M344

ChemicalBook > CAS DataBase List > M344

Product Name: M344
CAS No.: 251456-60-7
Chemical Name: M344
Synonyms: M344;CS-661;MS 344;MS 344, D237;M344 (D 237);M344 USP/EP/BP;M 344 (enzyme inhibitor);HISTONE DEACETYLASE INHIBITOR III;Histone Deacetylase Inhibitor III(M344);N-HYDROXY-7-(4-DIMETHYLAMINOBENZOYL)AMINOHEPTANAMIDE
CBNumber: CB0673778
Molecular Formula: C16H25N3O3
Formula Weight: 307.39
MOL File: 251456-60-7.mol

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M344 Property

Melting point:: 161℃
Density: 1.137±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear
pka: 9.48±0.20(Predicted)
form: White solid
color: white to beige
Sensitive: Light Sensitive
CAS DataBase Reference: 251456-60-7

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Safety

WGK Germany: 3
HS Code: 2928.00.2500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M5820
Product name: M344
Purity: ≥98% (HPLC), powder
Packaging: 1mg
Price: $229
Updated: 2024/03/01

Sigma-Aldrich

Product number: 382149
Product name: Histone Deacetylase Inhibitor III
Packaging: 1mg
Price: $187
Updated: 2024/03/01

TCI Chemical

Product number: D4188
Product name: 4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
Purity: >97.0%(HPLC)
Packaging: 20mg
Price: $263
Updated: 2024/03/01

TCI Chemical

Product number: D4188
Product name: 4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
Purity: >97.0%(HPLC)
Packaging: 100mg
Price: $870
Updated: 2024/03/01

Alfa Aesar

Product number: J64940
Product name: Histone Deacetylase Inhibitor III
Packaging: 10mg
Price: $228
Updated: 2021/12/16

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M344 Chemical Properties,Usage,Production

Uses

Histone deacetylase inhibitor III. A cell-permeable amide analog of Trichostatin A that potently inhibits HDACs.

Uses

M 344 is an inhibitor of histone deacetylases (HDACs), inhibiting maize HDAC (IC50 = 100 nM) as well as human HDAC1 (IC50 = 46 nM). It shows a three-fold selectivity for inhibition of HDAC6 over HDAC1. M 344 enhances the sensitivity of human squamous carcinoma cells to radiation and promotes cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells (ED50 = 2.3 μM).

Definition

ChEBI: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide is a benzamide resulting from the formal condensation of the carboxy group of 4-(dimethylamino)benzoic acid with the amino group of 7-amino-N-hydroxyheptanamide. It is a potent inhibitor of histone deacetylases and induces cell cycle arrest and apoptosis in several human cancer cell lines. It has a role as an apoptosis inducer, an antineoplastic agent and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is a member of benzamides, a hydroxamic acid, a secondary carboxamide and a tertiary amino compound.

General Description

A cell-permeable amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylases (IC₅₀ = 40 nM for rat liver HDAC and IC₅₀ = 100 nM for maize HD). Induces differentiation and inhibits proliferation (~2 μM) of murine erythroleukemia cells.

Biological Activity

Histone deacetylase inhibitor (IC 50 = 100 nM). Induces terminal cell differentiation and causes an increase in hyperacetylated histone H4. Antiproliferative agent; suppresses the growth of human endometrial and ovarian cancer cells by inducing cell cycle arrest and apoptosis.

Biochem/physiol Actions

Cell permeable: yes

References

[1]. jung m, brosch g , kolle d, et al. amide analogues of trichostatin a as inhibitors of histone deacetylase and inducers of terminal cell differentiation. journal of medicinal chemistry, 1999, 42 (22): 4669-4679.
[2]. yeung a, bhargava rk, ahn, r, et al. hdac inhibitor m344 suppresses mcf-7 breast cancer cell proliferation. biomedicine & pharmacotherapy, 2012, 66 (3): 232-236.
[3]. furchert se, lanvers-kaminsky c , jurgens h , et al. inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood. international journal of cancer, 2007, 120 (8): 1787-1794.
[4]. ying h, zhang yh , zhou x , et al. selective histonedeacetylase inhibitor m344 intervenes in hiv-1 latency through increasing histone acetylation and activation of nf-kappab. plos one, 2012, 7 (11): e48832.

M344 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from M344 manufacturers

Career Henan Chemical Co

Product: M344 51456-60-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

251456-60-7, M344Related Search:

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M344

HISTONE DEACETYLASE INHIBITOR III

4-DIMETHYLAMINO-N-(6-HYDROXYCARBAMOYLHEXYL)-BENZAMIDE

N-HYDROXY-7-(4-DIMETHYLAMINOBENZOYL)AMINOHEPTANAMIDE

HISTONE DEACETYLASE INHIBITOR III;D237;D 237;D-237;M-344;M344

CS-661

4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide, MS 344, D237, N-Hydroxy-7-(4-dimethylaminobenzoyl)-aminoheptanamide

4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide

MS 344

M 344 (enzyme inhibitor)

4-(Diethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide

MS 344, D237

Histone Deacetylase Inhibitor III(M344)

M344 (D 237)

4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide&gt

Benzamide, 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-

M344 USP/EP/BP

M344 HDAC inhibitor M-344 Histone Deacetylase Inhibitor III

251456-60-7

51456-60-7

DNA-RNA Transcription Regulators

Gene Regulation and Expression

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Amines

Aromatics

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Inhibitor

Apoptosis Inducers