CAY10603

Product Name: CAY10603
CAS No.: 1045792-66-2
Chemical Name: CAY10603
Synonyms: Isox;187257;BML-281;CAY10603;HDAC6 Inhibitor;CAY10603 ，S7596;CAY10603 CAY10603;HDAC6 inhibitor ISOX;CAY10603, 10 mM in DMSO;CAY10603; CAY-10603; CAY 10603.
CBNumber: CB42590439
Molecular Formula: C22H30N4O6
Formula Weight: 446.5
MOL File: 1045792-66-2.mol

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CAY10603 Property

Density: 1.231±0.06 g/cm3(Predicted)
storage temp.: +2C to +8C
solubility: ≥22.35 mg/mL in DMSO; insoluble in EtOH; ≥24.85 mg/mL in H2O
form: Beige to light brown solid
pka: 9.47±0.20(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 382175-M
Product name: Histone Deacetylase Inhibitor VIII
Purity: The Histone Deacetylase Inhibitor VIII, also referenced under CAS 1045792-66-2, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Struc
Packaging: 1 unit
Price: $195
Updated: 2025/07/31

Cayman Chemical

Product number: 13146
Product name: CAY10603
Purity: ≥95%
Packaging: 1mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 13146
Product name: CAY10603
Purity: ≥95%
Packaging: 5mg
Price: $176
Updated: 2024/03/01

Cayman Chemical

Product number: 13146
Product name: CAY10603
Purity: ≥95%
Packaging: 10mg
Price: $324
Updated: 2024/03/01

Cayman Chemical

Product number: 13146
Product name: CAY10603
Purity: ≥95%
Packaging: 25mg
Price: $578
Updated: 2024/03/01

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CAY10603 Chemical Properties,Usage,Production

Description

Histone deacetylase 6 (HDAC6) is a class II HDAC that represses transcription by removing acetyl groups from histones. In addition, HDAC6 deacetylases tubulin, which is important in regulating microtubule stability and function. CAY10603 is a potent and selective inhibitor of HDAC6 (IC₅₀ = 0.002 nM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively). Also, CAY10603 prevents the growth of several pancreatic cancer cell lines (IC₅₀ = 0.1-1 μM). The HDAC6 inhibitor is more active in inhibiting cell growth than the broad spectrum HDAC inhibitor suberoylanilide hydroxamic acid (SAHA).

Uses

HDAC6 Inhibitor is an inhibitor of HDAC6.

Definition

ChEBI: N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl ester is a carbamate ester.

General Description

A cell-permeable, active site Zn²⁺-targeting phenylisoxazolo-hydroxamate that acts a potent and highly selective HDAC6 inhibitor (IC₅₀ = 0.002, 0.42, 90.7, 252, 271 and 6851 nM against HDAC-6, -3, -10, -2, -1 and -8, respectively). Shown to be more potent than SAHA in inhibiting the proliferation of a panel of pancreatic cancer cell lines (IC₅₀<1.0 μM).

IC 50

HDAC6: 0.002 nM (IC₅₀); HDAC3: 0.42 nM (IC₅₀); HDAC10: 90.7 nM (IC₅₀); HDAC2: 252 nM (IC₅₀); HDAC1: 271 nM (IC₅₀); HDAC8: 6851 nM (IC₅₀)

References

[1] ALAN P. KOZIKOWSKI*. Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6[J]. Journal of Medicinal Chemistry, 2008, 51 15: 4370-4373. DOI: 10.1021/jm8002894

CAY10603 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10603 Suppliers

China 88 India 1 The Netherlands 1 United States 16 Global 106

Shanghai Boyle Chemical Co., Ltd.

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1045792-66-2, CAY10603Related Search:

CarbaMic acid, N-(4-broMo-2-nitrophenyl)-, 1,1-diMethylethyl ester tert-butyl (4-chloro-3-fluoro-2-iodophenyl)carbamate tert-butyl (4-(phenylsulfonyl)benzyl)carbamate Sodium Butyrate Suberohydroxamic acid 1H-Benz[de]isoquinoline-2(3H)-butanamide SCRIPTAID SPLITOMICIN Sodium 4-phenylbutyrate BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE APICIDIN OXAMFLATIN HC TOXIN M344 Parthenolide ACY-1215 Imatinib Nexturastat A

CAY10603

Isox

tert-butyl 4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenylcarbamate

HDAC6 Inhibitor

N-[4-[3-[[[7-(Hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]carbamic acid 1,1-dimethylethyl ester

Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem

CAY10603; CAY-10603; CAY 10603.

187257

HDAC6 inhibitor ISOX

tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate

BML-281

Carbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester

BML 281,inhibit,Histone deacetylases,BML281,CAY-10603,Inhibitor,CAY10603,CAY 10603,HDAC

CAY10603 CAY10603

CAY10603, 10 mM in DMSO

Histone Deacetylase Inhibitor VIII

CAY10603 ，S7596

1045792-66-2

Inhibitors