Octanohydroxamic Acid
- Product Name
- Octanohydroxamic Acid
- CAS No.
- 7377-03-9
- Chemical Name
- Octanohydroxamic Acid
- Synonyms
- CaprylhydroxaMic Acid;OCTANOHYDROXAMIC ACID;hydroximic acid;CAPRYLHYDROXAMIC;taselin;n-hydroxy-octanamid;HOHA;Oct-HA;LGB-CHA;PrzvFreeTM CHA
- CBNumber
- CB9150582
- Molecular Formula
- C8H17NO2
- Formula Weight
- 159.23
- MOL File
- 7377-03-9.mol
Octanohydroxamic Acid Property
- Melting point:
- 78°C
- Density
- 0.970
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 9.56±0.20(Predicted)
- color
- White to Off-White
- InChI
- InChI=1S/C8H17NO2/c1-2-3-4-5-6-7-8(10)9-11/h11H,2-7H2,1H3,(H,9,10)
- InChIKey
- RGUVUPQQFXCJFC-UHFFFAOYSA-N
- SMILES
- C(NO)(=O)CCCCCCC
- EPA Substance Registry System
- Octanamide, N-hydroxy- (7377-03-9)
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- RTECS
- RG9900500
- HS Code
- 2928.00.5000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- C1232
- Product name
- Octanohydroxamic Acid
- Purity
- >99.0%(N)
- Packaging
- 5g
- Price
- $89
- Updated
- 2025/07/31
- Product number
- C1232
- Product name
- Octanohydroxamic Acid
- Purity
- >99.0%(N)
- Packaging
- 25g
- Price
- $265
- Updated
- 2025/07/31
- Product number
- 119208
- Product name
- Octanohydroxamic acid
- Purity
- 95+%
- Packaging
- 100g
- Price
- $128
- Updated
- 2021/12/16
- Product number
- FC28962
- Product name
- Caprylohydroxamic acid
- Packaging
- 100g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- FC28962
- Product name
- Caprylohydroxamic acid
- Packaging
- 500g
- Price
- $400
- Updated
- 2021/12/16
Octanohydroxamic Acid Chemical Properties,Usage,Production
Description
Octanohydroxamic acid (OHA), the more common hydroxamate collector, has both an acid group (single bondNHOH) and basic group (single bond CO). The hydrogen in the acid group can be replaced by a metal ion and a dative bond from the basic group to form a chelate. Improved monazite flotation performance was reported when using OHA compared to the results obtained with sodium oleate. Flotation separation of monazite and calcite using OHA has been described in previous publications. OHA was the most potent urease inhibitor among saturated hydroxamic acid (HAs) with a calculated IC50 of 0.25?±?0.1?mM compared to 8.67?±?1.3 and 0.50?±?0.2?mM for Acetohydroxamic acid and heptanohydroxamic acid, respectively. Further increase in the chain length from 8 to 12 carbons negatively affected the potency of HAs[1].
Uses
Octanohydroxamic Acid is used in preparation of Caprylohydroxamic Acid.
Synthesis
106-32-1
7377-03-9
To a 1000 mL four-necked flask was added hydroxylamine hydrochloride (48.7 g, 0.70 mol, 1.4 eq.), water (50 g), and ethanol (200 g, 2.3 times the volume), and stirred at room temperature until hydroxylamine hydrochloride was completely dissolved. Ethyl octanoate (86.7 g, 0.5 mol, 1.0 eq.) was then added and stirred at room temperature to form a two-phase system. The reaction mixture was cooled to 5-10°C and 40% KOH solution (168 g, 1.2 mol, 2.4 eq.) was added slowly and dropwise. After the dropwise addition, the reaction system was heated to 50~55°C and the reaction was held for 3 hours and monitored by gas chromatography (GC) until the ethyl octanoate material completely disappeared. After the reaction was completed, cooled to 5~10°C, slowly added concentrated hydrochloric acid (90 mL) to adjust the pH to 6.4~6.7, at which time a large amount of white solid precipitated. The solid was collected by filtration and dried at 50°C for 8 hours. The crude product was recrystallized with benzene to give 78.8 g of white flocculent solid in 91.1% yield.
References
[1] Diana Evstafeva. “Inhibition of urease-mediated ammonia production by 2-octynohydroxamic acid in hepatic encephalopathy.” Nature Communications 15 1 (2024): 2226.
Octanohydroxamic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Octanohydroxamic Acid manufacturers
- Product
- Octanohydroxamic Acid 7377-03-9
- Price
- US $1.50/g
- Min. Order
- 1g
- Purity
- 99.0% Min
- Supply Ability
- 10 Tons
- Release date
- 2025-06-25
- Product
- Octanohydroxamic Acid 7377-03-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.001kg
- Purity
- 99%
- Supply Ability
- 200000t
- Release date
- 2025-06-12
- Product
- Caprylhydroxamic acid 7377-03-9
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 1000kg
- Release date
- 2021-09-18