Nonionic surfactant Erucamide Slippery agent Uses
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Oleamide

Nonionic surfactant Erucamide Slippery agent Uses
Product Name
Oleamide
CAS No.
301-02-0
Chemical Name
Oleamide
Synonyms
ODA;9-OCTADECENAMIDE;(Z)-9-Octadecenamide;Oleic acid amide;9-Octadecenamide,(Z)-;Armid O;Oleamide(ODA);Aliphatic amide;CIS-9-OCTADECENAMIDE;(9Z)-9-Octadecenamide
CBNumber
CB3238286
Molecular Formula
C18H35NO
Formula Weight
281.48
MOL File
301-02-0.mol
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Oleamide Property

Melting point:
70°C
Boiling point:
433.3±24.0 °C(Predicted)
Density 
0.94 g/cm3
storage temp. 
-20°C
solubility 
Soluble in chloroform (50 mg/ml), ethanol (100 mM), DMSO (~14 mg/ml), and DMF (~14 mg/ml)
pka
16.61±0.40(Predicted)
form 
Solid
color 
White to off-white
Water Solubility 
Insoluble in water.
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey
FATBGEAMYMYZAF-KTKRTIGZSA-N
LogP
6.882 (est)
CAS DataBase Reference
301-02-0(CAS DataBase Reference)
NIST Chemistry Reference
9-Octadecenamide, (z)-(301-02-0)
EPA Substance Registry System
Oleamide (301-02-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-43
Safety Statements 
26-36-37
WGK Germany 
1
HS Code 
29241990
Hazardous Substances Data
301-02-0(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1545034
Product name
Plastic additive 12
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
100mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
08393
Product name
Oleamide
Purity
analytical standard
Packaging
25mg
Price
$71.6
Updated
2024/03/01
TCI Chemical
Product number
O0107
Product name
Oleamide
Purity
>65.0%(GC)
Packaging
25g
Price
$35
Updated
2024/03/01
TCI Chemical
Product number
O0107
Product name
Oleamide
Purity
>65.0%(GC)
Packaging
500g
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
90375
Product name
Oleamide
Purity
≥98%
Packaging
50mg
Price
$61
Updated
2024/03/01
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Oleamide Chemical Properties,Usage,Production

Nonionic surfactant

Oleamide is a non-ionic surfactant and is white powder-like or flake-like at room temperature. It is nontoxic, insoluble in water and soluble in hot ethanol, ether other organic solvents. It is obtained by refinement of vegetable oil. It has special internal and external lubrication effect and is relative stable to heat, oxygen, and ultraviolet. It has various kinds of properties including anti-adhesive, slipping, leveling, waterproof, moisture-proof, anti-settling, anti-fouling, anti-static electricity and dispersion. Its effects of anti-sticking, anti-static and dispersion are very strong with no hydroscopic property. It is mainly used for high-pressure polyethylene (LDPE) film and composite film, multi-layer co-extruded film, gas-bag, super-thin film, and the slipping agent, anti-block and anti-static agent for polyvinyl chloride (PVC) calendaring film, polypropylene (PP) and curtain-coating polypropylene (CPP); it can also be used as the slipping agent and release agent of resins such as ethylene-vinyl acetate copolymer (EVA), poly-formaldehyde (POM), polycarbonate (PC), polyethylene terephthalate (PET) and polyamide (PA); it can also be used as the slipping agent and antistatic agent of PU surface treatment agent and fiber masterbatch; caking inhibiter, flatting agent, slipping brightening agent of plastic table printing (compound) inks and thermoplastic PE powder; the lubricant and dispersant of pigments, colorants and masterbatch; a indispensable excellent aids for functional opening, slipping masterbatch: it can also be used as metal protecting agent and the lubricants of polyolefin material.

Erucamide

Erucamide is a higher fatty acid amide and is an important derivative of erucic acid and is refined from vegetable oils. It is as waxy solid with no smell and is insoluble in water. It has certain solubility in organic solvents such as ketones, esters, alcohols, ether and benzene. Since the molecular structure contains long chain and unsaturated C22 chain polar amide group, it has excellent surface polarity effect with high melting point and good thermal stability. It can be as substitutes of other similar additive for being widely applied to other plastic, rubber, printing, machinery and other industries. As the processing aid for polyethylene and polypropylene plastics, it can not only make the products be not bonded and increase lubricity, but also can reinforce the thermoplastic and heat resistance of plastics and the product is also non-toxic. Foreign country has allowed it for being applied to foreign food packaging materials. Add the erucic acid amide into the rubber can increase the gloss of the rubber products, tensile strength and elongation rate and enhance the vulcanization accelerator and abrasion resistance with particularly efficacy in preventing the effect of the sun cracks. Adding it to the ink can increase the adhesion, scratch resistance, offset resistance and dye solubility. In addition, erucic acid amide can also be used as the surface lacquer of the calendared paper, protective films of metal and the foam stabilizer of detergent.
The above information is edited by the chemicalbook of Dai Xiongfeng.

Slippery agent

At present time, common domestic varieties include amides (oleamide and erucamide), soaps (calcium stearate) and organic silicon (silicone). Organic silicon is liquid-like and is expensive as well as being inconvenient for adding usage. There is no domestic professional manufacturer and is difficult for application. Soap products, although is cheap, but has an unsatisfactory effect. It also demands a large adding amount and generally can’t be used in moderate-grade or high-grade products. The slippery agent, oleamide and erucamide has many advantages such as affordable price and significant effect, extremely small addition amount (0.05% to 0.3%), no toxicity (certified by the FDA), wide application range and broad application prospect.
Addition of 0.05%~0.3% oleamide to the low-density polyethylene film can not only improve the antistatic property and lubricating properties, but also improve the anti-moisture performance and can significantly reduce the coefficient of friction and adhesion resistance, significantly increase the efficacy of the membrane blowing (extrusion molding) and can effectively prevent the caking between the film and the agglomeration between the pellets. It may also increase the smoothness of the film surface and prevent the dust accumulation in the surface of the product, leading to very smooth plastic products.
In the polyolefin cable material and wholly plastic communication cable material, addition of oleamide (0.05%) can reduce the friction factor from 0.7 to 0.16 while changing its coloring as well as carbon black dispersion and achieve high-speed extrusion of cable aggregate material and improve the smoothness of the inner wall in the cable jacket pipe.
Adding 2-5 oleamide to the polyamide plastic ink can improve the printing performance and lubricity of ink, enhance the water resistance and scratch resistance and anti-offset characteristic (the fouling caused due to that the ink hasn’t become dry yet) and abrasion resistance. In addition, it can also improve the malleability and adhesiveness of the ink on the printed surface, so that the imprinting is clear and has bright color.

Uses

The purpose is as following:
1, it is the chemical additives which must been added to the low-density polyethylene (LDPE) film material.
2, it is also the modifying agent of the plastic ink.
3, it can also be used as the lubricants such as polypropylene (PP), polystyrene (GPPS), phenol (PF) resin, antistatic agents and anti-caking additives.
4, it can also be used as polyethylene, polypropylene, synthetic fibers and other color concentrates and cables (insulation) material lubricant and release agent.
5, it can also be used as the additive for polypropylene (seal) tabletting, efficient heat sheet and sealed material.
6, metal protective agent; stabilizer of the melamine tableware products; lubricants, antifreeze additives of the brake; lubricants of the coatings and dispersion stabilizer of the aluminum coating as well as oil drilling auxiliaries.

Description

OOleamide (301-02-0) was originally identified in the cerebrospinal fluid of sleep-deprived cats acting as an inducer of physiological sleep in animals.1 Displays agonist activity at cannabinoid CB1 receptors (Ki=8.13 μM).2 Activates PPARγ.3 Produces vasodilator effects in rats.4 Displays neuroprotective effects5 and attenuates sepsis-induced intestinal injury6.

Chemical Properties

White Powder

Uses

A brain lipid that induces physiological sleep at nanomolar quantities when injected into rats. This lipid may represent a new class of biological signaling molecules.

Uses

Oleamide has been used as a supplement in glucose and galactose media to prevent the rescue of galactose-induced Leigh syndrome (LS).

Definition

ChEBI: A fatty amide derived from oleic acid.

General Description

Oleamide?is a lipid or a brain fatty acid, that is found in the CSF (cerebrospinal fluid). It is originally obtained from the cerebrospinal fluid of cats, that are sleep-deprived.

Biological Activity

Endogenous sleep-inducing lipid. Acts as an agonist at the CB 1 cannabinoid receptor (EC 50 = 1.64 μ M). Also appears to potentiate the actions of 5-HT on 5-HT 2A and 2C receptors, and act via an allosteric regulatory site on 5-HT 7 receptors.

Biochem/physiol Actions

Sleep-inducing brain lipid, which allosterically modulates GABAA receptors and potentiates 5-HT7 serotonin receptor responses. Selective endogenous agonist of rat and human CB1 cannabinoid receptor.

Synthesis

Oleamide can be synthesized by ammonolysis of fatty acid or esters with ammonia gas at high pressure.

storage

Store at +4°C

References

Boger et al. (1998), Oleamide: an endogenous sleep-inducing lipid and prototypical member of a new class of biological signaling molecules; Curr. Pharm. Des., 4 303 Leggett et al. (2004), Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors; Br. J. Pharmacol., 141 253 Dionisi et al. (2012), Oleamide activates peroxisome proliferator-activated receptor gamma (PPARγ) in vitro; Lipids Health Dis., 11 51 Hernandez-Diaz et al. (2020), Effects of Oleamide on the Vasomotor Responses in the Rat; Cannabis Cannabinoid Res. 5 42 Maya-Lopez et al. (2020), A Cannabinoid Receptor-Mediated Mechanism Participates in the Neuroprotective Effects of Oleamide Against Excitotoxic Damage in Rat Brain Synaptosomes and Cortical Slices; Neurotox. Res., 37 126 Zou et al. (2019), Cx43 Inhibition Attenuates Sepsis-Induced Intestinal Injury via Downregulating ROS Transfer and the Activation of the JNK1/Sirt1/FoxO3a Signaling Pathway; Mediators Inflamm., 2019 7854389

Oleamide Preparation Products And Raw materials

Raw materials

Preparation Products

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Oleamide Suppliers

Jiangxi Zhilian New Materials Co., Ltd.
Tel
13507965277
Email
jxzlhg163@163.com
Country
China
ProdList
9
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58
Hunan Changsha Hengchang Chemical Co., Ltd.
Tel
0731-85070388 13217318550
Fax
0731-85206809
Email
403640359@qq.com
Country
China
ProdList
22
Advantage
62
hebei crovell biotech Co,.LTD
Tel
19930503252
Email
mia@crovellbio.com
Country
China
ProdList
1458
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9809
Advantage
59
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
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View Lastest Price from Oleamide manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Oleamide 301-02-0
Price
US $1000.00-800.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-16
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Oleamide 301-02-0
Price
US $50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-04-26
Hebei Longbang Technology Co., Ltd
Product
Oleamide 301-02-0
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20TONS
Release date
2024-05-08

301-02-0, OleamideRelated Search:


  • SLEEPAMIDE
  • ODA
  • OLEYRAMIDE
  • OLEYLAMIDE
  • OLEAMIDE
  • 9-Octadecenamide,(Z)-
  • 9-octadecenoicacid,amide(cis)
  • oleicacidamide
  • Petrac Slip-Eze
  • Polydis TR 121
  • Slip-eze
  • Unislip 1759
  • AKAWAX O-BEADS
  • AKAWAX O-MICROBEADS
  • 9Z-OCTADECENAMIDE
  • 9-OCTADECENAMIDE
  • 9,10-OCTADECENOAMIDE
  • CIS-9-OCTADECENAMIDE
  • CIS-9-OCTADECENOAMIDE
  • CIS-9,10-OCTADECANAMIDE
  • CIS-9,10-OCTADECENAMIDE
  • CIS-9,10-OCTADECENOAMIDE
  • (9Z)-9-Octadecenamide
  • (Z)-9-Octadecenamide
  • OLEAMIDE (CIS-9,10-OCTADECENOAMIDE, OLEI
  • cis-9,10-Octadecenoamide, Oleylamide
  • 9-Octadecenamide, (9Z)-
  • OLEAMID
  • OLEINAMIDE
  • Adogen 73
  • adogen73
  • Aliphatic amide
  • Amide O
  • Armid O
  • Armoslip CP
  • armoslipcp
  • Crodamide O
  • Crodamide O, OR
  • Crodamide OR
  • crodamideo
  • crodamideor
  • Diamide O 200
  • Diamit O 200
  • Kemamide O
  • Octadecene amide
  • Oleic acid amide
  • cis-9,10-Octadecenoamide, cis-9-Octadecenamide, Oleic acid amide
  • Theoleic aMide
  • Oleamide R
  • oleic amide
  • (Z)-Octadec-9-enamide
  • Unislip 4407
  • Nsc26987
  • AMD-O
  • KeMaMide U
  • Neutron (aMide)
  • cis-9-Octadecenamide Oleyramide
  • CHaMide P