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SPLITOMICIN

Product Name
SPLITOMICIN
CAS No.
5690-03-9
Chemical Name
SPLITOMICIN
Synonyms
Spitomicin;Splitomycin;SPLITOMICIN;Splitomicin >1H-Benzo[f]chromen-3(2H)-one;1,2-Dihydro-3H-benzo[f]chromen-3-one;1,2-DIHYDRO-3H-NAPHTHO[2,1-B]PYRAN-3-ONE;2-Hydroxy-1-naphthalenepropanoic acid delta-lactone;Inhibitor,Histone deacetylases,Splitomycin,HDAC,inhibit,Splitomicin
CBNumber
CB5227437
Molecular Formula
C13H10O2
Formula Weight
198.22
MOL File
5690-03-9.mol
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SPLITOMICIN Property

Melting point:
73-74.5℃
storage temp. 
2-8°C
solubility 
insoluble in H2O; ≥44.2 mg/mL in EtOH with ultrasonic; ≥9.05 mg/mL in DMSO
form 
solid
color 
White to Almost white
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Safety

WGK Germany 
3
HS Code 
2932.20.4500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S4068
Product name
Splitomicin
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$55.62
Updated
2024/03/01
Sigma-Aldrich
Product number
567750
Product name
Splitomicin - CAS 5690-03-9 - Calbiochem
Purity
A cell-permeable lactone derived from β-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC?? = 60 μM).
Packaging
5MG
Price
$201
Updated
2024/03/01
TCI Chemical
Product number
S0892
Product name
Splitomicin
Purity
>98.0%(GC)
Packaging
1g
Price
$424
Updated
2024/03/01
TCI Chemical
Product number
S0892
Product name
Splitomicin
Purity
>98.0%(GC)
Packaging
200mg
Price
$142
Updated
2024/03/01
Cayman Chemical
Product number
13168
Product name
Splitomicin
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
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SPLITOMICIN Chemical Properties,Usage,Production

Uses

Splitomicin is a selective and potent inhibitor of Sir2 (silent information regulator 2), producing an inhibitory effect on neutrophils. Acts as an anti-inflammatory agent.

Definition

ChEBI: A benzochromenone that is 2,3-dihydro-1H-benzo[f]chromene substituted by an oxo group at position 3. It has been found to exhibit potential inhibitory activity against Sir2 proteins.

Synthesis Reference(s)

Journal of the American Chemical Society, 69, p. 2341, 1947 DOI: 10.1021/ja01202a027

General Description

A cell-permeable and selective inhibitor of NAD+-dependent deacetylase activity of Sir2 protein (IC50 = 60 μM). Creates a phenocopy of the sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Reported to act by either altering or blocking access to the acetylated histone-binding pocket.

Biological Activity

Inhibitor of Sir2p (IC 50 = 60 μ M), an NAD + -dependent Sir2 family deacetylase required for chromatin-dependent silencing in yeast.

Biochem/physiol Actions

Cell permeable: yes

storage

+4°C

SPLITOMICIN Preparation Products And Raw materials

Raw materials

Preparation Products

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SPLITOMICIN Suppliers

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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China
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
Fax
86-21-50328109
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3bsc@sina.com
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China
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TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
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China
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TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
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9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
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China
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Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
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China
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Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
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1400878000@qq.com
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China
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9958
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Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
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China
ProdList
4512
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
Email
info@efebio.com
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China
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9806
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58

5690-03-9, SPLITOMICINRelated Search:


  • SPLITOMICIN
  • 1H-Benzo[f]chromen-3(2H)-one
  • 1,2-DIHYDRO-3H-NAPHTHO[2,1-B]PYRAN-3-ONE
  • 2-Hydroxy-1-naphthalenepropanoic acid delta-lactone
  • Splitomycin
  • Splitomicin &gt
  • Spitomicin
  • 1,2-Dihydro-3H-benzo[f]chromen-3-one
  • Inhibitor,Histone deacetylases,Splitomycin,HDAC,inhibit,Splitomicin
  • 5690-03-9
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Gene Regulation and Expression
  • DNA-RNA Transcription Regulators
  • Inhibitors