M344
- Product Name
- M344
- CAS No.
- 251456-60-7
- Chemical Name
- M344
- Synonyms
- M344;CS-661;MS 344;MS 344, D237;M344 (D 237);M344 USP/EP/BP;M 344 (enzyme inhibitor);HISTONE DEACETYLASE INHIBITOR III;Histone Deacetylase Inhibitor III(M344);N-HYDROXY-7-(4-DIMETHYLAMINOBENZOYL)AMINOHEPTANAMIDE
- CBNumber
- CB0673778
- Molecular Formula
- C16H25N3O3
- Formula Weight
- 307.39
- MOL File
- 251456-60-7.mol
M344 Property
- Melting point:
- 161℃
- Density
- 1.137±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble10mg/mL, clear
- pka
- 9.48±0.20(Predicted)
- form
- White solid
- color
- white to beige
- Sensitive
- Light Sensitive
- CAS DataBase Reference
- 251456-60-7
Safety
- WGK Germany
- 3
- HS Code
- 2928.00.2500
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M5820
- Product name
- M344
- Purity
- ≥98% (HPLC), powder
- Packaging
- 1mg
- Price
- $229
- Updated
- 2024/03/01
- Product number
- 382149
- Product name
- Histone Deacetylase Inhibitor III
- Packaging
- 1mg
- Price
- $187
- Updated
- 2024/03/01
- Product number
- D4188
- Product name
- 4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
- Purity
- >97.0%(HPLC)
- Packaging
- 20mg
- Price
- $263
- Updated
- 2024/03/01
- Product number
- D4188
- Product name
- 4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
- Purity
- >97.0%(HPLC)
- Packaging
- 100mg
- Price
- $870
- Updated
- 2024/03/01
- Product number
- J64940
- Product name
- Histone Deacetylase Inhibitor III
- Packaging
- 10mg
- Price
- $228
- Updated
- 2021/12/16
M344 Chemical Properties,Usage,Production
Uses
Histone deacetylase inhibitor III. A cell-permeable amide analog of Trichostatin A that potently inhibits HDACs.
Uses
M 344 is an inhibitor of histone deacetylases (HDACs), inhibiting maize HDAC (IC50 = 100 nM) as well as human HDAC1 (IC50 = 46 nM). It shows a three-fold selectivity for inhibition of HDAC6 over HDAC1. M 344 enhances the sensitivity of human squamous carcinoma cells to radiation and promotes cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells (ED50 = 2.3 μM).
Definition
ChEBI: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide is a benzamide resulting from the formal condensation of the carboxy group of 4-(dimethylamino)benzoic acid with the amino group of 7-amino-N-hydroxyheptanamide. It is a potent inhibitor of histone deacetylases and induces cell cycle arrest and apoptosis in several human cancer cell lines. It has a role as an apoptosis inducer, an antineoplastic agent and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is a member of benzamides, a hydroxamic acid, a secondary carboxamide and a tertiary amino compound.
General Description
A cell-permeable amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylases (IC50 = 40 nM for rat liver HDAC and IC50 = 100 nM for maize HD). Induces differentiation and inhibits proliferation (~2 μM) of murine erythroleukemia cells.
Biological Activity
Histone deacetylase inhibitor (IC 50 = 100 nM). Induces terminal cell differentiation and causes an increase in hyperacetylated histone H4. Antiproliferative agent; suppresses the growth of human endometrial and ovarian cancer cells by inducing cell cycle arrest and apoptosis.
Biochem/physiol Actions
Cell permeable: yes
References
[1]. jung m, brosch g , kolle d, et al. amide analogues of trichostatin a as inhibitors of histone deacetylase and inducers of terminal cell differentiation. journal of medicinal chemistry, 1999, 42 (22): 4669-4679.
[2]. yeung a, bhargava rk, ahn, r, et al. hdac inhibitor m344 suppresses mcf-7 breast cancer cell proliferation. biomedicine & pharmacotherapy, 2012, 66 (3): 232-236.
[3]. furchert se, lanvers-kaminsky c , jurgens h , et al. inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood. international journal of cancer, 2007, 120 (8): 1787-1794.
[4]. ying h, zhang yh , zhou x , et al. selective histonedeacetylase inhibitor m344 intervenes in hiv-1 latency through increasing histone acetylation and activation of nf-kappab. plos one, 2012, 7 (11): e48832.
M344 Preparation Products And Raw materials
Raw materials
Preparation Products
M344 Suppliers
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View Lastest Price from M344 manufacturers
- Product
- M344 51456-60-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-25