OLEYLHYDROXAMIC ACID
- Product Name
- OLEYLHYDROXAMIC ACID
- CAS No.
- 10335-69-0
- Chemical Name
- OLEYLHYDROXAMIC ACID
- Synonyms
- Einecs 233-728-4;N-hydroxyoleamide;N-Hydroxyoleylamide;N-Hydroxyoleic amide;OLEYLHYDROXAMIC ACID;Oleoylhydroxamic acid;N-Hydroxy-9-octadecenamide;(Z)-N-Hydroxy-9-octadecenamide;(9Z)-9-Octadecenehydroxamic acid;9-Octadecenamide, N-hydroxy-, (9Z)-
- CBNumber
- CB9421385
- Molecular Formula
- C18H35NO2
- Formula Weight
- 297.48
- MOL File
- 10335-69-0.mol
OLEYLHYDROXAMIC ACID Property
- Melting point:
- 61 °C
- Density
- 0.921±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≤50mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 9.48±0.20(Predicted)
- EPA Substance Registry System
- N-Hydroxyoleylamide (10335-69-0)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 19644
- Product name
- MMP-2 Inhibitor I
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $65
- Updated
- 2024/03/01
- Product number
- 19644
- Product name
- MMP-2 Inhibitor I
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $96
- Updated
- 2024/03/01
- Product number
- C5615
- Product name
- MMP-2InhibitorI
- Packaging
- 10mg
- Price
- $108
- Updated
- 2021/12/16
- Product number
- C5615
- Product name
- MMP-2InhibitorI
- Packaging
- 5mg
- Price
- $71
- Updated
- 2021/12/16
OLEYLHYDROXAMIC ACID Chemical Properties,Usage,Production
Biological Activity
mmp-2 inhibitor i, a hydroxamate-based, long-chain fatty acid, is a reversible inhibitor of matrix metalloproteinase (mmp)-2.matrix metalloproteinases (mmps) have been involved in the degradation of extracellular matrix. mmps contribute to long-term remodeling processes such as embryogenesis, tumor invasion, inflammation, angiogenesis, and wound healing. mmp-2, also known as gelatinase a or type iv collagenase, has been involved in regulating diverse cellular functions independent of its action on the extracellular matrix, including vascular tone, platelet aggregation, and mediation of the acute mechanical dysfunction of the heart immediately after ischemia and reperfusion [2]. up-regulation of mmp-2 has been associated with tumor invasion and metastasis [3].mmp-2 inhibitor i inhibited the activity of matrix metalloproteinase (mmp)-2 with the ki value of 1.6 μm [1]. mmp-2 inhibitor i attenuated cancer cell migration [3]. mmp-2 inhibitor i had also been used to preserve blood-brain barrier function in a wistar rat model of pneumococcal meningitis [4].
References
[1] berton a, rigot v, huet e, et al. involvement of fibronectin type ii repeats in the efficient inhibition of gelatinases a and b by long-chain unsaturated fatty acids[j]. journal of biological chemistry, 2001, 276(23): 20458-20465.
[2] wang w, schulze c j, suarez-pinzon w l, et al. intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury[j]. circulation, 2002, 106(12): 1543-1549.
[3] emmert-buck m r, roth m j, zhuang z, et al. increased gelatinase a (mmp-2) and cathepsin b activity in invasive tumor regions of human colon cancer samples[j]. the american journal of pathology, 1994, 145(6): 1285.
[4] barichello t, generoso j s, michelon c m, et al. inhibition of matrix metalloproteinases-2 and-9 prevents cognitive impairment induced by pneumococcal meningitis in wistar rats[j]. experimental biology and medicine, 2014, 239(2): 225-231.
OLEYLHYDROXAMIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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