Cyclen
- Product Name
- Cyclen
- CAS No.
- 294-90-6
- Chemical Name
- Cyclen
- Synonyms
- 1,4,7,10-TETRAAZACYCLODODECANE;1,4,7,10-Tetrazacyclododecane;Gm-D;CYCLEN;NSC 629374;Cyclen,97%;Cyclen(M-100);Cyclen, >=99%;Kryptofix 11 aza;Cyclen≥ 99% (GC)
- CBNumber
- CB5158782
- Molecular Formula
- C8H20N4
- Formula Weight
- 172.27
- MOL File
- 294-90-6.mol
Cyclen Property
- Melting point:
- 110-113 °C (lit.)
- Boiling point:
- 292.61°C (rough estimate)
- Density
- 1.0415 (rough estimate)
- vapor pressure
- 0.004Pa at 20℃
- refractive index
- 1.5872 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 10.53±0.20(Predicted)
- form
- Crystalline Powder
- color
- Almost white to slightly yellow
- Water Solubility
- almost transparency
- BRN
- 606114
- Stability:
- hygroscopic
- InChIKey
- QBPPRVHXOZRESW-UHFFFAOYSA-N
- LogP
- -0.63 at 20℃
- CAS DataBase Reference
- 294-90-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/38-36/37/38
- Safety Statements
- 26-36
- RIDADR
- 1759
- WGK Germany
- 3
- RTECS
- XA5253000
- F
- 3-9-34
- Hazard Note
- Irritant
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H311Toxic in contact with skin
H314Causes severe skin burns and eye damage
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 339652
- Product name
- Cyclen
- Purity
- 97%
- Packaging
- 250mg
- Price
- $224
- Updated
- 2024/03/01
- Product number
- T1874
- Product name
- 1,4,7,10-Tetraazacyclododecane
- Purity
- >97.0%(GC)(T)
- Packaging
- 1g
- Price
- $28
- Updated
- 2024/03/01
- Product number
- T1874
- Product name
- 1,4,7,10-Tetraazacyclododecane
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $83
- Updated
- 2024/03/01
- Product number
- 07-1941
- Product name
- 1,4,7,10-Tetraazacyclododecane, min. 98% CYCLEN
- Packaging
- 1g
- Price
- $69
- Updated
- 2024/03/01
- Product number
- 07-1941
- Product name
- 1,4,7,10-Tetraazacyclododecane, min. 98% CYCLEN
- Packaging
- 5g
- Price
- $209
- Updated
- 2024/03/01
Cyclen Chemical Properties,Usage,Production
Chemical Properties
almost white to slightly yellow crystalline powder, soluble in methanol, ethanol, dmso and other organic solvents, derived from stephania cepharantha.
Uses
Cyclen is an azamocrocycle, which can be used in the development of fluorescent nanosensors for the detection of metal ions.
Application
Cyclen (1,4,7,10-tetraazacyclododecane) is a macrocyclic aza analogue of the crown ether 12-crown-4. Cyclen compounds are capable of selectively binding cations and are used as a ligand with chemicals used in MRI contrast (as well ass other imaging) agents.
Definition
ChEBI: 1,4,7,10-tetraazacyclododecane is an azacycloalkane that is cyclododecane in which the carbon atoms at positions 1, 4, 7 and 10 are replaced by nitrogen atoms. It is a saturated organic heteromonocyclic parent, a crown amine and an azacycloalkane.
Synthesis Reference(s)
Journal of the American Chemical Society, 96, p. 2268, 1974 DOI: 10.1021/ja00814a056
General Description
Cyclen is a microcyclic tetramine that can be used as a ligand that forms a co-ordination linkage with the surface metal cations. It can be used as a synthetic precursor. It can be prepared by S-alkylation of dithiooxamide with an excess amount of bromoethane.
Flammability and Explosibility
Not classified
Synthesis
Some syntheses exploit the Thorpe-Ingold effect to facilitate ring-formation. Illustrative is the reaction of the deprotonated tosylamides with ditosylates:
TsN(CH2CH2NTsNa)2 + TsN(CH2CH2OTs)2 → (TsNCH2CH2)4
The resulting macrocycle can be deprotected with strong acid. Base gives the tetramine.
High dilution conditions result in a low reaction rate penalty and this disadvantage is removed in an alternative procedure starting from triethylenetetraamine and dithiooxamide to a bisamidine – also a bis(imidazoline) – followed by reduction and ring expansion with DIBAL.
In one study cyclen is covalently bonded through a propylene molecular spacer to adenine and chelated with zinc diperchlorate. This complex is able to selectively bind uracil and uridine in a 1:2 ratio both through the adenine part and cyclen part of the molecule as evidenced by mass spectrometry.
wiki/Cyclen
Cyclen Preparation Products And Raw materials
Raw materials
Preparation Products
Cyclen Suppliers
- Tel
- 21-21-20222982 13124863828
- sales@linkchem.cn
- Country
- China
- ProdList
- 3010
- Advantage
- 58
- Tel
- 020-82185713,82185709 13418171485
- Fax
- 020-82185696
- sales@chem-stone.com
- Country
- China
- ProdList
- 742
- Advantage
- 56
- Tel
- 15662658101
- Fax
- 0531-88989539
- sales@finerchem.com
- Country
- China
- ProdList
- 315
- Advantage
- 58
- Tel
- 14793566
- info@cenpharm.com
- Country
- China
- ProdList
- 698
- Advantage
- 58
- Tel
- 13331045123
- Fax
- 86-10-80339217
- 1963319514@qq.com
- Country
- China
- ProdList
- 14223
- Advantage
- 58
- Tel
- 571-8526-3177 13962438025
- beixi.dong@heryipharma.com
- Country
- China
- ProdList
- 165
- Advantage
- 58
- Tel
- 13376089542
- gusx@neutanpharma.com
- Country
- China
- ProdList
- 77
- Advantage
- 58
- Tel
- 18860950986
- tangmanman@lebangpharma.com
- Country
- China
- ProdList
- 564
- Advantage
- 58
- Tel
- 15150528611
- Fax
- 151-5052-8611
- 779881375@qq.com
- Country
- China
- ProdList
- 71
- Advantage
- 58
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
- Advantage
- 55
View Lastest Price from Cyclen manufacturers
- Product
- Cyclen 294-90-6
- Price
- US $120.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-29
- Product
- Cyclen 294-90-6
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000kg
- Release date
- 2024-05-14
- Product
- Cyclen 294-90-6
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100mt/year
- Release date
- 2021-06-08