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CAY10603

Product Name
CAY10603
CAS No.
1045792-66-2
Chemical Name
CAY10603
Synonyms
Isox;187257;BML-281;CAY10603;HDAC6 Inhibitor;CAY10603 CAY10603;HDAC6 inhibitor ISOX;CAY10603; CAY-10603; CAY 10603.;Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem;tert-butyl 4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenylcarbamate
CBNumber
CB42590439
Molecular Formula
C22H30N4O6
Formula Weight
446.5
MOL File
1045792-66-2.mol
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CAY10603 Property

Density 
1.231±0.06 g/cm3(Predicted)
storage temp. 
+2C to +8C
solubility 
≥22.35 mg/mL in DMSO; insoluble in EtOH; ≥24.85 mg/mL in H2O
form 
Beige to light brown solid
pka
9.47±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13146
Product name
CAY10603
Purity
≥95%
Packaging
1mg
Price
$48
Updated
2024/03/01
Cayman Chemical
Product number
13146
Product name
CAY10603
Purity
≥95%
Packaging
5mg
Price
$176
Updated
2024/03/01
Cayman Chemical
Product number
13146
Product name
CAY10603
Purity
≥95%
Packaging
10mg
Price
$324
Updated
2024/03/01
Cayman Chemical
Product number
13146
Product name
CAY10603
Purity
≥95%
Packaging
25mg
Price
$578
Updated
2024/03/01
TRC
Product number
H999763
Product name
HDAC6Inhibitor
Packaging
500μg
Price
$55
Updated
2021/12/16
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CAY10603 Chemical Properties,Usage,Production

Description

Histone deacetylase 6 (HDAC6) is a class II HDAC that represses transcription by removing acetyl groups from histones. In addition, HDAC6 deacetylases tubulin, which is important in regulating microtubule stability and function. CAY10603 is a potent and selective inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively). Also, CAY10603 prevents the growth of several pancreatic cancer cell lines (IC50 = 0.1-1 μM). The HDAC6 inhibitor is more active in inhibiting cell growth than the broad spectrum HDAC inhibitor suberoylanilide hydroxamic acid (SAHA).

Uses

HDAC6 Inhibitor is an inhibitor of HDAC6.

Definition

ChEBI: N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl ester is a carbamate ester.

General Description

A cell-permeable, active site Zn2+-targeting phenylisoxazolo-hydroxamate that acts a potent and highly selective HDAC6 inhibitor (IC50 = 0.002, 0.42, 90.7, 252, 271 and 6851 nM against HDAC-6, -3, -10, -2, -1 and -8, respectively). Shown to be more potent than SAHA in inhibiting the proliferation of a panel of pancreatic cancer cell lines (IC50<1.0 μM).

CAY10603 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10603 Suppliers

China 64 India 1 The Netherlands 1 United States 15 Global 81
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6011
Advantage
61
ChemShuttle, Inc.
Tel
0510-83588313-802 18800520310;
Email
sales@chemshuttle.com
Country
China
ProdList
3062
Advantage
62
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
Shanghai Qinghang Chemical Co. Ltd.
Tel
021-50840321, 18601625411
Fax
021-50840321
Email
thomasleehz@hotmail.com
Country
China
ProdList
216
Advantage
50
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4121
Advantage
55
YouCoChem (Beijing) Chemical Technology Co., Ltd.
Tel
18800159827
Email
youcochem@163.com
Country
China
ProdList
161
Advantage
50

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  • CAY10603
  • Isox
  • tert-butyl 4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenylcarbamate
  • HDAC6 Inhibitor
  • N-[4-[3-[[[7-(Hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]carbamic acid 1,1-dimethylethyl ester
  • Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem
  • CAY10603; CAY-10603; CAY 10603.
  • 187257
  • HDAC6 inhibitor ISOX
  • tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate
  • BML-281
  • Carbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester
  • BML 281,inhibit,Histone deacetylases,BML281,CAY-10603,Inhibitor,CAY10603,CAY 10603,HDAC
  • CAY10603 CAY10603
  • 1045792-66-2
  • Inhibitors