ChemicalBook > CAS DataBase List > M344

M344

Product Name
M344
CAS No.
251456-60-7
Chemical Name
M344
Synonyms
M344;CS-661;MS 344;MS 344, D237;M344 (D 237);M344 USP/EP/BP;M344, 10 mM in DMSO;M344, HDAC inhibitor;M 344 (enzyme inhibitor);HISTONE DEACETYLASE INHIBITOR III
CBNumber
CB0673778
Molecular Formula
C16H25N3O3
Formula Weight
307.39
MOL File
251456-60-7.mol
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M344 Property

Melting point:
161℃
Density 
1.137±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble10mg/mL, clear
pka
9.48±0.20(Predicted)
form 
White solid
color 
white to beige
Sensitive 
Light Sensitive
CAS DataBase Reference
251456-60-7
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Safety

WGK Germany 
3
HS Code 
2928.00.2500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M5820
Product name
M344
Purity
≥98% (HPLC), powder
Packaging
1mg
Price
$229
Updated
2024/03/01
Sigma-Aldrich
Product number
382149
Product name
Histone Deacetylase Inhibitor III
Packaging
1mg
Price
$187
Updated
2024/03/01
TCI Chemical
Product number
D4188
Product name
4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
Purity
>97.0%(HPLC)
Packaging
20mg
Price
$263
Updated
2024/03/01
TCI Chemical
Product number
D4188
Product name
4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
Purity
>97.0%(HPLC)
Packaging
100mg
Price
$870
Updated
2024/03/01
Alfa Aesar
Product number
J64940
Product name
Histone Deacetylase Inhibitor III
Packaging
10mg
Price
$228
Updated
2021/12/16
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M344 Chemical Properties,Usage,Production

Uses

Histone deacetylase inhibitor III. A cell-permeable amide analog of Trichostatin A that potently inhibits HDACs.

Uses

M 344 is an inhibitor of histone deacetylases (HDACs), inhibiting maize HDAC (IC50 = 100 nM) as well as human HDAC1 (IC50 = 46 nM). It shows a three-fold selectivity for inhibition of HDAC6 over HDAC1. M 344 enhances the sensitivity of human squamous carcinoma cells to radiation and promotes cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells (ED50 = 2.3 μM).

Definition

ChEBI: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide is a benzamide resulting from the formal condensation of the carboxy group of 4-(dimethylamino)benzoic acid with the amino group of 7-amino-N-hydroxyheptanamide. It is a potent inhibitor of histone deacetylases and induces cell cycle arrest and apoptosis in several human cancer cell lines. It has a role as an apoptosis inducer, an antineoplastic agent and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is a member of benzamides, a hydroxamic acid, a secondary carboxamide and a tertiary amino compound.

General Description

A cell-permeable amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylases (IC50 = 40 nM for rat liver HDAC and IC50 = 100 nM for maize HD). Induces differentiation and inhibits proliferation (~2 μM) of murine erythroleukemia cells.

Biological Activity

Histone deacetylase inhibitor (IC 50 = 100 nM). Induces terminal cell differentiation and causes an increase in hyperacetylated histone H4. Antiproliferative agent; suppresses the growth of human endometrial and ovarian cancer cells by inducing cell cycle arrest and apoptosis.

Biochem/physiol Actions

Cell permeable: yes

References

[1]. jung m, brosch g , kolle d, et al. amide analogues of trichostatin a as inhibitors of histone deacetylase and inducers of terminal cell differentiation. journal of medicinal chemistry, 1999, 42 (22): 4669-4679.
[2]. yeung a, bhargava rk, ahn, r, et al. hdac inhibitor m344 suppresses mcf-7 breast cancer cell proliferation. biomedicine & pharmacotherapy, 2012, 66 (3): 232-236.
[3]. furchert se, lanvers-kaminsky c , jurgens h , et al. inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood. international journal of cancer, 2007, 120 (8): 1787-1794.
[4]. ying h, zhang yh , zhou x , et al. selective histonedeacetylase inhibitor m344 intervenes in hiv-1 latency through increasing histone acetylation and activation of nf-kappab. plos one, 2012, 7 (11): e48832.

M344 Preparation Products And Raw materials

Raw materials

Preparation Products

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M344 Suppliers

Americas 1 Canada 1 China 93 Europe 1 India 3 Japan 2 Switzerland 2 United Kingdom 5 United States 29 Global 137
J & K SCIENTIFIC LTD.
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View Lastest Price from M344 manufacturers

Career Henan Chemical Co
Product
M344 51456-60-7
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-25

251456-60-7, M344Related Search:

M.W. 4757.45 C208H344N60O63S2 MF-344 AKOS 344 Cyclicdimethylpolysiloxane AA-344 M344 P25 (329-344) 344(R)-(-)-2-Methoxypropanol RAT CDNA, FISHER 344 LIVER LIBRARY RARECHEM AM UF J344 ANTI-RB (AA 332-344), FITC CALCULATOR SHARP MODEL EL344G CALCULATOR, SHARP MODEL EL344G chromogranin A (344-364) ANTI CHROMOGRANIN A (344-374) (HUMAN) ANTI-RB (AA 332-344) CD45RB,LCA(HIGHMW),180,190,205&220KD,EXONB,CLONE:344(BRA-11G),MABANTI-HUMAN,FITC VOLASIL(TM) 344

  • M344
  • HISTONE DEACETYLASE INHIBITOR III
  • 4-DIMETHYLAMINO-N-(6-HYDROXYCARBAMOYLHEXYL)-BENZAMIDE
  • N-HYDROXY-7-(4-DIMETHYLAMINOBENZOYL)AMINOHEPTANAMIDE
  • HISTONE DEACETYLASE INHIBITOR III;D237;D 237;D-237;M-344;M344
  • CS-661
  • 4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide, MS 344, D237, N-Hydroxy-7-(4-dimethylaminobenzoyl)-aminoheptanamide
  • 4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide
  • MS 344
  • M 344 (enzyme inhibitor)
  • 4-(Diethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
  • MS 344, D237
  • Histone Deacetylase Inhibitor III(M344)
  • M344 (D 237)
  • 4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide&gt
  • Benzamide, 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-
  • M344 USP/EP/BP
  • M344 HDAC inhibitor M-344 Histone Deacetylase Inhibitor III
  • M344, HDAC inhibitor
  • M344, 10 mM in DMSO
  • 251456-60-7
  • 51456-60-7
  • DNA-RNA Transcription Regulators
  • Gene Regulation and Expression
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Amines
  • Aromatics
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Inhibitor
  • Apoptosis Inducers