12-Crown-4

Product Name: 12-Crown-4
CAS No.: 294-93-9
Chemical Name: 12-Crown-4
Synonyms: Crown;1,4,7,10-TETRAOXACYCLODODECANE;12-CROWN 4-ETHER;Eoct;12C4;12 C 4;12-C-4;12-CROWN-4;12-Crown-4,97%;LITHIUM IONOPHORE V
CBNumber: CB8752442
Molecular Formula: C8H16O4
Formula Weight: 176.21
MOL File: 294-93-9.mol

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12-Crown-4 Property

Melting point:: 16 °C (lit.)
Boiling point:: 61-70 °C/0.5 mmHg (lit.)
Density: 1.089 g/mL at 25 °C (lit.)
refractive index: n20/D 1.463(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Liquid After Melting
Specific Gravity: 1.115 (20℃)
color: Clear colorless to slightly yellow
Water Solubility: MISCIBLE
Sensitive: Air Sensitive
BRN: 1363064
CAS DataBase Reference: 294-93-9(CAS DataBase Reference)
NIST Chemistry Reference: 12-Crown-4(294-93-9)
EPA Substance Registry System: 1,4,7,10-Tetraoxacyclododecane (294-93-9)

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Safety

Hazard Codes: T+,Xn,Xi
Risk Statements: 26-36/37/38-20/21/22
Safety Statements: 28-36/37-45-36-26
RIDADR: UN 2810
WGK Germany: 3
RTECS: XF0550000
F: 3-9-23
TSCA: Yes
HazardClass: 6.1
PackingGroup: III
HS Code: 29329995
Toxicity: LD50 oral in rat: 2830mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H330Fatal if inhaled

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 194905
Product name: 12-Crown-4
Purity: 98%
Packaging: 1g
Price: $62.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: 194905
Product name: 12-Crown-4
Purity: 98%
Packaging: 5g
Price: $148
Updated: 2024/03/01

TCI Chemical

Product number: C0858
Product name: 12-Crown 4-Ether
Purity: >95.0%(GC)
Packaging: 1mL
Price: $54
Updated: 2024/03/01

TCI Chemical

Product number: C0858
Product name: 12-Crown 4-Ether
Purity: >95.0%(GC)
Packaging: 5mL
Price: $177
Updated: 2024/03/01

Alfa Aesar

Product number: A11972
Product name: 12-Crown-4, 98%
Packaging: 1g
Price: $76.65
Updated: 2024/03/01

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12-Crown-4 Chemical Properties,Usage,Production

Chemical Properties

clear colorless to slightly yellow liquid after

Uses

It serves as an aprotic "solvent" for alkali metals, the sodium solution is a strong reducing agent.

Uses

12-Crown-4 can be used as:

A promoter in the synthesis of poly(diethylsiloxane) (PDES) from monomer hexaethylcyclotrisiloxane using NaOH as a catalyst via anionic ring-opening polymerization.
As an additive in the preparation of triarylmethane derivatives by palladium-catalyzed cross coupling reaction of aryl bromides with diarylmethane derivatives.
A phase transfer catalyst in organic synthesis.

Definition

ChEBI: A crown ether that is cyclododecane in which the carbon atoms at positions 1, 4, 7 and 10 have been replaced by oxygen atoms.

Synthesis Reference(s)

Tetrahedron Letters, 15, p. 4029, 1974 DOI: 10.1016/S0040-4039(01)92075-1

General Description

12-Crown-4 is a crown ether generally used as a ligand in coordination chemistry. It is also known as lithium ionophore because of its strong chelating property specific to lithium cation.

Purification Methods

The distilled crude product has to be recrystallised from pentane at -20o to remove acyclic material. It is then dried over P2O5. It complexes Li. [Anet et al. Acta Chem Scand 27 3395 1973, Beilstein 19/11 V 334.]

12-Crown-4 Preparation Products And Raw materials

Raw materials

Preparation Products

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12-Crown-4 Suppliers

Americas 1 Belgium 1 Canada 1 China 137 Europe 4 Germany 4 India 10 Japan 3 Slovakia 1 South Korea 1 Switzerland 3 Ukraine 1 United Kingdom 9 United States 25 Global 201

J & K SCIENTIFIC LTD.

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View Lastest Price from 12-Crown-4 manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 12-Crown-4 294-93-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 12-Crown-4 294-93-9
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-17

Career Henan Chemical Co

Product: 12-Crown-4 294-93-9
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-17

294-93-9, 12-Crown-4Related Search:

1,7-DIAZA-12-CROWN-4,4,10-DIAZA-12-CROWN 4-ETHER BIS[(12-CROWN-4)METHYL] DODECYLMETHYLMALONATE 2-(HYDROXYMETHYL)-12-CROWN 4-ETHER Tetraaza 12-crown-4 1-AZA-12-CROWN 4-ETHER,1-AZA-12-CROWN-4,AZA-12-CROWN-4,aza-12-crown-499.5+% BENZO-12-CROWN-4,BENZO-12-CROWN 4-ETHER,Benzo-12-crown-4, 99+%,BENZO-12-CROWN-4 98+% 1-aza-12-crown-5 TETRAAZA-12-CROWN-4-1,4,7,10-TETRAACETIC ACID,TETRAAZA-12-CROWN-4 TETRAACETIC ACID AMMONIUM SALT (SEE 2923) TETRAAZA-12-CROWN-4 TETRAHYDROCHLORIDE CYCLODODECANE N-METHYLAZA-12-CROWN-4 4-TERT-BUTYL-CALIX[4]ARENE-CROWN-4-COMPLEX 1-BENZYL-1-AZA-12-CROWN-4,N-BENZYLAZA-12-CROWN-4 TETRAAZA-12-CROWN-4 TETRAHYDROGENSULFATE 12-Crown-4 Cyclohexyl-12-crown-4 Tetraaza 12-crown-4-tetraacetic acid derivative BIS[(12-CROWN-4)METHYL] 2,2-DIDODECYLMALONATE

LITHIUM IONOPHORE V

CROWN ETHER/12-CROWN-4

Crown

Eoct

Ethylene oxide cyclic tetramer

1,4,7,10-TETRAOXYCYCLODODECANE

1,4,7,10-TETRAOXACYCLODODECANE

12-CROWN 4-ETHER

12-CROWN-4

1,4,7,10-Tetraoxacyclododecane, 12-Crown-4

12-Crown-4,97%

CROWN ETHER/12-CROWN-4 FOR SYNTHESIS

12-Crown-4 Cyclic tetraMer of ethylene oxide which is specific for the lithiuM cation., 98%

12-Crown-4(1,4,7,10-Tetraoxacyclododecane)

12-Crown 4-Ether &gt

294-93-9 12-Crown-4

12 C 4

12C4

12-C-4

294-93-9

294-93-6

Chelation/Complexation Compounds

Macrocycles for Host-Guest Chemistry

Crown Ethers

Synthetic Reagents

Crown Ethers

Functional Materials

Macrocycles for Host-Guest Chemistry