Suberohydroxamic acid
- Product Name
- Suberohydroxamic acid
- CAS No.
- 38937-66-5
- Chemical Name
- Suberohydroxamic acid
- Synonyms
- ODHA;SBHA;[PTYR705]-STAT3;STAT3 (PTYR705);SUBEROHYDROXAMIC ACID;SUBERIC BISHYDROXAMATE;SuberohydroxaMic acid 95%;SuberoylBis-hydroxamicAci;suberic bishydroxamic acid;SUBEROYL BISHYDROXAMIC ACID
- CBNumber
- CB6673028
- Molecular Formula
- C8H16N2O4
- Formula Weight
- 204.22
- MOL File
- 38937-66-5.mol
Suberohydroxamic acid Property
- Melting point:
- 153-155 °C(lit.)
- Density
- 1.219±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- H2O: soluble
- pka
- 9.18±0.20(Predicted)
- form
- lyophilized powder
- color
- White to Light Beige
- Stability:
- Hygroscopic
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 2928009090
N-Bromosuccinimide Price
- Product number
- 559418
- Product name
- SBHA
- Packaging
- 100mg
- Price
- $159
- Updated
- 2024/03/01
- Product number
- 390585
- Product name
- Suberohydroxamic acid
- Purity
- 95%
- Packaging
- 1g
- Price
- $77
- Updated
- 2024/03/01
- Product number
- 10574
- Product name
- Suberohydroxamic Acid
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $28
- Updated
- 2024/03/01
- Product number
- 10574
- Product name
- Suberohydroxamic Acid
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $207
- Updated
- 2024/03/01
- Product number
- 10574
- Product name
- Suberohydroxamic Acid
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $63
- Updated
- 2024/03/01
Suberohydroxamic acid Chemical Properties,Usage,Production
Description
Suberohydroxamic acid (SBHA) is a competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC50 = 0.25 μM) and HDAC3 (IC50 = 0.30 μM). SBHA causes cell differentiation, cell cycle arrest, or apoptosis. HDAC inhibitors, including SBHA, act synergistically to kill cancer cells when used in combination with cytostatic drugs, allowing lower doses of both inhibitors and drugs to be used.
Uses
Inhibits histone deacetylation.
Uses
Histone deacetylase inhibitor. A cell-permeable inhibitor of HDAC1 and HDAC3. Shown to suppresses the growth of proliferating keratinocytes and squamous cell carcinoma cells.
Definition
ChEBI: N,N'-dihydroxyoctanediamide is a hydroxamic acid.
Biological Activity
Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. SBHA inhibits the activity of HDAC1 and HDAC3 with IC50 values of 250 and 300 nM, respectively. SBHA inhibits proliferation, and induces apoptosis in several cancer cell lines. SBHA has been shown to activate Notch signaling in medullary thyroid carcinoma (MTC) cells.
Biochem/physiol Actions
Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. SBHA inhibits the activity of HDAC1 and HDAC3 with IC50 values of 250 and 300 nM, respectively. SBHA inhibits proliferation, and induces apoptosis in several cancer cell lines. SBHA has been shown to activate Notch signaling in medullary thyroid carcinoma (MTC) cells.
References
1. richon vm, emiliani s, verdin e et al. a class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. proc natl acad sci u s a. 1998 mar 17; 95(6):3003-7.2. zhang xd, gillespie sk, borrow jm, hersey p. the histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells. mol cancer ther. 2004 apr; 3(4):425-35.
Suberohydroxamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Suberohydroxamic acid manufacturers
- Product
- Suberohydroxamic acid 38937-66-5
- Price
- US $0.00/KG
- Min. Order
- 25KG
- Purity
- 95%
- Supply Ability
- Inquiry
- Release date
- 2023-03-30
- Product
- N,N'-Dihydroxyoctanediamide 38937-66-5
- Price
- US $0.00/KG
- Min. Order
- 25KG
- Purity
- 95%
- Supply Ability
- Inquiry
- Release date
- 2023-03-30
- Product
- OCTANE-1,8-DIHYDROXAMIC ACID 38937-66-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-09