaging: 250mg
Price: $163
Updated: 2026/03/19

Sigma-Aldrich

Product number: 1652158
Product name: Tetraxetan
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 50mg
Price: $438
Updated: 2026/03/19

TCI Chemical

Product number: T1875
Product name: 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid
Purity: >97.0%(T)
Packaging: 200mg
Price: $141
Updated: 2026/03/19

TCI Chemical

Product number: T1875
Product name: 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid
Purity: >97.0%(T)
Packaging: 1g
Price: $497
Updated: 2026/03/19

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DOTA Chemical Properties,Usage,Production

Chemical Properties

Colourless crystals

Uses

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is a macrocyclic complexing agent.

It has been used for radiolabeling of carbon nanotube bioconjugates by chelating ⁶⁴Cu radioisotope.
DOTA can be activated with N-hydroxysulfosuccinimidyl for conjugation with monoclonal antibodies in clinical radioimmunotherapy.
It can form complexes with gadolinium for application as MRI contrast agents.
Metal complexes of DOTA-peptide conjugates can be used as therapeutic radiopharmaceuticals.

Uses

Bifunctional DOTA aconjugates to peptides and has become an established strategy for constructing target-specific metal containing agents including targeted MRI contrast agents and diagnostic and ther apeutic radiopharmaceuticals.

Definition

ChEBI: An azamacrocyle in which four nitrogen atoms at positions 1, 4, 7 and 10 of a twelve-membered ring are each substituted with a carboxymethyl group.

Synthesis

79-11-8

294-90-6

60239-18-1

To a three-necked flask, 1,4,7,10-tetraazacyclododecane (100 g, 0.58 mol) and 10 ml of deionized water were added and mixed with stirring. The pH of the reaction system was adjusted to 8.5 by slow dropwise addition of 30% potassium hydroxide solution.Subsequently, chloroacetic acid (263 g, 2.78 mol) was added and the pH was adjusted again to 8.5 using 30% potassium hydroxide solution.The reaction mixture was heated to 80 °C and kept for 24 h, during which time the pH was continually monitored and adjusted to maintain a pH value between 8.5 and 9. After completion of the reaction, it was cooled to room temperature and the pH was adjusted to 2 by adding concentrated hydrochloric acid, at which time a white precipitate was produced. The precipitate was collected by filtration and the filter cake was recrystallized from a mixed water-ethanol solution. The resulting crystals were washed with ethanol and ether in turn, and 183 g of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) crystals were obtained after drying with a yield of 78%.

References

[1] Journal of Labelled Compounds and Radiopharmaceuticals, 2003, vol. 46, # 3, p. 197 - 209
[2] Dalton Transactions, 2016, vol. 45, # 23, p. 9553 - 9564
[3] Patent: WO2014/114664, 2014, A1. Location in patent: Page/Page column 28-29
[4] Patent: WO2015/117911, 2015, A1. Location in patent: Paragraph 0081; 0082; 0083; 0084
[5] Patent: CN104447598, 2017, B. Location in patent: Paragraph 0096; 0098; 0099

DOTA Preparation Products And Raw materials

Raw materials

Preparation Products

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DOTA Suppliers

Canada 1 China 298 France 1 Germany 4 India 17 Japan 1 South Korea 1 Switzerland 1 Ukraine 1 United Kingdom 2 United States 15 Global 342

shanghaikeyiyuan Technology Co., Ltd

Tel: 15316056835
Email: 545311776@qq.com
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Chem-Stone Co.,Ltd.

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Viwit Pharmaceutical Co., Ltd.

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HAINAN POLY PHARMCEUTICAL CO. LTD

Tel: +86-0571-89385087 +86-13616530509
Email: gaoying@hnpoly.com
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Shanghai GL Peptide Ltd.

Tel: +86-21-61263340; 17609490614 13764994101
Fax: 021-61263399
Email: fisherwang@glschina.com
Country: China
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Henan Mengtai Pharmaceutical Technology Co., Ltd

Tel: 17634413542
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Country: China
ProdList: 9999
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Shandong Longchen Pharmaceutical Co., Ltd.

Tel: 15964061209 15964061209
Email: yangyy@longzenpharma.com
Country: China
ProdList: 357
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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
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Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
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TCI (Shanghai) Development Co., Ltd.

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View Lastest Price from DOTA manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 1,4,7,10-Tetraazacyclododecane- 1,4,7,10-tetraacetic-acid 60239-18-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2024-08-01

Hebei Chuanghai Biotechnology Co., Ltd

Product: DOTA 60239-18-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-29

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: DOTA 60239-18-1
Price: US $35.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-05-29

60239-18-1, DOTARelated Search:

1,4,7,10-Tetrakis(ethoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane DOTA Gadoteric acid 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 2-[(4-isothiocyanatophenyl)methyl]- TETRYL 12-Crown-4 Eu-DOTA,Europium DOTA TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD GADOMELITOL DOTA-[TYR3]-OCTREOTATE,DOTA-[TYR3]-OCTREOTIDE ACID,DOTA-FCYWKTCT (DISULFIDE BRIDGE: 2-7),DOTA-D-PHE-CYS-TYR-D-TRP-LYS-THR-CYS-THR-OH (DISULFIDE BRIDGE: 2-7) DOTA-D-PHE-CYS-TYR-D-TRP-LYS-THR-CYS-THR-OL (DISULFIDE BRIDGE: 2-7) gadolinium DOTA meglumine DOTA-BIM-23014:DOTA-Lanreotide,DOTA-Lanreotide DOTA-(Tyr3)-Octreotate Iron DOTA Sodium Salt DOTA-glycyl-glycyl-glycyl-(4-nitrophenyl)alanine amide DOTA-NOC, DOTA-[Nal3]-octreotide,DOTA-NOC yttrium-90-DOTA-peptide-chimeric L6

1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraaceticacid,min.98%DOTA

1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID, FREE ACID

1,4,7,10-TETRAAZACYCLODODECANE-N,N',N'',N'''-TETRAACETIC ACID

DOTA

TETRAAZA-12-CROWN-4-1,4,7,10-TETRAACETIC ACID

NSC 681107

Gadobutrol Impurity 6（DOTA）

DOTA60239-18-1

TETRAAZA

DOTA(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid)

Gadobutrol Impurity 12

2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetic acid

2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid

TETRAAZA-12-CROWN-4 TETRAACETIC ACID AMMONIUM SALT (SEE 2923)

Tetraxetan/radical

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrakisacetic acid

2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetryl)tetraacetic acid

2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetryl)tetrakisacetic acid

1,4,7,10-TETRAAZACYCLODODECANE-N,N'',N , N''-TETRAACETIC ACID , (DOTA)

1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID DOTA

DOTA(M-140)

Tetraxetan/DOTA/1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid >=97.0% (CHN)

DOTA Tetraxetan 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid

2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid

4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid

2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane -1,4,7,10-tetrayl)tetraacetic acid(DOTA)

1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane

Tetraxetanum (DOTA)

1,4,7,10-Tetraazacyclododecan-N,N',N,N'-tetraacetic acid

TetraxetanuM

Atosiban impurity 9

Gadobutrol Impurity 35

DOTA, ≥97%

98% DOTA

TETRAXETAN(DOTA)

Tritracine tetraacetic acid

Gadolinium Butanol Impurity 6

Gadolinium Butanol Impurity 11

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic

(3aR,4aS)-4a-(3-fluorophenyl)-1,3,3a,4a-tetrahydrocyclopropa[1,2-c]furan-1-one

DOTA (TETRAXETAN)

(1,4,7,10-tetra-carboxymethyl -1,4,7,10-teraaza-cyclododec -1-yl)-acetic acid(DOTA)

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid hydrate

1,4,7,10-tetraazacyclododecane-N,N’,N’’,N’’’-tetraaceticacid(DOTA)

DOTADOTA

Lunhuan Tengning Tetraacetic Acid

1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA)

Gadolinium alcohol impurity 6

DOTA (1,4,7,10-TETRAAZACYCLODODECANE-1,4,7）

Gd-DTA intermediate

monogadolinium(III) mono(2,2'-(4,10-bis((2S,3R)-1,3,4-trihydroxybutan-2-yl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate)

TETRAXETAN

1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID

60239-18-1

60239-28-1

C16H28N4O8xH2O

C16H28N4O8