HC TOXIN

Product Name: HC TOXIN
CAS No.: 83209-65-8
Chemical Name: HC TOXIN
Synonyms: Toxin I;HC TOXIN;HC toxin I;Cyclo(aoe-Pro-Ala-ala);HC TOXIN FROM HELMINTHOSPORIUM CARBONUM;HC Toxin, histone deacetylase (HDAC) inhibitor;HC toxin from Helminthosporium carbonum;Cyclo[D-Pro-L-Ala-D-Ala-2-(6-oxo-6-oxiranylhexyl)-L-Gly-];CYCLO-(D-PRO-L-ALA-D-ALA-L-2-AMINO-8-OXO-9,10-EPOXYDECANOIC ACID);Cyclo[L-Ala-D-Ala-[(2S)-2-amino*-8-oxo-8-oxiranyloctanoyl]-D-Pro-]
CBNumber: CB2460604
Molecular Formula: C21H32N4O6
Formula Weight: 436.51
MOL File: 83209-65-8.mol

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HC TOXIN Property

Boiling point:: 819.2±65.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 10 mg/ml; Methanol: 10 mg/ml
form: lyophilized powder
pka: 13.33±0.70(Predicted)
color: Off-white to light yellow

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H7270
Product name: HC toxin from Helminthosporium carbonum
Purity: lyophilized powder
Packaging: 5mg
Price: $767
Updated: 2022/05/15

Cayman Chemical

Product number: 10576
Product name: HC Toxin
Purity: ≥95%
Packaging: 500μg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 10576
Product name: HC Toxin
Purity: ≥95%
Packaging: 1mg
Price: $165
Updated: 2024/03/01

Cayman Chemical

Product number: 10576
Product name: HC Toxin
Purity: ≥95%
Packaging: 5mg
Price: $721
Updated: 2024/03/01

TRC

Product number: H115005
Product name: HCToxin
Packaging: 5mg
Price: $1540
Updated: 2021/12/16

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HC TOXIN Chemical Properties,Usage,Production

Description

HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC₅₀ = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize.

Uses

HC Toxin is an HDAC inhibitor. Cyclic tetrapeptide[1] fungal toxin selectively toxic to plants with susceptible host genotype (2)

Definition

ChEBI: A homodetic cyclic tetrapeptide made up from L-alanyl, D-alanyl, L-prolyl and 2-amino-8-oxo-9,10-epoxydecanoyl residues.

Biochem/physiol Actions

Cyclic tetrapeptide fungal toxin selectively toxic to plants with susceptible host genotype.

References

[1] G BROSCH. Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum.[J]. Plant Cell, 1995, 7 11: 1941-1950. DOI: 10.1105/tpc.7.11.1941
[2] S J DARKIN-RATTRAY. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1996, 93 23: 13143-13147. DOI: 10.1073/pnas.93.23.13143
[3] H. KAMITANI. Expression of 15-lipoxygenase-1 is regulated by histone acetylation in human colorectal carcinoma.[J]. Carcinogenesis, 2001, 22 1 1: 187-191. DOI: 10.1093/carcin/22.1.187
[4] HUA CAO George S. Histone deacetylase inhibitor FK228 is a potent inducer of human fetal hemoglobin[J]. American Journal of Hematology, 2006, 81 12: 981-983. DOI: 10.1002/ajh.20676
[5] WALTON J. HC-toxin.[J]. Phytochemistry, 2020, 67 14 1: 1406-1413. DOI: 10.32388/5s7act

HC TOXIN Preparation Products And Raw materials

Raw materials

Preparation Products

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HC TOXIN Suppliers

China 57 Switzerland 2 United States 9 USA 1 Global 69

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
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Country: China
ProdList: 25003
Advantage: 65

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
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Sigma-Aldrich

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Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
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Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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BOC Sciences

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Shaanxi Dideu Medichem Co. Ltd

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Shanghai Hewu Biotechnology Co., LTD

Tel: 021-57886085 17317861055
Email: shhebio@126.com
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83209-65-8, HC TOXINRelated Search:

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HC TOXIN FROM HELMINTHOSPORIUM CARBONUM

Cyclo[D-Pro-L-Ala-D-Ala-2-(6-oxo-6-oxiranylhexyl)-L-Gly-]

Cyclo[L-Ala-D-Ala-[(2S)-2-amino*-8-oxo-8-oxiranyloctanoyl]-D-Pro-]

HC toxin I

Toxin I

Cyclic(L-alanyl-D-alanyl-eta-oxo-L-alpha-aminooxiraneoctanoyl-D-prolyl)

Cyclo(2-amino-8-oxo-9,10-epoxydecanoic acid-prolyl-alanyl-alanine)

Cyclo(aoe-Pro-Ala-ala)

Cyclo(L-alanyl-D-alanyl-(alphas,2S)-alpha-amino-eta-oxooxiraneoctanoyl-D-prolyl)

Cyclo(L-alanyl-D-alanyl-8-oxiranyl-8-oxo-L-2-aminooctanoyl-D-prolyl), (S)-

(3S,6R,9S,12R)-6,9-dimethyl-3-[6-[(2S)-oxiran-2-yl]-6-oxohexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone

CYCLO-(D-PRO-L-ALA-D-ALA-L-2-AMINO-8-OXO-9,10-EPOXYDECANOIC ACID)

HC TOXIN

HC Toxin, histone deacetylase (HDAC) inhibitor

HC toxin from <i>Helminthosporium carbonum</i>

83209-65-8

C21H32N4O6

Cell Signaling and Neuroscience

Mold

Toxins and Venoms