SPLITOMICIN
- Product Name
- SPLITOMICIN
- CAS No.
- 5690-03-9
- Chemical Name
- SPLITOMICIN
- Synonyms
- Spitomicin;Splitomycin;SPLITOMICIN;Splitomicin >1H-Benzo[f]chromen-3(2H)-one;1,2-Dihydro-3H-benzo[f]chromen-3-one;1,2-DIHYDRO-3H-NAPHTHO[2,1-B]PYRAN-3-ONE;2-Hydroxy-1-naphthalenepropanoic acid delta-lactone;Inhibitor,Histone deacetylases,Splitomycin,HDAC,inhibit,Splitomicin
- CBNumber
- CB5227437
- Molecular Formula
- C13H10O2
- Formula Weight
- 198.22
- MOL File
- 5690-03-9.mol
SPLITOMICIN Property
- Melting point:
- 73-74.5℃
- storage temp.
- 2-8°C
- solubility
- insoluble in H2O; ≥44.2 mg/mL in EtOH with ultrasonic; ≥9.05 mg/mL in DMSO
- form
- solid
- color
- White to Almost white
Safety
- WGK Germany
- 3
- HS Code
- 2932.20.4500
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- S4068
- Product name
- Splitomicin
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $55.62
- Updated
- 2024/03/01
- Product number
- 567750
- Product name
- Splitomicin - CAS 5690-03-9 - Calbiochem
- Purity
- A cell-permeable lactone derived from β-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC?? = 60 μM).
- Packaging
- 5MG
- Price
- $201
- Updated
- 2024/03/01
- Product number
- S0892
- Product name
- Splitomicin
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $424
- Updated
- 2024/03/01
- Product number
- S0892
- Product name
- Splitomicin
- Purity
- >98.0%(GC)
- Packaging
- 200mg
- Price
- $142
- Updated
- 2024/03/01
- Product number
- 13168
- Product name
- Splitomicin
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
SPLITOMICIN Chemical Properties,Usage,Production
Uses
Splitomicin is a selective and potent inhibitor of Sir2 (silent information regulator 2), producing an inhibitory effect on neutrophils. Acts as an anti-inflammatory agent.
Definition
ChEBI: A benzochromenone that is 2,3-dihydro-1H-benzo[f]chromene substituted by an oxo group at position 3. It has been found to exhibit potential inhibitory activity against Sir2 proteins.
Synthesis Reference(s)
Journal of the American Chemical Society, 69, p. 2341, 1947 DOI: 10.1021/ja01202a027
General Description
A cell-permeable and selective inhibitor of NAD+-dependent deacetylase activity of Sir2 protein (IC50 = 60 μM). Creates a phenocopy of the sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Reported to act by either altering or blocking access to the acetylated histone-binding pocket.
Biological Activity
Inhibitor of Sir2p (IC 50 = 60 μ M), an NAD + -dependent Sir2 family deacetylase required for chromatin-dependent silencing in yeast.
Biochem/physiol Actions
Cell permeable: yes
storage
+4°C
SPLITOMICIN Preparation Products And Raw materials
Raw materials
Preparation Products
SPLITOMICIN Suppliers
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