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DOTA

Product Name
DOTA
CAS No.
60239-18-1
Chemical Name
DOTA
Synonyms
TETRAXETAN;1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID;2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid;DOTA;TETRAAZA;98% DOTA;NSC 681107;DOTA, ≥97%;DOTA(M-140);TetraxetanuM
CBNumber
CB9398467
Molecular Formula
C16H28N4O8
Formula Weight
404.42
MOL File
60239-18-1.mol
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DOTA Property

Melting point:
267 °C
Boiling point:
701.6±60.0 °C(Predicted)
Density 
1.321
storage temp. 
Sealed in dry,Room Temperature
solubility 
Water (Slightly, Heated), Methanol (Slightly)
pka
2.16±0.10(Predicted)
form 
Powder
color 
white
BRN 
1186987
Stability:
Hygroscopic
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
F 
3-10-34
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
86734
Product name
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid
Purity
≥97.0% (CHN)
Packaging
50mg
Price
$138
Updated
2024/03/01
Sigma-Aldrich
Product number
86734
Product name
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid
Purity
≥97.0% (CHN)
Packaging
250mg
Price
$148
Updated
2024/03/01
TCI Chemical
Product number
T1875
Product name
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid
Purity
>97.0%(T)
Packaging
200mg
Price
$157
Updated
2024/03/01
TCI Chemical
Product number
T1875
Product name
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid
Purity
>97.0%(T)
Packaging
1g
Price
$552
Updated
2024/03/01
Strem Chemicals
Product number
07-1942
Product name
1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid, min. 98% DOTA
Packaging
250mg
Price
$120
Updated
2024/03/01
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DOTA Chemical Properties,Usage,Production

Chemical Properties

Colourless crystals

Uses

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is a macrocyclic complexing agent.

  • It has been used for radiolabeling of carbon nanotube bioconjugates by chelating 64Cu radioisotope.
  • DOTA can be activated with N-hydroxysulfosuccinimidyl for conjugation with monoclonal antibodies in clinical radioimmunotherapy.
  • It can form complexes with gadolinium for application as MRI contrast agents.
  • Metal complexes of DOTA-peptide conjugates can be used as therapeutic radiopharmaceuticals.

Uses

Bifunctional DOTA aconjugates to peptides and has become an established strategy for constructing target-specific metal containing agents including targeted MRI contrast agents and diagnostic and ther apeutic radiopharmaceuticals.

Definition

ChEBI: An azamacrocyle in which four nitrogen atoms at positions 1, 4, 7 and 10 of a twelve-membered ring are each substituted with a carboxymethyl group.

DOTA Preparation Products And Raw materials

Raw materials

Preparation Products

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DOTA Suppliers

Canada 1 China 266 France 1 Germany 4 India 17 Japan 1 South Korea 1 Switzerland 1 Ukraine 1 United Kingdom 2 United States 16 Global 311
ShenZhen InnoSyn Biotech Co.,Ltd
Tel
0755-28351685 18503098468
Fax
+86-755-28466854
Email
innosyn@163.com
Country
China
ProdList
600
Advantage
55
Chem-Stone Co.,Ltd.
Tel
020-020-82185713
Fax
020-82185696
Email
sales@chem-stone.com
Country
China
ProdList
741
Advantage
56
Viwit Pharmaceutical Co., Ltd.
Tel
0632-2980981 15063270987
Fax
0632-2989678
Email
service.china3@viwit.com
Country
China
ProdList
117
Advantage
55
HAINAN POLY PHARMCEUTICAL CO. LTD
Tel
+86-0571-89385087 +86-13616530509
Email
gaoying@hnpoly.com
Country
China
ProdList
50
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94838
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9551
Advantage
66
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View Lastest Price from DOTA manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
DOTA 60239-18-1
Price
US $0.00/g
Min. Order
100g
Purity
>95.00%
Supply Ability
100g
Release date
2024-04-01
Hebei Yanxi Chemical Co., Ltd.
Product
DOTA 60239-18-1
Price
US $10.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
30 tons
Release date
2023-09-07
WUHAN FORTUNA CHEMICAL CO., LTD
Product
1,4,7,10-Tetraazacyclododecane- 1,4,7,10-tetraacetic-acid 60239-18-1
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-08

60239-18-1, DOTARelated Search:

1,4,7,10-Tetrakis(ethoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane DOTA Gadoteric acid 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 2-[(4-isothiocyanatophenyl)methyl]- TETRYL 12-Crown-4 Eu-DOTA,Europium DOTA TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD GADOMELITOL DOTA-[TYR3]-OCTREOTATE,DOTA-[TYR3]-OCTREOTIDE ACID,DOTA-FCYWKTCT (DISULFIDE BRIDGE: 2-7),DOTA-D-PHE-CYS-TYR-D-TRP-LYS-THR-CYS-THR-OH (DISULFIDE BRIDGE: 2-7) DOTA-D-PHE-CYS-TYR-D-TRP-LYS-THR-CYS-THR-OL (DISULFIDE BRIDGE: 2-7) gadolinium DOTA meglumine DOTA-BIM-23014:DOTA-Lanreotide,DOTA-Lanreotide DOTA-(Tyr3)-Octreotate Iron DOTA Sodium Salt DOTA-glycyl-glycyl-glycyl-(4-nitrophenyl)alanine amide DOTA-NOC, DOTA-[Nal3]-octreotide,DOTA-NOC yttrium-90-DOTA-peptide-chimeric L6

  • TETRAXETAN
  • 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraaceticacid,min.98%DOTA
  • 1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID
  • 1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID, FREE ACID
  • 1,4,7,10-TETRAAZACYCLODODECANE-N,N',N'',N'''-TETRAACETIC ACID
  • DOTA
  • TETRAAZA-12-CROWN-4-1,4,7,10-TETRAACETIC ACID
  • NSC 681107
  • Gadobutrol Impurity 6（DOTA）
  • DOTA60239-18-1
  • TETRAAZA
  • DOTA(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid)
  • Gadobutrol Impurity 12
  • 2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetic acid
  • 2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
  • TETRAAZA-12-CROWN-4 TETRAACETIC ACID AMMONIUM SALT (SEE 2923)
  • Tetraxetan/radical
  • 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrakisacetic acid
  • 2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetryl)tetraacetic acid
  • 2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetryl)tetrakisacetic acid
  • 1,4,7,10-TETRAAZACYCLODODECANE-N,N'',N , N''-TETRAACETIC ACID , (DOTA)
  • 1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID DOTA
  • DOTA(M-140)
  • Tetraxetan/DOTA/1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid
  • 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid >=97.0% (CHN)
  • DOTA Tetraxetan 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid
  • 2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid
  • 4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid
  • 2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane -1,4,7,10-tetrayl)tetraacetic acid(DOTA)
  • 1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane
  • Tetraxetanum (DOTA)
  • 1,4,7,10-Tetraazacyclododecan-N,N',N,N'-tetraacetic acid
  • TetraxetanuM
  • Atosiban impurity 9
  • Gadobutrol Impurity 35
  • DOTA, ≥97%
  • 98% DOTA
  • TETRAXETAN(DOTA)
  • Tritracine tetraacetic acid
  • Gadolinium Butanol Impurity 6
  • Gadolinium Butanol Impurity 11
  • 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic
  • (3aR,4aS)-4a-(3-fluorophenyl)-1,3,3a,4a-tetrahydrocyclopropa[1,2-c]furan-1-one
  • DOTA (TETRAXETAN)
  • Gadolinium alcohol impurity 6
  • (1,4,7,10-tetra-carboxymethyl -1,4,7,10-teraaza-cyclododec -1-yl)-acetic acid(DOTA)
  • 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid hydrate
  • 2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid
  • 60239-18-1
  • 60239-28-1
  • C16H28N4O8xH2O
  • C16H28N4O8
  • Synthetic Reagents
  • Crown Ethers
  • Chelation/Complexation Compounds
  • Achiral Nitrogen
  • Cy-N
  • Azacrown Ethers